Protein Alignment Rdl and Gabra2

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_032092.1
• Gene: Gabra2 / 14395
• MGIID: 95614
• Length: 451
• Species: Mus musculus
• Alignment Length: 582
• Identity: 167/582 - (28%)
• Similarity: 245/582 - (42%)
• Gaps: 153/582 - (26%)

  Fly    20 LLTIWLAINMALI-AQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPV 83
            :|.:|..:.:.|. .||...|...|:              .:.|||.....||.|:||..|....
Mouse    16 VLLVWDPVRLVLANIQEDEAKNNITI--------------FTRILDRLLDGYDNRLRPGLGDSIT 66

  Fly    84 EVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFV 148
            ||...:||.|...:|:..|::|:|.:|||.|.|.||.: |.| :..|.:.:.....||.|||||.
Mouse    67 EVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKF-KGP-MNILRLNNLMASKIWTPDTFFH 129

  Fly   149 NEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDI 213
            |.|:|..|..|..|:.:|:...|::..::|||:.|.|||:|:.||||...|.::..|:.||..::
Mouse   130 NGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEV 194

  Fly   214 RYFWRDGLS-SVGMSSE-VELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYI 276
            .|.|....| ||.::.: ..|.|:.:||.......|..:||.|:.:.......|.:||::||.|:
Mouse   195 TYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYL 259

  Fly   277 PSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMV 341
            |..:.||:|.|||||||.:.|||...|||||||||||..|...:|||::|..::|.::..|:..|
Mouse   260 PCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFV 324

  Fly   342 FASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPG 406
            |::|:|:|||.|..|    |...:.....:.::||::.....|..|.....||
Mouse   325 FSALIEFATVNYFTK----RGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVAN------------ 373

  Fly   407 GPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVG 471
                                               :||  .:|..|: .|.|.::..|
Mouse   374 -----------------------------------YAP--NLSKDPV-LSTISKSATT------- 393

  Fly   472 PLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGD 536
                                                                       ||....
Mouse   394 -----------------------------------------------------------PEPNKK 399

  Fly   537 PEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVV 598
            ||.       .|.:.||.  .|.:     |.||:.|||||||.|..|||:||..||:...|:
Mouse   400 PEN-------KPAEAKKT--FNSV-----SKIDRMSRIVFPVLFGTFNLVYWATYLNREPVL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	63/184 (34%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	78/313 (25%)
Gabra2	NP_032092.1	LIC	25..440	CDD:455710	162/564 (29%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	70/203 (34%)
		Cys-loop	166..180	CDD:349836	8/13 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		6/91 (7%)