Protein Alignment Rdl and Gabrb2

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_008765857.1
• Gene: Gabrb2 / 25451
• RGDID: 2650
• Length: 506
• Species: Rattus norvegicus
• Alignment Length: 584
• Identity: 190/584 - (32%)
• Similarity: 286/584 - (48%)
• Gaps: 133/584 - (22%)

  Fly    46 AATGGGSMLGDVNISAI---LDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLD 107
            ||....|:....|:|.:   :|.....||.|:||::|||||.||:.:.:.||..:|||.||:||.
  Rat    20 AAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLT 84

  Fly   108 FYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGS 172
            .||:|.|.|.||:|...|  ..|::.:.....:|||||:|:|:|:|:.|..|..|..||:|..|:
  Rat    85 MYFQQAWRDKRLSYNVIP--LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGT 147

  Fly   173 ITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV 237
            :...:|:|.||:|.|:|:.:|:|.|.|.:||||:|||..||.::||...::|...:::|||||.:
  Rat   148 VLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSI 212

  Fly   238 LGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVAL 302
            :.::....::..:||:|.||:...:..|::||:::|.|:||.||.|:||||||:|.:|:.|||||
  Rat   213 VDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 277

  Fly   303 GVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMA 367
            |:||||||||:.:.....||||.|||:||:||..|||.||.:|||||.|.|:.  .....||
  Rat   278 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIF--FGRGPQR--- 337

  Fly   368 IQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHG 432
                  |||     |.::.||.|..
  Rat   338 ------QKK-----AAEKAANANNE---------------------------------------- 351

  Fly   433 HHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGP----LFQEVRFKVHDPKAHSKGGTL 493
                        |..:....|.:.:|:|| .|:..|:..|    .:......:.||..:....||
  Rat   352 ------------KMRLDVNKIFYKDIKQN-RTQYQSLWDPTRWTTYYHFSLYMMDPHENILLSTL 403

  Fly   494 ENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDP---------------EAAVPA 543
            |  :.......::                        ..|.|||               :|.:|.
  Rat   404 E--IKNEMATSEA------------------------VMGLGDPRSTMLAYDASSIQYRKAGLPR 442

  Fly   544 HLL-------HPGKVK-KVKDINKLLGITPSD------IDKYSRIVFPVCFVCFNLMYWIIYLH 593
            |..       |..:.| :::.....|.||..|      ||::|||.|||.|..||::||:.|::
  Rat   443 HSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	71/182 (39%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	97/346 (28%)
Gabrb2	XP_008765857.1	LIC	9..504	CDD:455710	189/580 (33%)