Protein Alignment Mcm7 and mcm-2

DIOPT Version :10

• Sequence 1: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001022416.1
• Gene: mcm-2 / 174841
• WormBaseID: WBGene00003154
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 709
• Identity: 234/709 - (33%)
• Similarity: 354/709 - (49%)
• Gaps: 119/709 - (16%)

  Fly     4 RDYAQD-------RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNES 61
            ||:..|       ....|.||..|   .:.|.|:..|...:..:|...:..:.:...||::
 Worm   156 RDHVSDEAVAKEIERRFKNFLRSF---HEPGNKQTKYIQMIKSMAADNRESLEVSFTDLSD---- 213

  Fly    62 LAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKD--ALDVYIEHRLMMESRTRNPMEQRDERN 124
                  ||..:..|.|       ||....:.:...|  |.:|.:                    |
 Worm   214 ------DNGEQNISYF-------LPEAPNEMLAIMDRAATEVVM--------------------N 245

  Fly   125 SFP--SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRC 187
            .:|  |.:....:|....|..|:  .||.::..|:..|:...|:||..:.:.|.:.|..|.|..|
 Worm   246 MYPFYSRVCNEIKVRISQLPVEE--DIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVAC 308

  Fly   188 G----------SETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSD 242
            |          .|..:|.         .|||  |   :..|...|....:.:..:|.:.|||..:
 Worm   309 GYLLGPFVQQNDEEVRPT---------ICPS--C---QGKGPFELNVENTVYHNYQRITMQESPN 359

  Fly   243 QVPVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGL-LSETFLQAHRIICI 306
            :|..|.:|||..::..|::....:|||.|.|:||:.... .|.....||. :..|.:.|:.|  .
 Worm   360 KVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNF-DGSLNYKQGFPVFNTLIHANHI--T 421

  Fly   307 NKNDEISDKDAELTPEELE---ELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPD 367
            ||:...||   :||.|:::   ||:|| :..:|:.:|:||.||||.|||:|:.|.|..|..|.|.
 Worm   422 NKDKMASD---QLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPG 483

  Fly   368 GM-KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEG 431
            .. ::||:||:.|.||||.||||.|.|.:.:|.||..|||:|:|.|||||.|.:.|:|.|.|||.
 Worm   484 AKHRLRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEA 548

  Fly   432 GALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYN 496
            ||:||||:|||.|||||||:|||||:|||.||||:|||:||||:|:|:||.:::||:||..||||
 Worm   549 GAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYN 613

  Fly   497 PRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPP------------- 548
            |.||..:|:.|...:|||||:|.:|:|..|...|.||||.:  |.:|....|
 Worm   614 PTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFV--VGNHRTHHPDAKKIVKEGDELE 676

  Fly   549 -------TRVKALDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARN 605
                   |.|:.:..:|:|:||...:.| :||:|::.::.....:.::|:|:.....:..| .|:
 Worm   677 EDQMDERTGVRLIPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVAIT-VRH 740

  Fly   606 LLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFA 664
            :..::|||.|.|:|.|...|..:|.|.|:|::      |......||..:.....:.|:
 Worm   741 VESMIRLSEAHAKLHLRSYVNDEDCAAAIRVM------LESFVNTQKASIMRMMKKTFS 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	19/94 (20%)
		MCM	145..641	CDD:475121	202/532 (38%)
mcm-2	NP_001022416.1	MCM2_N	48..>116	CDD:403724
		MCM_N	169..262	CDD:464206	23/132 (17%)
		MCM	270..777	CDD:214631	203/535 (38%)