Protein Alignment Rdl and Gabrd

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_058985.1
• Gene: Gabrd / 29689
• RGDID: 61901
• Length: 449
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 174/580 - (30%)
• Similarity: 256/580 - (44%)
• Gaps: 150/580 - (25%)

  Fly    24 WLAINMALIAQETGHKRIHTVQAATGGGSMLG-DVNISAI--LDSFSVSYDKRVRPNYGGPPVEV 85
            ||.:.:.|:..:. |   |..:|....|..:| ::.||.:  ||.....|.:..||..|||||.|
  Rat     6 WLLLPLLLLCTQP-H---HGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNV 66

  Fly    86 GVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNE 150
            .:.:.|.||..:||..|::|:..:..|.|.|.||:|....  |||.:.|.|:..:|:||||.||.
  Rat    67 ALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTN--ETLGLDSRFVDKLWLPDTFIVNA 129

  Fly   151 KQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRY 215
            |.::||..|..|:.||:...|.|..|||:|.|.:|.|:|..:|||.|.|.:::||:||:..||.|
  Rat   130 KSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVY 194

  Fly   216 FWRDGLSSVGMSSEVELPQFRVLGHRQRATEINL-TTGNYSRLACEIQFVRSMGYYLIQIYIPSG 279
            :|.:....:.....::|.||.:..:|.....:|. :.|.:.||:...|..|:.|.|:||.|:||.
  Rat   195 YWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSV 259

  Fly   280 LIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFAS 344
            |:|.:||||||:::.|.||||:||:||||||||||.|..::||:.|.:|::|||...|:|.|||:
  Rat   260 LLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAA 324

  Fly   345 LLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQ--------QLDGANQQQANPNPNANVGGPGGV 401
            |:|||...:.|...:.||.:....:..||...:        ...|.:|:.|.......|  ||.:
  Rat   325 LVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRV--PGNL 387

  Fly   402 GVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRG 466
                                 ||                        |.|.:
  Rat   388 ---------------------MG------------------------SYRSV------------- 394

  Fly   467 CSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPP 531
                     ||..|                               .:||..|||
  Rat   395 ---------EVEAK-------------------------------KEGGSRPGG----------- 408

  Fly   532 EGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIY 591
                            ||.::     ::|..|....||.|:|.|||..|...|::||..|
  Rat   409 ----------------PGGIR-----SRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAY 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	66/183 (36%)
		Cys-loop	185..199	CDD:349809	7/13 (54%)
		Neur_chan_memb	274..588	CDD:460753	81/321 (25%)
Gabrd	NP_058985.1	LGIC_ECD	63..246	CDD:475126	67/184 (36%)
		LGIC_TM	249..>337	CDD:476813	49/87 (56%)
		TM1 helix	252..272	CDD:349850	13/19 (68%)
		TM2 helix	281..302	CDD:349850	13/20 (65%)
		TM3 helix	312..334	CDD:349850	11/21 (52%)