Protein Alignment Rdl and GABRP

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_055026.1
• Gene: GABRP / 2568
• HGNCID: 4089
• Length: 440
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 142/534 - (26%)
• Similarity: 245/534 - (45%)
• Gaps: 140/534 - (26%)

  Fly    64 DSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVE 128
            ::.:..|:|.:|||:||.||::.:|:.:.||||:||..||:|...|.||.|.|.||.:.   |.:
Human    42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFE---GNK 103

  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193
            :.::.:..::.:|||||:.|..|:|:.|..|..|..||:..:|::..::|:|.|.:|.|:|..:|
Human   104 SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYP 168

  Fly   194 MDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLA 258
            ||.|.|.:::||:||...|:.:.|..|..||.....:.|.|:.:..:....|.....||||:||.
Human   169 MDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLV 233

  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323
            .:.:..|::.|::::.|:||..:|::||||||::.::.|||..:||||||:|||||..:..:||.
Human   234 LQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPN 298

  Fly   324 IS-YVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQA 387
            .: ::|:||||||.||..||.:|||||...|            .::|::|.:     |....::.
Human   299 TNCFIKAIDVYLGICFSFVFGALLEYAVAHY------------SSLQQMAAK-----DRGTTKEV 346

  Fly   388 NPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRP 452
            ......|:                   :|..:                           :...|.
Human   347 EEVSITNI-------------------INSSI---------------------------SSFKRK 365

  Fly   453 IGFSNIQ---QNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQG 514
            |.|::|:   .||.          :.::..|..|
Human   366 ISFASIEISSDNVD----------YSDLTMKTSD------------------------------- 389

  Fly   515 GGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVC 579
                                       ....:...|:.::.|...:.  .||::|.||:::||:.
Human   390 ---------------------------KFKFVFREKMGRIVDYFTIQ--NPSNVDHYSKLLFPLI 425

  Fly   580 FVCFNLMYWIIYLH 593
            |:..|:.||..|::
Human   426 FMLANVFYWAYYMY 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	62/182 (34%)
		Cys-loop	185..199	CDD:349809	7/13 (54%)
		Neur_chan_memb	274..588	CDD:460753	67/317 (21%)
GABRP	NP_055026.1	LIC	43..437	CDD:455710	141/529 (27%)
		LGIC_ECD	60..241	CDD:475126	63/183 (34%)