DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5653 and Paox

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_722478.2	Gene:	Paox / 212503	MGIID:	1916983	Length:	504	Species:	Mus musculus

Alignment Length:	527	Identity:	169/527 - (32%)
Similarity:	248/527 - (47%)	Gaps:	102/527 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RIIIIGAGVSGIAAATRLLQNN-FQNVQILEAEDRIGGRINTVYFGDNVIDLGAQWCHG-KQQNC 71
            |::::|:|::|:.||.:|..:. ..::::|||....||||.:......|::|||.|.|| .|.|.
Mouse     7 RVLVVGSGIAGLGAAQKLCSHRAAPHLRVLEATASAGGRIRSERCFGGVVELGAHWIHGPSQDNP 71

  Fly    72 VYDMVKDMGILHETGDYYSPIKRVRSNKEVVP---HELACRIHDIAVKSM--PSGPHPVVGSFGT 131
            |:.:..:.|:|.|        |.:....::|.   |        :|:.||  .|....|.....|
Mouse    72 VFQLAAEFGLLGE--------KELSEENQLVDTGGH--------VALPSMIWSSSGTSVSLELMT 120

  Fly   132 HLTQTFWRKI--------ESELP----------QVNRDVAS-------------EALNTFAKHES 165
            .:.:.|:..|        |||.|          ::::.|||             ..||||...|.
Mouse   121 EMARLFYGLIERTREFLNESETPMASVGEFLKKEISQQVASWTEDDEDTRKRKLAILNTFFNIEC 185

  Fly   166 SIIGADNLFEVSVREHIEYHECDG-DKLLHWGTKGYR-RFLRLLMK--VSADTPEELGLLEGRIQ 226
            .:.|..::..|::....||....| |.:|..|.:|.. |.|..|.|  |:.|.|.:.....|..|
Mouse   186 CVSGTHSMDLVALAPFGEYTVLPGLDCILAGGYQGLTDRILASLPKDTVAFDKPVKTIHWNGSFQ 250

  Fly   227 LDMKVIKIELACPRK---VILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKVNAIRS 288
                    |.|.|.:   |::.|:||....|.|||.||.||.|:|..:..|.|||||.|..||:.
Mouse   251 --------EAAFPGETFPVLVECEDGARLPAHHVIVTVPLGFLKEHQDTFFEPPLPAKKAEAIKK 307

  Fly   289 LTLGTVNKLYLEYEKQPL--PDGWVGFFCFWLE---EDLIELRKT----EYFWVEGITGVHMITC 344
            |..||.||::||:| :|.  ||      |.:::   ||...|:.|    :..|.:.:.|   ...
Mouse   308 LGFGTNNKIFLEFE-EPFWEPD------CQFIQVVWEDTSPLQDTALSLQDTWFKKLIG---FLV 362

  Fly   345 QP-----RMLMAWVNGPHGRHMETLSDEKVLEGLYWLFRKFL-TFEIPPPKRFVRSSWFSNPNFR 403
            ||     .:|..::.|.....|||||||:||..|..:.|:.. ..::|..|...||.|.|.|..|
Mouse   363 QPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGNPQLPAAKSVRRSQWHSAPYTR 427

  Fly   404 GSWSYRGVMADERNTG-PWDLESPVLGEDG---HLGLLFAGEASSRNHFSTVHGAVEAGYREADR 464
            ||:||..|    .:|| ..||.:..|.|||   .|.:||||||:.|..:||.|||:.:|:|||||
Mouse   428 GSYSYVAV----GSTGDDLDLMAQPLPEDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREADR 488

  Fly   465 LIDHYTS 471
            |:..:.|
Mouse   489 LVSLWDS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	23/67 (34%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	164/512 (32%)
Paox	NP_722478.2	PLN02568	6..490	CDD:215308	167/520 (32%)
		NAD_binding_8	10..79	CDD:290186	23/68 (34%)
		Microbody targeting signal. /evidence=ECO:0000255	502..504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650