DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rdl and GABRQ

DIOPT Version :10

Sequence 1:NP_001261617.1 Gene:Rdl / 39054 FlyBaseID:FBgn0004244 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_061028.3 Gene:GABRQ / 55879 HGNCID:14454 Length:632 Species:Homo sapiens


Alignment Length:615 Identity:184/615 - (29%)
Similarity:283/615 - (46%) Gaps:121/615 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 ISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRK 123
            :..|||.....||.|:|||:||.||.|.:::||.||..:||:.||:|:..:|.|.|.|.||||  
Human    59 VQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAY-- 121

  Fly   124 RPGVET---LSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
               .||   |::.....:.:||||.:|:|.|.::.|..|..|...::|..|::...||||.||:|
Human   122 ---YETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAAC 183

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLT 250
            .::|..||||:|.|::.:||:|||:.||..||.|..:::.|:.|:.:|||..||....:.|:...
Human   184 SLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFY 248

  Fly   251 TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMS 315
            ||:|.||..:.|..|.:..||:|:|.|:.|..|.||:|||:|.:::.|||.:|:|::|.:||:.|
Human   249 TGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDS 313

  Fly   316 STNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYM----AKRIQMRKQRFMAIQKIAEQKK 376
            .....||.||.:|:||:|:..|...||.|||||..:.|:    ..|.|.|:.| ...:.||..:.
Human   314 HLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHR-RPRRVIARYRY 377

  Fly   377 QQL-------------DGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHG 428
            ||:             ||.:.....| ..|.:..|..:    |..........:.....:.|   
Human   378 QQVVVGNVQDGLINVEDGVSSLPITP-AQAPLASPESL----GSLTSTSEQAQLATSESLSP--- 434

  Fly   429 HGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTR------GCSIVGPLFQEVRFKVHDPKAH 487
                ..:.|...|.|..:::|:.|......:.:.|.|      ..||:.   .|:|.:|   :||
Human   435 ----LTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIP---TEIRNRV---EAH 489

  Fly   488 SKGGTLEN-TVNGGRGGPQSHGPGPGQGGGPP----GGGGGGGGG-------------------- 527
            ..|.|.:: ..|......:.||.||   .|.|    |..|....|                    
Human   490 GHGVTHDHEDSNESLSSDERHGHGP---SGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFK 551

  Fly   528 -----------------GGPPEGGGDPEAAVPA------------HLLHPGKVKKVKDINKLLGI 563
                             |...:...:.|.:.|.            .|.:|..|.||         
Human   552 CDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKV--------- 607

  Fly   564 TPSDIDKYSRIVFPVCFVCFNLMYWIIYLH 593
                 ||:||.:||:.|..||::||:.:::
Human   608 -----DKWSRFLFPLAFGLFNIVYWVYHMY 632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RdlNP_001261617.1 LGIC_ECD_GABAR_RDL-like 83..266 CDD:349809 72/185 (39%)
Cys-loop 185..199 CDD:349809 7/13 (54%)
Neur_chan_memb 274..588 CDD:460753 94/390 (24%)
GABRQNP_061028.3 LGIC_ECD_GABAAR_theta 82..264 CDD:349804 73/186 (39%)
Cys-loop 183..197 CDD:349804 7/13 (54%)
LGIC_TM_GABAAR_theta 267..>355 CDD:349858 39/87 (45%)
TM1 helix 267..290 CDD:349858 12/22 (55%)
TM2 helix 294..318 CDD:349858 9/23 (39%)
TM3 helix 326..352 CDD:349858 12/25 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 410..458 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..523 9/34 (26%)
LGIC_TM <598..630 CDD:476813 16/45 (36%)
TM4 helix 606..627 CDD:349850 11/34 (32%)

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