DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm7 and mcm-2

DIOPT Version :9

Sequence 1:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001022416.1	Gene:	mcm-2 / 174841	WormBaseID:	WBGene00003154	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	234/709 - (33%)
Similarity:	354/709 - (49%)	Gaps:	119/709 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RDYAQD-------RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNES 61
            ||:..|       ....|.||..|   .:.|.|:..|...:..:|...:..:.:...||::
Worm   156 RDHVSDEAVAKEIERRFKNFLRSF---HEPGNKQTKYIQMIKSMAADNRESLEVSFTDLSD---- 213

  Fly    62 LAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKD--ALDVYIEHRLMMESRTRNPMEQRDERN 124
                  ||..:..|.|       ||....:.:...|  |.:|.:                    |
Worm   214 ------DNGEQNISYF-------LPEAPNEMLAIMDRAATEVVM--------------------N 245

  Fly   125 SFP--SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRC 187
            .:|  |.:....:|....|..|:  .||.::..|:..|:...|:||..:.:.|.:.|..|.|..|
Worm   246 MYPFYSRVCNEIKVRISQLPVEE--DIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVAC 308

  Fly   188 G----------SETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSD 242
            |          .|..:|.         .|||  |   :..|...|....:.:..:|.:.|||..:
Worm   309 GYLLGPFVQQNDEEVRPT---------ICPS--C---QGKGPFELNVENTVYHNYQRITMQESPN 359

  Fly   243 QVPVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGL-LSETFLQAHRIICI 306
            :|..|.:|||..::..|::....:|||.|.|:||:.... .|.....||. :..|.:.|:.|  .
Worm   360 KVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNF-DGSLNYKQGFPVFNTLIHANHI--T 421

  Fly   307 NKNDEISDKDAELTPEELE---ELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPD 367
            ||:...||   :||.|:::   ||:|| :..:|:.:|:||.||||.|||:|:.|.|..|..|.|.
Worm   422 NKDKMASD---QLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPG 483

  Fly   368 GM-KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEG 431
            .. ::||:||:.|.||||.||||.|.|.:.:|.||..|||:|:|.|||||.|.:.|:|.|.|||.
Worm   484 AKHRLRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEA 548

  Fly   432 GALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYN 496
            ||:||||:|||.|||||||:|||||:|||.||||:|||:||||:|:|:||.:::||:||..||||
Worm   549 GAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYN 613

  Fly   497 PRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPP------------- 548
            |.||..:|:.|...:|||||:|.:|:|..|...|.||||.:  |.:|....|
Worm   614 PTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFV--VGNHRTHHPDAKKIVKEGDELE 676

  Fly   549 -------TRVKALDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARN 605
                   |.|:.:..:|:|:||...:.| :||:|::.::.....:.::|:|:.....:..| .|:
Worm   677 EDQMDERTGVRLIPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVAIT-VRH 740

  Fly   606 LLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFA 664
            :..::|||.|.|:|.|...|..:|.|.|:|::      |......||..:.....:.|:
Worm   741 VESMIRLSEAHAKLHLRSYVNDEDCAAAIRVM------LESFVNTQKASIMRMMKKTFS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	16/83 (19%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	202/532 (38%)
mcm-2	NP_001022416.1	MCM2_N	48..>103	CDD:289392
		MCM_N	171..286	CDD:291233	29/156 (19%)
		MCM	270..777	CDD:214631	203/535 (38%)
		AAA	461..639	CDD:99707	105/177 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920