Protein Alignment Rdl and lgc-54

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001343648.1
• Gene: lgc-54 / 188525
• WormBaseID: WBGene00020528
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 131/535 - (24%)
• Similarity: 227/535 - (42%)
• Gaps: 125/535 - (23%)

  Fly    66 FSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG-VET 129
            |..:|:|...|......| |.|...:.:|:.:||:...||||..|.|.|.||||.:..... ::.
 Worm    60 FDDNYNKNTVPLKTSATV-VSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRFDHLTNCLQN 123

  Fly   130 LSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPM 194
            |::|...::.:|.|:..|||.|::..|.:.|.|.|:.::.:|::..:.||.:.:.|.::|..|||
 Worm   124 LTLGYSMVEKLWTPNVCFVNSKKTEIHSSPTPNIFLMIYPNGTVWVNYRLQVQSPCMVDLVLFPM 188

  Fly   195 DRQLCHIEIESFGYTMRDIRYFWRD--GLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRL 257
            |...|.:.|||:.|....::..||:  .:.|:..|   :|..|.:.|.:..........|.:.:|
 Worm   189 DIMNCELIIESYAYNAAKVKLNWREWQPVFSIAKS---KLSDFTLYGLQWTKNSFEYAAGQWDQL 250

  Fly   258 ACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALP 322
            ...:.|.|:.|:|::|:|||:...|.:|:||||::..|.|||:.|||::::.:|....:....||
 Worm   251 TVSLTFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTFQYGNVAKNLP 315

  Fly   323 KISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQA 387
            ::.||||||||:......:|.:::|.|.|.|:.....:|::     ::.||:||:::  |..|:.
 Worm   316 RVGYVKSIDVYMVLTTAFIFLTMIEVAFVCYLDSENNLRRK-----ERQAEKKKERV--AVLQRK 373

  Fly   388 NPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRP 452
            ......|.|.                                                .||:|..
 Worm   374 KDRKKNNYGA------------------------------------------------TTVTNAN 390

  Fly   453 IGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGP 517
            ...|:::.|                    :| :..|:.||..:.::..|
 Worm   391 AAESDLRSN--------------------YD-EPFSQNGTTSHKISISR---------------- 418

  Fly   518 PGGGGGGGGGGGPPEGGGDPEAAVPAHLLHP----GKVKKVKDINKLLGITPSDIDKYSRIVFPV 578
                                :|......||.    |.:....|.|...  |..::||:.|..||:
 Worm   419 --------------------QANNMFESLHALAQFGLLTDDDDENTKW--TAQNVDKFCRKAFPL 461

  Fly   579 CFVCFNLMYWIIYLH 593
            .|...||:||..||:
 Worm   462 SFCFLNLIYWCYYLY 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	53/185 (29%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	66/317 (21%)
lgc-54	NP_001343648.1	LIC	55..474	CDD:455710	129/531 (24%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	53/185 (29%)
		Cys-loop	179..193	CDD:349791	6/13 (46%)