Protein Alignment Rdl and Gabrg2

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_032099.1
• Gene: Gabrg2 / 14406
• MGIID: 95623
• Length: 474
• Species: Mus musculus
• Alignment Length: 597
• Identity: 162/597 - (27%)
• Similarity: 252/597 - (42%)
• Gaps: 167/597 - (27%)

  Fly    21 LTIWLAINMALIAQETGHKRIHTVQAATGGGSML-------GDVNISAILDSFSVSYDKRVRPNY 78
            :|:|:.:.::|....|..|.....:......:.:       |||.:  ||::....||.::||:.
Mouse    22 MTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTV--ILNNLLEGYDNKLRPDI 84

  Fly    79 GGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVP 143
            |..|..:...|||.||..::.:.|::|:|.:|.|.|.|.||.:...  ::.|.:.|..:..||:|
Mouse    85 GVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST--IKVLRLNSNMVGKIWIP 147

  Fly   144 DTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGY 208
            ||||.|.|::..|..||.|..:|:.:.|.:..::||||.|.|.:.|..||||...|.:|..|:||
Mouse   148 DTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGY 212

  Fly   209 TMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQ 273
            ...:|.|.|:.....||.:....|.||..:|.|.....:..|:|:|..::......|.|||:.||
Mouse   213 PREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQ 277

  Fly   274 IYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCF 338
            .|||..|||::||||||:|::|.|||.:||:|||||||||.:....:|||:|||.::|:::..||
Mouse   278 TYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCF 342

  Fly   339 VMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGV 403
            :.||::|:||.|:.|.....:..|.:        ::||:            ||...:
Mouse   343 IFVFSALVEYGTLHYFVSNRKPSKDK--------DKKKK------------NPLLRM-------- 379

  Fly   404 GPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGT---- 464
                                            .|...|     |:..||.. :.||.|..|
Mouse   380 --------------------------------FSFKAP-----TIDIRPRS-ATIQMNNATHLQE 406

  Fly   465 ------------RGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGP 517
                        :.|:.....|::.                       |.|...||
Mouse   407 RDEEYGYECLDGKDCASFFCCFEDC-----------------------RTGAWRHG--------- 439

  Fly   518 PGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVC 582
                                       .:|               |..:.:|.|:||.||..|..
Mouse   440 ---------------------------RIH---------------IRIAKMDSYARIFFPTAFCL 462

  Fly   583 FNLMYWIIYLHV 594
            |||:||:.||::
Mouse   463 FNLVYWVSYLYL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	60/182 (33%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	76/329 (23%)
Gabrg2	NP_032099.1	LIC	68..471	CDD:455710	152/544 (28%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	60/182 (33%)
		Cys-loop	189..203	CDD:349801	6/13 (46%)