Protein Alignment ERR and ESR2

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001428.1
• Gene: ESR2 / 2100
• HGNCID: 3468
• Length: 530
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 157/512 - (30%)
• Similarity: 240/512 - (46%)
• Gaps: 93/512 - (18%)

  Fly    21 HIKQEVDTPSASCFSPS-------SKSTATQSGTNGLKSSPSV--------SP---ERQL----C 63
            ::....:.|:.:.:||:       |..|..:.|.....:||:|        ||   .|||    .
Human    36 YVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYA 100

  Fly    64 SSTTSLSCDLHNV--SLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRL 126
            ....|..|:..::  :|..:.::||..             .||...  ||...|.||.||  ...
Human   101 EPQKSPWCEARSLEHTLPVNRETLKRK-------------VSGNRC--ASPVTGPGSKRD--AHF 148

  Fly   127 CLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMG 191
            |.||.|.|||:||||.|||.|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:|
Human   149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVG 213

  Fly   192 MLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILE-VLNSYEPDAL---SVQ 252
            |:|.|.|  |.|.|.:..||.  .::.:.:....::..:.....::.| :|::..|:.|   .::
Human   214 MVKCGSR--RERCGYRLVRRQ--RSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLE 274

  Fly   253 TPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVI 317
            ..||.|   .|:...|..:..|:.:.                          |:.:.|||||.:|
Human   275 AEPPHV---LISRPSAPFTEASMMMS--------------------------LTKLADKELVHMI 310

  Fly   318 GWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKEC--GYT 380
            .|||:||||::|.|.||::||:..|.|:|.:.|.:||:...|||.||.|:.:|....| |  |..
Human   311 SWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGK-CVEGIL 374

  Fly   381 EFYYHCVQIAQRMERISPRREEYYLLKALLLANCDI-----LLDDQSSLRAFRDTILNSLNDVVY 440
            |.:...:....|...:..:.:||..:||::|.|..:     ...|..|.|.... :||::.|.:.
Human   375 EIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAH-LLNAVTDALV 438

  Fly   441 LLRHSSAVSHQQQ------LLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEML 491
            .:...|.:|.|||      ||:||..:|.|.:........:....|:.:..|.||||
Human   439 WVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEML 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	53/95 (56%)
		NR_LBD	237..493	CDD:472173	77/272 (28%)
ESR2	NP_001428.1	Modulating	1..148		28/128 (22%)
		ERbeta_N	16..125	CDD:463610	17/88 (19%)
		NR_DBD_ER	144..225	CDD:143545	51/84 (61%)
		NR_LBD_ER	263..498	CDD:132747	75/264 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..530