Protein Alignment Rdl and Gabra5

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_795916.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 541
• Identity: 158/541 - (29%)
• Similarity: 238/541 - (43%)
• Gaps: 140/541 - (25%)

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            |||.....||.|:||..|....:|...:||.|...:|:.:|::|:|.:|||.|.|.||.: |.|
Mouse    52 ILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRF-KGP- 114

  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191
            ::.|.:.:.....||.|||||.|.|:|..|..||.|:.:|:...|::..::||||:|.|||.|:.
Mouse   115 MQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLED 179

  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSE--VELPQFRVLGHRQRATEINLTTGNY 254
            ||||...|.::..|:.|...::.|.|.:|.:...:.:|  ..|.|:.::|.......|:.:||.|
Mouse   180 FPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEY 244

  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319
            :.:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...
Mouse   245 TIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 309

  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKR-IQMRKQRFMAIQKIAEQKKQQLDGAN 383
            :|||::|..::|.::..|:..||::|:|:|||.|..|| .....::.:...||.:::::.:
Mouse   310 SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELI---- 370

  Fly   384 QQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTV 448
               .|.:.||...|                                     ..:| .|:.||:
Mouse   371 ---LNKSTNAFTTG-------------------------------------KLTH-PPNIPKE-- 392

  Fly   449 SNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPK-AHSKGGTLENTVNGGRGGPQSHGPGPG 512
             ..|.|.:|.                ..|..|..:.| |.||
Mouse   393 -QPPAGTANA----------------PTVSIKASEEKTAESK----------------------- 417

  Fly   513 QGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFP 577
                                                      |..|.:     |.|||.||||||
Mouse   418 ------------------------------------------KTYNSI-----SKIDKMSRIVFP 435

  Fly   578 VCFVCFNLMYWIIYLHVSDVV 598
            :.|..|||:||..||:...|:
Mouse   436 ILFGTFNLVYWATYLNREPVI 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	61/184 (33%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	78/315 (25%)
Gabra5	NP_795916.1	LIC	15..449	CDD:455710	155/532 (29%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	67/199 (34%)
		Cys-loop	173..187	CDD:349839	8/13 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		7/39 (18%)