Protein Alignment GstO3 and CLIC3

DIOPT Version :10

• Sequence 1: NP_648234.1
• Gene: GstO3 / 38972
• FlyBaseID: FBgn0035904
• Length: 241
• Species: Drosophila melanogaster
• Sequence 2: NP_004660.2
• Gene: CLIC3 / 9022
• HGNCID: 2064
• Length: 236
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 50/226 - (22%)
• Similarity: 87/226 - (38%)
• Gaps: 68/226 - (30%)

  Fly    18 DDGVLRLYSMRFCPYAQRAHLVLNAKNVPYHSVYINLTEKPEWLVEVSPLLKVPALQLVAEKGEP 82
            :||    .|:..||..||..:||..|.||:....::....|:.|.:.:|..::|.|...::
Human    14 EDG----ESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSD---- 70

  Fly    83 SLIESLIIAEYLDDKY--PENPLLP---------------------KDPLKRAQDKILLERFSSI 124
            :..::|.|.::|::..  |:.|.|.                     |:|:. |||:.|.::
Human    71 AKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVP-AQDEALYQQ---- 130

  Fly   125 TSAFINILVQGTGLEDYWTALDIFEEELTKRGTPYFGGNKPGFVDYMIWPWFERLSVIELKLQKE 189
               .:..|.:   |:.|..|  ..|.||.  |.|....::..|:|      .:||::.:..|
Human   131 ---LLRALAR---LDSYLRA--PLEHELA--GEPQLRESRRRFLD------GDRLTLADCSL--- 176

  Fly   190 YNFNESRFPKITKWIALLKADSVVQSFYATP 220
                   .||      |...|:|...|...|
Human   177 -------LPK------LHIVDTVCAHFRQAP 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstO3	NP_648234.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	3..95	CDD:469754	19/76 (25%)
		GST_C_Omega	109..230	CDD:198293	25/112 (22%)
CLIC3	NP_004660.2	Required for insertion into the membrane. /evidence=ECO:0000250	1..88		20/81 (25%)
		O-ClC	5..229	CDD:129941	50/226 (22%)
		G-site. /evidence=ECO:0000305|PubMed:28198360, ECO:0000305|PubMed:37759794	22..25		2/2 (100%)