DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex2 and pex2

DIOPT Version :9

Sequence 1:	NP_648210.1	Gene:	Pex2 / 38941	FlyBaseID:	FBgn0035876	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	XP_021325996.1	Gene:	pex2 / 556228	ZFINID:	ZDB-GENE-070530-2	Length:	312	Species:	Danio rerio

Alignment Length:	304	Identity:	96/304 - (31%)
Similarity:	143/304 - (47%)	Gaps:	61/304 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VPRVNQIDAIYLNKDIARLIRDNLLENLQAISPVLFIKIQPELDLIIQSAIWFGSVGKRCSTFGQ 71
            |.|::|:||..|:..:.:|:.....:..|...|.:...::|||..::|..:|..::....:|.||
Zfish    21 VLRISQLDAFELDGALEQLVWSQFTQCFQHFKPGILTPVEPELKALLQLLLWRFTIYSNSATVGQ 85

  Fly    72 QLLVLAYDAEKLTVSRLVLHFILTVLPGY--------VKSWEERRLTRRVEWFSEAIMWVENSAL 128
            .||.:.|..              .::||.        .|.| ...||...:||.|     .:.:|
Zfish    86 SLLNIRYKN--------------ALIPGQKYRPMSRPQKFW-FALLTVGEKWFRE-----RSHSL 130

  Fly   129 ILN-------------------------ILNYFRFLKTGRKPTLVDYLLGLDYISLRNNQRRDIG 168
            .||                         ::|:..||:.|..|||.:.|||:..:..|....|||.
Zfish   131 FLNHPAESNARKARKVLSILLGLTKAASLVNFLLFLQRGTFPTLTERLLGVQPVFSRPQGPRDIN 195

  Fly   169 YKYLTRELLWGGFMEILGLVLPIINFRKLQRVLKSWTFSGRRLEDRDGPAFLAPQMTLSTTCTFC 233
            ::||.|||||.||.|.|..:||:||..||:..: |..||  .|.|..|..  :.:.|..|.|..|
Zfish   196 FQYLNRELLWHGFAEFLIFLLPLINVWKLKAGV-SALFS--PLSDLTGTQ--SSEETHLTECAIC 255

  Fly   234 GERPTLPHHMGCGHIYCYYCLNANVLTDASFCCPNCGSACPESG 277
            ||.||:||.:||.|::||||:.:||:.|..|.||.||:   |:|
Zfish   256 GEWPTMPHSIGCKHVFCYYCVKSNVIADIYFTCPKCGA---ETG 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex2	NP_648210.1	Pex2_Pex12	22..207	CDD:282595	58/217 (27%)
Pex2	NP_648210.1	RING	230..269	CDD:214546	21/38 (55%)
pex2	XP_021325996.1	Pex2_Pex12	33..225	CDD:309754	56/211 (27%)
		RING-HC_PEX2	251..292	CDD:319440	21/40 (53%)
		RING-HC finger (C3HC4-type)	252..291	CDD:319440	21/38 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594639
Domainoid	1	1.000	75	1.000	Domainoid score	I9064
eggNOG	1	0.900	-	-		E1_KOG2879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H269
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4452
OMA	1	1.010	-	-		QHG53949
OrthoDB	1	1.010	-	-		D1494604at2759
OrthoFinder	1	1.000	-	-		FOG0005881
OrthoInspector	1	1.000	-	-		oto38631
orthoMCL	1	0.900	-	-		OOG6_103635
Panther	1	1.100	-	-	LDO	PTHR23350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5623
SonicParanoid	1	1.000	-	-		X5660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800