Protein Alignment Rdl and Gabra4

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001345970.1
• Gene: Gabra4 / 14397
• MGIID: 95616
• Length: 578
• Species: Mus musculus
• Alignment Length: 662
• Identity: 190/662 - (28%)
• Similarity: 274/662 - (41%)
• Gaps: 177/662 - (26%)

  Fly    12 MAPLPRTPLLTIWLAINMALIAQETGHKRIH------TVQAATGGGS---MLGDVNISAILDSFS 67
            |..:.:.|.:.:...:::||         :|      .:..:.|..|   .|...|.:.||||..
Mouse     1 MVSVQKVPAIALCSGVSLAL---------LHFLCLAACLNESPGQNSKDEKLCPENFTRILDSLL 56

  Fly    68 VSYDKRVRPNYG--------------------------GPPVEVGVTMYVLSISSLSEVKMDFTL 106
            ..||.|:||.:|                          ||..||...:||.|...:|:|:|::|:
Mouse    57 DGYDNRLRPGFGGTDCFKTCKCALSVRLWSACLFVEILGPVTEVKTDIYVTSFGPVSDVEMEYTM 121

  Fly   107 DFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSG 171
            |.:|||.|.|.||.| ..| :|.|.:.:..:..:|.|||||.|.|:|..|..|..|:..|:..:|
Mouse   122 DVFFRQTWIDKRLKY-DGP-IEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNG 184

  Fly   172 SITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELP--- 233
            :|..::||||:|.|||.|..||||...|.::..|:.|...::.|.|     :.|....||:|
Mouse   185 TILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-----TKGPEKSVEVPKES 244

  Fly   234 ----QFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRN 294
                |:.::|....:..|...||.|..:.......|.|||::||.|||..:.||:|.||||:|:.
Mouse   245 SSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKE 309

  Fly   295 ATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQ 359
            :.|||...|:|||||||||..|...:|||:||..::|.::..||..||::|:|:|.|.|.. .||
Mouse   310 SVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT-NIQ 373

  Fly   360 MRKQRFMAIQKIAE-----------QKKQQLDGANQQQANPN----PNANVGGPGGVGVGPGGPG 409
            |:|    |.:||::           ::|..........||.|    .||.|.....|
Mouse   374 MQK----AKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDV-------- 426

  Fly   410 GPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQ----QNVGTRGCSIV 470
              .....||         .|.....|........||..:::.|..||...    .:...||.|
Mouse   427 --KSRTEVG---------NHSSKTSAVQESSEATPKAHLASSPNPFSRANAAETMSAAARGLS-- 478

  Fly   471 GPLFQEVRFKVHDPKAH------------------SKGGTLENTVN--GGRGGPQSHGPGPGQGG 515
                     ....|..|                  |:.|.::.|||  |..|...:..|.|..
Mouse   479 ---------SAASPSPHGTLRPASLGSASTRPAFGSRLGRIKTTVNTTGAAGNVSATPPPPAP-- 532

  Fly   516 GPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCF 580
                          ||.|.|                             .|.||||:||:|||.|
Mouse   533 --------------PPSGSG-----------------------------TSKIDKYARILFPVTF 554

  Fly   581 VCFNLMYWIIYL 592
            ..||::||::||
Mouse   555 GAFNMVYWVVYL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	64/189 (34%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	95/352 (27%)
Gabra4	NP_001345970.1	LIC	13..565	CDD:455710	186/647 (29%)
		LGIC_ECD_GABAAR_A4	57..281	CDD:349838	72/230 (31%)
		Cys-loop	198..212	CDD:349838	8/13 (62%)