Protein Alignment Rdl and gab-1

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_499661.2
• Gene: gab-1 / 176691
• WormBaseID: WBGene00001512
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 187/562 - (33%)
• Similarity: 274/562 - (48%)
• Gaps: 91/562 - (16%)

  Fly    58 NISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYR 122
            |.|::|....:.||.|:||.:||..:.:.:.:.:.|..|:|||.||:||..|..|:|||.||.:.
 Worm    53 NASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWS 117

  Fly   123 KRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPM 187
            ....::.:::..||.:||||||||..|:|.||.|..|..|:.:|::..|.:...:|||.|.||.|
 Worm   118 NEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSM 182

  Fly   188 NLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTG 252
            ||:.||:|.|.|.:||||:|||..::...|...|:..|: .:.::|||.:.|.....:.::..||
 Worm   183 NLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGV-EQADVPQFTITGFHTEDSIVSTATG 246

  Fly   253 NYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSST 317
            :|.||:...|..||:||::.|.|:|..|||::||||||:|..||.||||||:||||||||:.:..
 Worm   247 SYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGV 311

  Fly   318 NAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGA 382
            ..:||:||||||||:||..|||.|||:|||||.|.|.    ...::|    .|.....:..::||
 Worm   312 RQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYS----YWGRER----GKGGGGNEWPVNGA 368

  Fly   383 NQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQT 447
            |::......|.....|.|:   ..|...|.......:...|...:.....::..|...|    :.
 Worm   369 NKEDRESAVNVQKWVPSGL---MDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKP----KK 426

  Fly   448 VSNRPI-GFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKA-------HSKGG------------- 491
            .|:.|| ........:.....|...|.:.....|...|.|       |.||.
 Worm   427 RSSSPIPPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLAR 491

  Fly   492 ---TLENTVNG-GRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVK 552
               :::.:::| ||..                                  ...:|        ..
 Worm   492 MNVSMKQSISGIGRRA----------------------------------RKVIP--------TI 514

  Fly   553 KVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHV 594
            :|:|:|.        ||||||:||||||:.|||.||..|:.|
 Worm   515 RVRDVNL--------IDKYSRVVFPVCFIVFNLFYWSYYMMV 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	69/182 (38%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	99/338 (29%)
gab-1	NP_499661.2	LIC	67..545	CDD:455710	180/543 (33%)