Protein Alignment Rdl and Gabra3

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001344745.1
• Gene: Gabra3 / 14396
• MGIID: 95615
• Length: 523
• Species: Mus musculus
• Alignment Length: 547
• Identity: 160/547 - (29%)
• Similarity: 234/547 - (42%)
• Gaps: 151/547 - (27%)

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            |||.....||.|:||..|....||...:||.|...:|:..|::|:|.:|||.|.|.||   |..|
Mouse   101 ILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERL---KFDG 162

  Fly   127 -VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQ 190
             ::.|.:.:.....||.|||||.|.|:|..|..||.|:.:|:..:|::..::||||.|.|||:|:
Mouse   163 PMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLE 227

  Fly   191 YFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVE-------LPQFRVLGHRQRATEIN 248
            .||||...|.::..|:.||..::.|.|     ::|.:..||       |.|:.:|||......|.
Mouse   228 DFPMDVHACPLKFGSYAYTKAEVIYSW-----TLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIR 287

  Fly   249 LTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTL 313
            .:||.|..:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||
Mouse   288 SSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTL 352

  Fly   314 MSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQ 378
            ..|...:|||::|..::|.::..|:..||::|:|:|||.|..||....:.:  .:.:..|.||:.
Mouse   353 SISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGK--KVPEALEMKKKT 415

  Fly   379 LDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHA 443
                                                                          |.|
Mouse   416 --------------------------------------------------------------PAA 418

  Fly   444 P--KQTVSNRPIGFSNIQQNVGTRGCSIVGP-----LFQEVRFKVHDPKAHSKGGTLENTVNGGR 501
            |  |.|..|                  |||.     |.::..|               :|::...
Mouse   419 PTKKNTTFN------------------IVGTTYPINLAKDTEF---------------STISKSA 450

  Fly   502 GGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPS 566
            ..|.:                     ...|.....|:|.....  .|.:.|....::|
Mouse   451 AAPSA---------------------SSTPTAIASPKATYVQD--SPAETKTYNSVSK------- 485

  Fly   567 DIDKYSRIVFPVCFVCFNLMYWIIYLH 593
             :||.|||:|||.|..|||:||..|::
Mouse   486 -VDKISRIIFPVLFAIFNLVYWATYVN 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	66/190 (35%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	77/320 (24%)
Gabra3	NP_001344745.1	LIC	100..509	CDD:455710	159/543 (29%)
		LGIC_ECD_GABAAR_A3	106..305	CDD:349837	72/206 (35%)
		Cys-loop	222..236	CDD:349837	8/13 (62%)