Protein Alignment TrpA1 and LOC1279693

DIOPT Version :10

• Sequence 1: NP_001261600.1
• Gene: TrpA1 / 39015
• FlyBaseID: FBgn0035934
• Length: 1232
• Species: Drosophila melanogaster
• Sequence 2: XP_061516912.1
• Gene: LOC1279693 / 1279693
• VectorBaseID: AGAMI1_000842
• Length: 1126
• Species: Anopheles gambiae
• Alignment Length: 1254
• Identity: 292/1254 - (23%)
• Similarity: 458/1254 - (36%)
• Gaps: 309/1254 - (24%)

  Fly    65 DGDDADTPLEAILPAEPPAEVCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAA 129
            |.|....|.....|:.||.....:    ||.:...|:|:: .|.||....|:  .||...|....
Mosquito     8 DSDSTTAPSPLPPPSTPPVRPPRI----FRTISCIENGSI-KFPRLSSRFNA--TLKKDTGEQPI 65

  Fly   130 HQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAP 194
            ...||.:..     :.::||..|  :|:..|   ..::::..|         |..|:  .:..|.
Mosquito    66 DPEAALSET-----LMNENGPRN--ENSTKT---ANIQNNISD---------VTAGI--RRSSAD 109

  Fly   195 VHLATELNKVKSLRVMGQYRNVIDIQ---------QGGEHGRTALHLAAIYDHEECARILITEFD 250
            .|      .|.:..|.|.:....:..         .|..:||.:        |.:|...:    :
Mosquito   110 NH------NVSAATVNGSFTTTTNTNTKTTASHSGTGQPNGRKS--------HVDCYEYM----E 156

  Fly   251 ACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYD----SEGNVPLHSAVHG 311
            ..|..|.        |.|.|......|.:.:...|. |.....||..:    :.|.|.|..:...
Mosquito   157 VGPSPPA--------EGAPNLYDSYDESYSESSAQL-CNDIIRISLTEQMRLAGGRVALLESFEL 212

  Fly   312 G---DIKAVELCLKSGAKISTQQHDLSTPV------HLACAQGAIDIVKLMFEMQPMEKRLC--- 364
            .   |..|||..|...|.::|.....:|..      :..|..|           |.:||.:|
Mosquito   213 DLTLDCAAVEHLLNGTATLATSGPATNTSTTTFPTNNSVCVGG-----------QQLEKNICFLW 266

  Fly   365 -------------------LSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLL 410
                               ::..|...:|.||.||.....:..::|:..|.|:|...|.: :||.
Mosquito   267 AAFLRKFHLLDQCVRLGADINFCDSNGLTALHLASFSGCTECCAFLIQHGLDVNMQPKWY-TPLH 330

  Fly   411 LAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEK 475
            .||..:...|..|||:                     ||.|: |......:|:.
Mosquito   331 CAAFGNSLATAELLIK---------------------NGARI-DVPTNKQHCEE----------- 362

  Fly   476 DSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFI 540
                 |.||.|.|...|..|...|..|:.:|....|..:|:|.||..|....:..||:.......
Mosquito   363 -----SLLHCAVRSNAIDCLRFFIAHGSNVNALERNGTNPIHLAADLGHTQCLAALLECPNADPN 422

  Fly   541 INESDG-AGMTPLHISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLHSVH 603
            |....| ..||.||:::.:|:...|..||.||| :..|:|.|..||.|||.||..:.:|.|..:.
Mosquito   423 IRIQQGDKQMTALHLAADEGNLDCVTQLLARGADVRARNHRGFTPLHLAARSGSADCVEALLKLG 487

  Fly   604 SHLLDQVDKDGNTALHLATMENKP--HAISVLMSMGCKL----VY--NVLDMSAID-------YA 653
            ....:..|.|..|.||.|..::..  ..|..|::.|..:    ||  ..|.::|:|       ..
Mosquito   488 GCDPNMADFDQRTPLHAAVSKSDTAVEMIETLIAWGANVNQRDVYGFTALHLAALDALGPCVETL 552

