Protein Alignment Rdl and Gabra2

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_017454595.1
• Gene: Gabra2 / 289606
• RGDID: 61856
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 170/596 - (28%)
• Similarity: 248/596 - (41%)
• Gaps: 164/596 - (27%)

  Fly    17 RTPLLT--IWLAINMALI----------AQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVS 69
            ||.|.|  :|..:.:.|:          .||...|...|:              .:.|||.....
  Rat    55 RTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITI--------------FTRILDRLLDG 105

  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134
            ||.|:||..|....||...:||.|...:|:..|::|:|.:|||.|.|.||.: |.| :..|.:.:
  Rat   106 YDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKF-KGP-MNILRLNN 168

  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199
            .....||.|||||.|.|:|..|..|..|:.:|:...|::..::|||:.|.|||:|:.||||...|
  Rat   169 LMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC 233

  Fly   200 HIEIESFGYTMRDIRYFWRDGLS-SVGMSSE-VELPQFRVLGHRQRATEINLTTGNYSRLACEIQ 262
            .::..|:.||..::.|.|....| ||.::.: ..|.|:.:||.......|..:||.|:.:.....
  Rat   234 PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFH 298

  Fly   263 FVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYV 327
            ..|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...:|||::|.
  Rat   299 LKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 363

  Fly   328 KSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPN 392
            .::|.::..|:..||::|:|:|||.|..|    |...:.....:.::||::.....|..|.....
  Rat   364 TAMDWFIAVCYAFVFSALIEFATVNYFTK----RGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAV 424

  Fly   393 ANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSN 457
            ||                                               :||  .:|..|: .|.
  Rat   425 AN-----------------------------------------------YAP--NLSKDPV-LST 439

  Fly   458 IQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGG 522
            |.::..|
  Rat   440 ISKSATT---------------------------------------------------------- 446

  Fly   523 GGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMY 587
                    ||....||.       .|.:.||.  .|.:     |.||:.|||||||.|..|||:|
  Rat   447 --------PEPNKKPEN-------KPAEAKKT--FNSV-----SKIDRMSRIVFPVLFGTFNLVY 489

  Fly   588 WIIYLHVSDVV 598
            |..||:...|:
  Rat   490 WATYLNREPVL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	63/184 (34%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	78/313 (25%)
Gabra2	XP_017454595.1	LIC	64..493	CDD:455710	163/578 (28%)
		LGIC_ECD_GABAAR_A2	100..302	CDD:349836	70/203 (34%)
		Cys-loop	219..233	CDD:349836	8/13 (62%)