Protein Alignment rhea and SLA2

DIOPT Version :10

• Sequence 1: NP_648238.1
• Gene: rhea / 38978
• FlyBaseID: FBgn0260442
• Length: 2836
• Species: Drosophila melanogaster
• Sequence 2: NP_014156.2
• Gene: SLA2 / 855478
• SGDID: S000005187
• Length: 968
• Species: Saccharomyces cerevisiae
• Alignment Length: 1315
• Identity: 253/1315 - (19%)
• Similarity: 446/1315 - (33%)
• Gaps: 445/1315 - (33%)

  Fly  1309 SHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAKNLLHAAARGVTESINQLVDASIQSAPGQKEC 1373
            |.:...|:....::||:..||         |..|::............::.|..::::.|
Yeast     2 SRIDSDLQKALKKACSVEETA---------PKRKHVRACIVYTWDHQSSKAVFTTLKTLP----- 52

  Fly  1374 DNAMRNIEA-LRLMLDYPHEPINELGYFDCVEQA---------TGKSRNLGYAISEMINN----- 1423
               :.|.|. |..||...|:.|.| |:...:.:|         .|:..:.|.:.|::|..
Yeast    53 ---LANDEVQLFKMLIVLHKIIQE-GHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYL 113

  Fly  1424 -AKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGIIDQAQLTWAYQGIRQ- 1486
             .|...|.. .:..||      |..|.....: |:.||.|..  |...|:|...|..:.....|
Yeast   114 VLKLDFHAH-HRGFNN------GTFEYEEYVS-LVSVSDPDE--GYETILDLMSLQDSLDEFSQI 168

  Fly  1487 -HCDIVSSQQSTKPQMISALTVIAKH---TSYLCSICRQASMNTSNPVAKNEFIVLAKQVATATS 1547
             ...|.|.:::|:.::.:.:.:||:.   ..::.|:.|                .:.:|:..|..
Yeast   169 IFASIQSERRNTECKISALIPLIAESYGIYKFITSMLR----------------AMHRQLNDAEG 217

  Fly  1548 D-LVQDIKAIEEQSAGGSRERLVDPLLEAVKAVRQYASSSEFSSVPAKISAEGRKAQEPVIQAGR 1611
            | .:|.:|...|              |:..:....||..|....:...::........|.:
Yeast   218 DAALQPLKERYE--------------LQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDV---- 264

  Fly  1612 GVIDGVVE-----------MVKAAKSLALTP-DNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPG 1664
            .:|:.|.|           .|..|::.|.|| ..|||..:.::...|||:.............|.
Yeast   265 FLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPT 329

  Fly  1665 QAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKN 1729
            .|       |.|.........|.|:..|..:|.:.:   .::.|....|:|            :|
Yeast   330 GA-------TTGMMIPTATGAANAIFPQATAQMQPD---FWANQQAQFANE------------QN 372

  Fly  1730 NAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPR 1794
            ..||  ..|.::.:                  .|.|..|.||.          :|.|::...|.:
Yeast   373 RLEQ--ERVQQLQQ------------------QQAQQELFQQQ----------LQKAQQDMMNMQ 407

  Fly  1795 ATHAHPRLDDAIDGTRE------AIQELQQTVEKINAETGI---------------VTGLMEQVN 1838
            ....:...:|.|..|.:      .:|:..|.|:::.:|...               :|.|.:|::
Yeast   408 LQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLD 472

  Fly  1839 ------RSITRL-TDKRQSLLNASYSDTFVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLA 1896
                  .|:.:| :..||..||             ::.|.|::....|  :|:.|::..
Yeast   473 VWERKYESLAKLYSQLRQEHLN-------------LLPRFKKLQLKVN--SAQESIQKK------ 516

  Fly  1897 VDMTQNYQQLTQDSVGASTTTSSPDVAMRIRTTVIDLGRSVSSMIQSSAGGARPNDAGAQKEIAR 1961
               .|...:|.|..:..:......|.|.      ::|.||:             |:|.|....|.
Yeast   517 ---EQLEHKLKQKDLQMAELVKDRDRAR------LELERSI-------------NNAEADSAAAT 559

