Protein Alignment ERR and ESRRA

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_016872802.1
• Gene: ESRRA / 2101
• HGNCID: 3471
• Length: 433
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 190/498 - (38%)
• Similarity: 253/498 - (50%)
• Gaps: 102/498 - (20%)

  Fly    16 GVSILHIKQEVDTPSASCFSP-SSKSTATQSGTNGLKSSPSVSPERQLCSSTTSLSCDLHNVSLS 79
            |:..|:||.|..:|.    || .|..|.|:.   .:..:|..:|.|          | |......
Human    17 GIEPLYIKAEPASPD----SPKGSSETETEP---PVALAPGPAPTR----------C-LPGHKEE 63

  Fly    80 NDGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGVASC 144
            .||:            |.|.|...||....:|..          :||||||||||||:|||||||
Human    64 EDGE------------GAGPGEQGGGKLVLSSLP----------KRLCLVCGDVASGYHYGVASC 106

  Fly   145 EACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKY 209
            |||||||||||||:|||:|||:|||||.||||||||||||.|||.:|||||||||||||||||||
Human   107 EACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKY 171

  Fly   210 RRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGS 274
            :|.|                    :|..|.....:....|:|...|.:  |.:..|        :
Human   172 KRRP--------------------EVDPLPFPGPFPAGPLAVAGGPRK--TAAPVN--------A 206

  Fly   275 IKLESSVVTPNGTCIFQNNNNNDPN-EILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLL 338
            :.....||.|.......:....|.: ..::.|.|::|:|:|..|.|||.||||..|.|:|||.:|
Human   207 LVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVL 271

  Fly   339 QVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEY 403
            |..|.|:|.|.:..||||...:|.||.|:.:||..|:..|..|.....:|:.:|::.:...||||
Human   272 QSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEY 336

  Fly   404 YLLKALLLANCD-ILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQ--------------- 452
            .|||||.|||.| :.::|..::...|:.:            |.:.:.::.
Human   337 VLLKALALANSDSVHIEDAEAVEQLREAL------------HEALLEYEAGRAGPGGGAERRRAG 389

  Fly   453 QLLLLLPSLRQ-ADDILRRFWRGIARDEVITMKKLFLEMLEPL 494
            :|||.||.||| |..:|..|: |:..:..:.|.||||||||.:
Human   390 RLLLTLPLLRQTAGKVLAHFY-GVKLEGKVPMHKLFLEMLEAM 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/95 (83%)
		NR_LBD	237..493	CDD:472173	85/273 (31%)
ESRRA	XP_016872802.1	NR_DBD_ERR	83..178	CDD:143544	80/124 (65%)
		NR_LBD_ERR	207..430	CDD:132744	79/235 (34%)