  Fly   654 IYYKYPEAALAMVTHEER-ANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKS 717
            :|:.      |.||.:.| ....:.:.|.|.|       ||: .|.:...|..||..: .:||.|
Mosquito   553 LYHG------ADVTMKSRKGTSALNIISRKTP-------ASL-GVIQCKLDAAITLTH-SQDSSS 602

  Fly   718 FYIKYSFAFLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNS 782
            ..::....|...              :....|..:..|||.|..|:.|.|.|||...:|.:|||.
Mosquito   603 REVELELDFRSI--------------LQHCHPREISYLNTFVDDGQKEFLQHPLCSAFLYIKWNK 653

  Fly   783 YGKYFHLANLLIYSIFLVFVTIY-SSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSV-A 845
            ..||: :|.||....|::|:|:| .:.:.:|....:.|.|...|      ||   .|.|..|: .
Mosquito   654 IRKYY-IARLLFCFTFVLFLTLYVLTALAHNCYNGSKDMKETIQ------EQ---ELCQKQSIFG 708

  Fly   846 SQIRLDSCEERINRTTAILFCAVVIVVYILLNSMRELIQI--YQQKLHYILETVNLISWVLYISA 908
            ..:|        |....|....:|:|....:...|::..|  |....||:.:|.|.|.|.:.:|.
Mosquito   709 DMLR--------NNPFVIEMQWMVLVAITAIEICRKIYGITGYTSLKHYVTQTENAIEWFIILSV 765

  Fly   909 LVMV------TPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIK 967
            .|:.      |..:|...|         :.||.|.|..|:|.:.:....|.||.|:.::.....|
Mosquito   766 FVISYIYTKRTYTWQNHVG---------AFAVLLGWTNLMLMIGQLPVFGAYVAMYTKVQVEFAK 821

  Fly   968 VLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRD- 1031
            :.|.:|.::|.|.::|.::.       |:..||:|..|..:....||.||.|......:...:|
Mosquito   822 LFMAYSCMLIGFTISFCVIF-------PSSSSFANPFMGFITVLVMMTGEQDLELLINDPDGKDP 879

  Fly  1032 QLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVW 1096
            ...:.:::.:...:|::.:.::|||||||:||.||:.:::.|.|.:|..|..|.:.:|..|.:.|
Mosquito   880 PFLLEISAQITFVLFLLFVTVILMNLLIGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGW 944

  Fly  1097 LQRVDKMELIEYPNETKCKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRKL- 1160
            |           ||               |..|..                |..|.:..|..::
Mosquito   945 L-----------PN---------------WLRNLL----------------YYTALVSPQAYRVV 967

  Fly  1161 --------------RDIS----RMLEQQHHLVRLIVQKMEIKTEADDVDEGISPNELRSVVGLRS 1207
                          |||.    .:.:|:.|.||     ....|...||......|.| .|.|::|
Mosquito   968 LSVKPLNPGETRLPRDIMMAAYEVAKQKKHYVR-----KSFSTLRRDVSYDPQKNAL-IVNGMQS 1026

  Fly  1208 AGGNRWNSP-RVRNKLRAA 1225
            ....|.:|. .|.|..|||
Mosquito  1027 KTYKRTDSSCNVSNCRRAA 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..183	CDD:463710	17/87 (20%)
		ANK repeat	125..155	CDD:293786	6/29 (21%)
		ANKYR	140..461	CDD:440430	68/364 (19%)
		ANK repeat	157..199	CDD:293786	6/41 (15%)
		ANK repeat	259..298	CDD:293786	8/38 (21%)
		ANK repeat	300..330	CDD:293786	9/32 (28%)
		ANK repeat	336..369	CDD:293786	7/60 (12%)
		ANKYR	368..634	CDD:440430	74/269 (28%)
		ANK repeat	374..402	CDD:293786	9/27 (33%)
		ANK repeat	404..476	CDD:293786	13/71 (18%)
		ANK repeat	478..509	CDD:293786	10/30 (33%)
		TRPV	481..1093	CDD:454755	172/640 (27%)
		ANK repeat	511..545	CDD:293786	9/33 (27%)
		ANK repeat	547..576	CDD:293786	11/29 (38%)
		ANK repeat	579..611	CDD:293786	10/31 (32%)
		ANK repeat	613..638	CDD:293786	7/26 (27%)
LOC1279693	XP_061516912.1	None