Protein Alignment Rdl and Gabrr3

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 152/536 - (28%)
• Similarity: 236/536 - (44%)
• Gaps: 151/536 - (28%)

  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134
            :|...||.:||.||.||:.:.|.||.|:|||.||||:.||.|.:|.|.||::..... ::::...
  Rat    67 HDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTN-KSMTFDR 130

  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199
            ..|:.|||||.|||:.|:|:.|..|..|..:|||..|::..|:|:|::|.|.|:...||:|.|.|
  Rat   131 RLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNC 195

  Fly   200 HIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINL----TTGNYSRLACE 260
            .:|:||:.|...|:..:|:.|..|:.....:.|.||.:   .:.:....|    :||.|.||...
  Rat   196 SLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFI---EEFSASSGLAFYSSTGWYYRLFIN 257

  Fly   261 IQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKIS 325
            ....|.:.::::|.|.|:.|:|::||||||::|.|.||||:||:||||||:|:::..:|::|::|
  Rat   258 FVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVS 322

  Fly   326 YVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPN 390
            |||::|||:....:.||.|::|||.|.|:.               ..|:.||    .|::
  Rat   323 YVKAVDVYMWVSSLFVFLSVIEYAAVNYLT---------------TVEEWKQ----LNRR----- 363

  Fly   391 PNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGF 455
                              |...|..|:.....|..:
  Rat   364 ------------------GKISGMYNIDAVQAMAFD----------------------------- 381

  Fly   456 SNIQQNVGTRGCSIVGPLFQEVRFKVHDPKA---------HSKGGTLENTVNGGRGGPQSHGPGP 511
                      ||             .||.:.         ||:..::.....|......|.....
  Rat   382 ----------GC-------------YHDGETDVDQTSFFLHSEEDSMRTKFTGSPCADSSQIKRK 423

  Fly   512 GQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVF 576
            ..||                                        ::.:::......||.||||||
  Rat   424 SLGG----------------------------------------NVGRIILENNHVIDTYSRIVF 448

  Fly   577 PVCFVCFNLMYWIIYL 592
            ||.::.|||.||.||:
  Rat   449 PVVYIIFNLFYWGIYV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	67/186 (36%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	73/322 (23%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:455710	150/533 (28%)
		LGIC_ECD	79..264	CDD:475126	69/188 (37%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		26/234 (11%)