Protein Alignment Rdl and lgc-50

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_498637.3
• Gene: lgc-50 / 188633
• WormBaseID: WBGene00020605
• Length: 491
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 137/566 - (24%)
• Similarity: 236/566 - (41%)
• Gaps: 133/566 - (23%)

  Fly    57 VNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAY 121
            :|:..::|:....||..:.|...|  |.|.:.::|..:|.:||:..||:||..:.:.|.||||::
 Worm    30 INLGKLIDTLLTDYDTHLLPEAEG--VNVTIELHVQGVSGISEITGDFSLDVMYSEIWQDPRLSF 92

  Fly   122 RKRPGVET-LSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
            :......| :::.|:|.|.||.|||..:|.|.|..|.:.:.|.|:.::.:|.:..:.||.:...|
 Worm    93 KHLNVCATNITLKSDFRKKIWTPDTCIINSKSSSIHSSPSENTFVILYENGLVWSNFRLNVKTPC 157

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLT 250
            .:||:.||.|...|.|.:||:.:...::|..|.|  ..:.|..:||||.|.::|.......:...
 Worm   158 SVNLKMFPFDSLSCEIVLESYSFNTDEVRLMWHD--VPITMMEKVELPDFDLIGWSTDHQRLEYP 220

  Fly   251 TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMS 315
            .|.:.|...:..|.|..|:||.|.|.|:.|.||.|||.|:.:..:..||:.|||:::|.:|....
 Worm   221 NGIWDRAKVKFTFARRYGFYLFQSYFPTSLTVISSWVGFFFDVRSVSARITLGVSSLLALTFQFG 285

  Fly   316 STNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMA-------IQKIAE 373
            :....||::||:|.:||::....:.:|.:|:|.|.|..:.:   ..::|.:.       :.:|.:
 Worm   286 NVLRHLPRVSYIKCLDVWMIFSVIFIFCTLVELAIVCQLNR---WERERQIGSKVLGHWLNQIRK 347

  Fly   374 QKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGV------------------NVGVG 420
            .:|::            ..|:.||.|||           ||:                  |.|..
 Worm   348 TRKKE------------SKADEGGGGGV-----------GGLLRKRIPVLAQLKAAATDSNSGAA 389

  Fly   421 MGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPK 485
            ..|                       |.:.:|.. :|:.....:....:|...|..:.   |:..
 Worm   390 TAM-----------------------TTAIQPPN-TNLNSITNSDNSKLVANNFTSIE---HETY 427

  Fly   486 AHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGK 550
            |:.|          .||  .||                                      .....
 Worm   428 AYEK----------KRG--FSH--------------------------------------CFQRF 442

  Fly   551 VKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSD 596
            |..:...::...||...:|:.|.|:||:.|:.||::||.||....|
 Worm   443 VYAICPPDRDWTITSVQVDRCSMIMFPLSFLIFNVVYWSIYFMKMD 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	56/183 (31%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	65/338 (19%)
lgc-50	NP_498637.3	LIC	34..483	CDD:455710	133/555 (24%)
		LGIC_ECD_GABAAR	54..236	CDD:349791	56/183 (31%)
		Cys-loop	157..171	CDD:349791	6/13 (46%)