Protein Alignment Rdl and Gabrd

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001408102.1
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 553
• Identity: 166/553 - (30%)
• Similarity: 244/553 - (44%)
• Gaps: 146/553 - (26%)

  Fly    51 GSMLG-DVNISAI--LDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQ 112
            |..:| ::.||.:  ||.....|.:..||..||.||.|.:.:.|.||..:||..|::|:..:..|
Mouse    63 GDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQ 127

  Fly   113 FWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSI 177
            .|.|.||:|....  |||.:.|.|:..:|:||||.||.|.::||..|..|:.||:...|.|..||
Mouse   128 SWRDSRLSYNHTN--ETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSI 190

  Fly   178 RLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQ 242
            |:|.|.:|.|:|..:|:|.|.|.:::||:||:..||.|:|.:....:.....::|.||.:..:|.
Mouse   191 RITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRF 255

  Fly   243 RATEINL-TTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTT 306
            ....:|. :.|.:.||:...|..|:.|.|:||.|:||.|:|.:||||||:::.|.||||:||:||
Mouse   256 TTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITT 320

  Fly   307 VLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKI 371
            ||||||||.|..::||:.|.:|::|||...|:|.|||:|:|||...:.|...:.||.:....:..
Mouse   321 VLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPR 385

  Fly   372 AEQKKQ--------QLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHG 428
            ||...:        ...|.:|:.|.......|  ||.:                     ||
Mouse   386 AEMDVRNAIVLFSLSAAGVSQELAISRRQGRV--PGNL---------------------MG---- 423

  Fly   429 HGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTL 493
                                |.|.:                      ||..|
Mouse   424 --------------------SYRSV----------------------EVEAK------------- 433

  Fly   494 ENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDIN 558
                              .:||..|||                           ||.::     :
Mouse   434 ------------------KEGGSRPGG---------------------------PGGIR-----S 448

  Fly   559 KLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIY 591
            :|..|....||.|:|.|||..|...|::||..|
Mouse   449 RLKPIDADTIDIYARAVFPAAFAAVNIIYWAAY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	65/183 (36%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	81/321 (25%)
Gabrd	NP_001408102.1	LGIC_ECD	97..280	CDD:475126	66/184 (36%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	49/87 (56%)
		TM1 helix	283..306	CDD:349857	14/22 (64%)
		TM2 helix	310..334	CDD:349857	17/23 (74%)
		TM3 helix	342..368	CDD:349857	13/25 (52%)