DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5653 and Smox

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006235125.1	Gene:	Smox / 308652	RGDID:	1306049	Length:	585	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	167/590 - (28%)
Similarity:	243/590 - (41%)	Gaps:	159/590 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RASSRIIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTVYFGDNVIDLGAQWCHGKQQ 69
            |...|:::||||::|:|||..||:..|.:|.:|||...||||:.:|..|....:|||.|.||...
  Rat    22 RGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHG 86

  Fly    70 NCVYDMVKDMGILHETGDYYSPIKRVRSNKEVVPHELACRIHDIAVKSMPSGPHPVVGSFGT--- 131
            |.:|.:.:..|:|.||.|....:.|:....:   :.:||.:.:...:.    |..||..|..
  Rat    87 NPIYQLAEANGLLEETTDGERSVGRISLYSK---NGVACYLTNRGRRI----PKDVVEEFSDLYN 144

  Fly   132 ---HLTQTFWR-------------------KIESEL------PQVNRDVASEALNTFAKHESSII 168
               :|||.|:|                   |:.:.:      .:..:.:....:..:.|.||...
  Rat   145 EVYNLTQEFFRNGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCES 209

  Fly   169 GADNLFEVSVREHIEYHECDGDKLLHWGTKGYRRFLRLLMKVSADTPEELGLLEGRIQLDMKVIK 233
            .:.::.|||:....|:.|..|..  |....|:.|.:.||.|         |:....|||...|..
  Rat   210 SSHSIDEVSLSAFGEWTEIPGAH--HIIPSGFMRVVELLAK---------GIPPHVIQLGKPVRC 263

  Fly   234 IE----LACPR-------------------------------------KVILRCQDGDYFEADHV 257
            |.    .|.||                                     .|::.|:|.:...||||
  Rat   264 IHWDQASARPRGPEIEPRGEGDHNHDAGEGGQSGENPQQGRWDEDEQWPVVVECEDCEVIPADHV 328

  Fly   258 ICTVSLGVLQEQHEKLFVPPLPAAKVNAIRSLTLGTVNKLYLEYEKQPLPDGWVGFFCFW----- 317
            |.|||||||:.|:...|.|.||..||.||..|.:||.:|::||:|:.           ||
  Rat   329 IVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEP-----------FWGPECN 382

  Fly   318 ----LEEDLIELRKTEY---FWVEGITGVHMITCQPR---MLMAWVNGPHGRHMETLSDEKVLEG 372
                :.||..|.....|   .|...|.|..::....|   :|..|:.|.....||...||.|.|.
  Rat   383 SLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEI 447

  Fly   373 LYWLFRKFL-TFEIPPPKRFVRSSWFSNPNFRGSWSYRGVMADERNTGPWDLE------------ 424
            ...:.|:|. ...||.|:|.:||:|.|||.||||:||..|     .:...|:|
  Rat   448 CTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQV-----GSSGADVEKLAKPLPYTESS 507

  Fly   425 -----SPVLGEDGHL--------------------GLLFAGEASSRNHFSTVHGAVEAGYREADR 464
                 |....:.|||                    .:||:|||:.|.::||.|||:.:|.|||.|
  Rat   508 KTAHGSSTKQQPGHLLSSKCPEQSLDPSRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREAAR 572

  Fly   465 LIDHY 469
            ||:.|
  Rat   573 LIEMY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	29/65 (45%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	158/573 (28%)
Smox	XP_006235125.1	NAD_binding_8	<45..88	CDD:290186	17/42 (40%)
Smox	XP_006235125.1	PLN02568	50..578	CDD:215308	154/562 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343429
Domainoid	1	1.000	138	1.000	Domainoid score	I4710
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	O	PTHR10742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750