Protein Alignment ERR and ESRRB

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_011534849.1
• Gene: ESRRB / 2103
• HGNCID: 3473
• Length: 573
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 197/471 - (41%)
• Similarity: 251/471 - (53%)
• Gaps: 78/471 - (16%)

  Fly    57 SPERQLCSSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATN--------ASAG 113
            |.:|.|.||..|. ......|.|:..|:|.....||.:...||.|.:.|...|        |.||
Human    24 SDDRHLGSSCGSF-IKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAG 87

  Fly   114 AG------------SGSVRDEL-----------RRLCLVCGDVASGFHYGVASCEACKAFFKRTI 155
            .|            ||.:.|..           :||||||||:|||:||||||||||||||||||
Human    88 LGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTI 152

  Fly   156 QGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYRR--NPVSNSY 218
            ||||||:|||.|||||.|||||:||||||.|||.:|||||||||||||||||||:|  :..|:.|
Human   153 QGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPY 217

  Fly   219 QTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVT 283
            .::|:   |........||:..|...|||.|....||             ....|.||
Human   218 LSLQI---SPPAKKPLTKIVSYLLVAEPDKLYAMPPP-------------GMPEGDIK------- 259

  Fly   284 PNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTL 348
                             .|:.|.|:.|:|||.:|||||.||||..|.|.|||.|||.:|.|||.|
Human   260 -----------------ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILIL 307

  Fly   349 QLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLAN 413
            .:.:||||::.||.:|.|..|||..::..|..|.|...:|:.:|.:::...:||:..||||.|||
Human   308 GIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALAN 372

  Fly   414 CD-ILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQQLLLLLPSLRQ-ADDILRRFWRGIA 476
            .| :.::|..:::..:|.:..:|.|.....||... ....:|||.||.||| |...::.|: .:.
Human   373 SDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEP-WRTGKLLLTLPLLRQTAAKAVQHFY-SVK 435

  Fly   477 RDEVITMKKLFLEMLE 492
            ....:.|.||||||||
Human   436 LQGKVPMHKLFLEMLE 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/108 (73%)
		NR_LBD	237..493	CDD:472173	91/258 (35%)
ESRRB	XP_011534849.1	NR_DBD_ERR	119..214	CDD:143544	77/94 (82%)
		NR_LBD_ERR	233..452	CDD:132744	91/258 (35%)