Protein Alignment Rdl and GLRA3

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 180/575 - (31%)
• Similarity: 272/575 - (47%)
• Gaps: 152/575 - (26%)

  Fly    26 AINMALIA-QETGHKRIHTVQAATGGGSMLGDVNISAILDSF---SVSYDKRVRPNYGGPPVEVG 86
            |:.::|:| :||...|           |....::.|..||..   :..||.|:|||:.||||.|.
Human    20 ALLLSLVATKETDSAR-----------SRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVT 73

  Fly    87 VTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEK 151
            ..:::.|..|::|..||:.::.:.||.|.||||||.:.|. ::|.:....:.:||.||.||.|||
Human    74 CNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPD-DSLDLDPSMLDSIWKPDLFFANEK 137

  Fly   152 QSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYF 216
            .:.||..||.|:.:|:..:|::..|||||:|.||||:|:.||||.|.|.:::|||||||.|:.:.
Human   138 GANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFE 202

  Fly   217 WRDGLSSVGMSSEVELPQFRVLGHRQ-RATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGL 280
            |:|. :.|.::..:.||||.:...:. |....:..||.::.:.......|.|||||||:||||.|
Human   203 WQDE-APVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLL 266

  Fly   281 IVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASL 345
            |||:||||||:|.:|.|||||||:||||||||..|.:.|:|||:||||:||:::..|.:.||::|
Human   267 IVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSAL 331

  Fly   346 LEYATVGYMAKR----IQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPG 406
            ||||.|.:::::    ::.|::|....:..|.:|..:
Human   332 LEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYR---------------------------- 368

  Fly   407 GPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVG 471
                                                            ||::...|
Human   369 ------------------------------------------------FSDMDDEV--------- 376

  Fly   472 PLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGD 536
               :|.||..   .|:..|..|:                              ...|..|:|...
Human   377 ---RESRFSF---TAYGMGPCLQ------------------------------AKDGMTPKGPNH 405

  Fly   537 PEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIY 591
            |...:|         |...::.|:.......||..||..||:.|:.||:.||:||
Human   406 PVQVMP---------KSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	69/183 (38%)
		Cys-loop	185..199	CDD:349809	9/13 (69%)
		Neur_chan_memb	274..588	CDD:460753	80/317 (25%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	178/573 (31%)