Protein Alignment ERR and ESRRG

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_011507567.1
• Gene: ESRRG / 2104
• HGNCID: 3474
• Length: 477
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 193/504 - (38%)
• Similarity: 254/504 - (50%)
• Gaps: 109/504 - (21%)

  Fly    46 GTNGLKSSPSVSPERQLC---------------------SSTTSLSCDLHNVSLSNDGDSLKGSG 89
            |.:||::.      |.||                     ||..||:..:::.|.....|: .||.
Human    23 GVSGLEAG------RLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDA-SGSY 80

  Fly    90 TSGGNGGGGGGGTSGGNATNASAGAGSGSVR---DEL--------------------RRLCLVCG 131
            :|..| |...|..|.....:|....|||.||   |:.                    :|||||||
Human    81 SSTMN-GHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 144

  Fly   132 DVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEG 196
            |:|||:||||||||||||||||||||||||:|||.|||||.|||||:||||||.|||.:||||||
Human   145 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEG 209

  Fly   197 VRLDRVRGGRQKY-RRNPVSNS-YQTMQLLYQSNTTSL----CDVKILEVLNSYEPDALSVQTPP 255
            ||||||||||||| ||....|| |...||:..:....|    .|.||:..|...||:.:... |.
Human   210 VRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAM-PD 273

  Fly   256 PQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWA 320
            |.|..:.|                                    :.|:.|.|:.|:|||.:||||
Human   274 PTVPDSDI------------------------------------KALTTLCDLADRELVVIIGWA 302

  Fly   321 KQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYH 385
            |.||||..|.|.|||.|||.:|.|||.|.:.:|||.|..:|.:|.|..|||..:|..|..:....
Human   303 KHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNA 367

  Fly   386 CVQIAQRMERISPRREEYYLLKALLLANCDIL-LDDQSSLRAFRDTILNSLNDVVYLLRHSSAVS 449
            .:|:.::.:.:...:||:..|||:.|||.|.: ::|..:::..:|.:..:|.|.       .|..
Human   368 ILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDY-------EAGQ 425

  Fly   450 HQQ------QLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            |.:      ::|:.||.|||......:.:..|..:..:.|.||||||||
Human   426 HMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/116 (68%)
		NR_LBD	237..493	CDD:472173	81/263 (31%)
ESRRG	XP_011507567.1	NR_DBD_ERR	134..230	CDD:143544	78/95 (82%)
		NR_LBD_ERR	256..475	CDD:132744	81/263 (31%)