Protein Alignment CG3529 and GGA1

DIOPT Version :10

• Sequence 1: NP_648315.1
• Gene: CG3529 / 39093
• FlyBaseID: FBgn0035995
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 129/564 - (22%)
• Similarity: 221/564 - (39%)
• Gaps: 103/564 - (18%)

  Fly    21 RIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL------- 78
            ||..||:......:||:....|:.:||..:....|.|.:..:: |:..:...:...|:
Human    13 RINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKI-QSPQEWEAIQALTVRRGEATI 76

  Fly    79 --------TVLETCVKNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWAD 132
                    .|||||:|:|||.||..|.:..|:|||:|::.||   :.....::.|:|.|:..|..
Human    77 RPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTV 141

  Fly   133 AFKNQPDLNGVTQMYMELKNKGI--EFPANDLDAMAPIYTPQ-RSV---PEMPPQLVAAQQHTIS 191
            ..   |:...:.:.|..||.:||  ..|....|...|:..|: ::|   .|...:::|....:..
Human   142 GL---PEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSH 203

  Fly   192 PQHMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEM-LSVLKPGQESPDDY 255
            |:.:.||.............     ..|:.:|..:.:|.|:||:.:|:|| :|..:.|..:....
Human   204 PEDLRAANKLIKEMVQEDQK-----RMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSE 263

  Fly   256 ALLNELTSTCKEMQSRIVDLIGRVQD-DELTAEFLRINDELNNV------FLRHQRYEKNRSQGQ 313
            .|:.||...|:.|:..:..|....:| ||..||.|:.||.|..|      .:|.:....:.:.|.
Human   264 DLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGS 328

  Fly   314 GAGVTSPSAVLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLP 378
            ..|.||      |.:.|.|:....|| ||...:|..|...|....|.:...|:|
Human   329 IPGSTS------ALLDLSGLDLPPAG-TTYPAMPTRPGEQASPEQPSASVSLLD----------- 375

  Fly   379 QSLGQISLGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKP 443
            ..|..:.|....|        |:.                      ||:|....:...::...:|
Human   376 DELMSLGLSDPTP--------PSG----------------------PSLDGTGWNSFQSSDATEP 410

  Fly   444 NQPQQAQRSAGE--PPVVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDKFLEERAAAAENLP 506
            ..|..||..:.|  ||..:.....:.:|:::. ||.:.   :::....|..:...|:......|.
Human   411 PAPALAQAPSMESRPPAQTSLPASSGLDDLDL-LGKTL---LQQSLPPESQQVRWEKQQPTPRLT 471

  Fly   507 TISASNSAASATTGSAGADSLRKT--------PKKPGAEEDLLA 542
            .....|.::|.::.|:.|.||..|        |::|...|..||
Human   472 LRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLA 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1_like	17..154	CDD:340768	40/150 (27%)
		GAT_TOM1_like	222..307	CDD:410581	27/92 (29%)
GGA1	NP_001350700.1	VHS_GGA1	9..164	CDD:340806	42/154 (27%)
		GGA_N-GAT	186..224	CDD:465702	5/42 (12%)
		GAT_GGA1_GGA2	227..315	CDD:410586	26/87 (30%)
		Alpha_adaptinC2	534..648	CDD:197886