Protein Alignment Rdl and Gabra1

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_899155.1
• Gene: Gabra1 / 29705
• RGDID: 61855
• Length: 455
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 157/539 - (29%)
• Similarity: 227/539 - (42%)
• Gaps: 146/539 - (27%)

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            |||.....||.|:||..|....||...::|.|...:|:..|::|:|.:|||.|.|.||.: |.|
  Rat    44 ILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKF-KGP- 106

  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191
            :..|.:.:.....||.|||||.|.|:|..|..|..|:.:|:...|::..::|||:.|.|||:|:.
  Rat   107 MTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLED 171

  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFW-RDGLSSVGMSSE-VELPQFRVLGHRQRATEINLTTGNY 254
            ||||...|.::..|:.||..::.|.| |:...||.::.: ..|.|:.:||....:..:..:||.|
  Rat   172 FPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEY 236

  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319
            ..:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...
  Rat   237 VVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 301

  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQ 384
            :|||::|..::|.::..|:..||::|:|:|||.|..||
  Rat   302 SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR--------------------------- 339

  Fly   385 QQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVS 449
                                                                  |:....|..|.
  Rat   340 ------------------------------------------------------GYAWDGKSVVP 350

  Fly   450 NRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQG 514
            .:|                          .||.||.. .|..|...|..       |:.|...:
  Rat   351 EKP--------------------------KKVKDPLI-KKNNTYAPTAT-------SYTPNLAR- 380

  Fly   515 GGPPGGGGGGGGGGGPPEGGGDPEAAVPAH--LLHPGKVK---KVKDINKLLGITPSDIDKYSRI 574
                                |||..|..|.  .:.|.:||   |..:..|... :.|.||:.|||
  Rat   381 --------------------GDPGLATIAKSATIEPKEVKPETKPPEPKKTFN-SVSKIDRLSRI 424

  Fly   575 VFPVCFVCFNLMYWIIYLH 593
            .||:.|..|||:||..||:
  Rat   425 AFPLLFGIFNLVYWATYLN 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	61/184 (33%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	78/318 (25%)
Gabra1	NP_899155.1	LIC	7..441	CDD:455710	155/535 (29%)
		LGIC_ECD_GABAAR_A1	55..248	CDD:349835	65/194 (34%)
		Cys-loop	165..179	CDD:349835	8/13 (62%)