  Fly  1962 SARE--VSEKVAQVL-AALQAGSRGTQACINAAHTVSGIIGDLDTTIMFA---TAGTLHSDGDGS 2020
            :|.|  ..:|:..:| |.|::|       ||   |:...:.:||:.:.::   |..|.
Yeast   560 AAAETMTQDKMNPILDAILESG-------IN---TIQESVYNLDSPLSWSGPLTPPTF------- 607

  Fly  2021 FADHREHILQTAKALVEDTKVLVTGAAGTQDQLANAAQNAVSTITQLAEAVKRGACSLGSTQPDS 2085
                       ..:|:|.|.             .||.:.|.|....:.:.:..|          .
Yeast   608 -----------LLSLLESTS-------------ENATEFATSFNNLIVDGLAHG----------D 638

  Fly  2086 QVMVINAVKDVASALGDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTR 2150
            |..||:.|.|.::::..|:..:|..:..::  |..|.            ..:|..||       |
Yeast   639 QTEVIHCVSDFSTSMATLVTNSKAYAVTTL--PQEQS------------DQILTLVK-------R 682

  Fly  2151 GTRAMEATVEAISQEIRAMHSPPPVGNTQVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAA 2215
            ..|..:...|.:..|          ...|||.|:                       :.|||..|
Yeast   683 CAREAQYFFEDLMSE----------NLNQVGDEE-----------------------KTDIVINA 714

  Fly  2216 NLGRRAISEMLIVCRSVAWNCAETEELRSRTLEAGTAVGESYRDLLSGILHNCSADDRMHLSRRV 2280
            |:                       :::.:..|...|:    ..||:
Yeast   715 NV-----------------------DMQEKLQELSLAI----EPLLN------------------ 734

  Fly  2281 AKCVTDLVAMARLLKGSDWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDEN 2345
                      .:.:|.:...:|       .:||:..|..|                   ::..|:
Yeast   735 ----------IQSVKSNKETNP-------HSELVATADKI-------------------VKSSEH 763

  Fly  2346 MKFD--EMILEAAKGIMGASAALVRAANAAQRELIDTGKVARRPLTS--SDDGQWSEGLISAARL 2406
            ::.|  :.:|..|..|:.|..|||:||...|.|:..|..:   ||..  ..:.:|:|||||||:.
Yeast   764 LRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSI---PLNQFYLKNSRWTEGLISAAKA 825

  Fly  2407 VAAATHSLVEAAQNLVRGVGTE----EMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQ--- 2464
            ||.||:.|:..|..|:.....|    |..|..:|:|||||.||:.|.:||::.:|:|..:|:
Yeast   826 VAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCS 890

  Fly  2465 --------AAGNAVIK--STDNLVHSAQQGLEAEEEHSLKINTSMVDGMAQEINARSAVLRKEKE 2519
                    :.||.|:.  ..|:.....||.|:...||:||         ..|:..:..:|:.|:.
Yeast   891 KDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLK---------TAEMEQQVEILKLEQS 946

  Fly  2520 LEEARQLLKNV-RHA 2533
            |..||:.|..: |||
Yeast   947 LSNARKRLGEIRRHA 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_648238.1	FERM_f0	4..85	CDD:465152
		FERM_F1_TLN	88..205	CDD:340610
		B41	89..322	CDD:214604
		FERM_C_Talin	318..409	CDD:269973
		Talin_middle	510..668	CDD:462691
		ILWEQ	622..>768	CDD:214607
		Vinculin	<874..>1035	CDD:460040
		talin-RS	1661..1832	CDD:213393	30/191 (16%)
		VBS	1859..1982	CDD:430312	24/125 (19%)
		I_LWEQ	2392..2533	CDD:460265	51/158 (32%)
SLA2	NP_014156.2	ANTH	7..269	CDD:400137	57/323 (18%)
		DR0291	420..>546	CDD:441187	25/155 (16%)
		ILWEQ	763..965	CDD:214607	68/211 (32%)