Protein Alignment ERR and nhr-3

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_510423.1
• Gene: nhr-3 / 181551
• WormBaseID: WBGene00003602
• Length: 463
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 107/459 - (23%)
• Similarity: 194/459 - (42%)
• Gaps: 116/459 - (25%)

  Fly   114 AGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKA 178
            :|...:..|...:|.||.|.|||.||||.:|..||.||:||::....|.|..:.:|.|:|..|..
 Worm    40 SGENGIDGEESTICSVCCDEASGRHYGVVACFGCKGFFRRTVRAGKNYVCRYSKKCRIDKAGRNV 104

  Fly   179 CQACRFQKCLLMGMLKEGVRLDRVRGGRQKY-RRN-----------------PVSNSYQ------ 219
            |::|||||||.:||..:.:|.||.:.||||. |||                 |..|.::
 Worm   105 CRSCRFQKCLEVGMEPDAIRPDRDKTGRQKNPRRNTEGSIKKVSVGSILGDLPCLNKFKDDSDDA 169

  Fly   220 -----------TMQL----LYQSNTTSLCDVK--ILEVLNSYEPDALSVQTPPPQVHTTSITNDE 267
                       .|.|    :.:|..|:|.:::  ::::.:::|.:.   |:.||.  ..:||...
 Worm   170 ATSPSSRADSAPMDLRPSFIDESVLTTLTEIENIVIQLQDNFETNQ---QSLPPM--GEAITKPS 229

  Fly   268 ASSSSGSIKLESSVVTPNGTCIFQNNNNN-----DPNEILSVLSDIYDKELVSVIGWAKQI--P- 324
            ..::...:....:....:..|:..|....     |....|..::|::..|.:.:   |:.|  |
 Worm   230 LIAARTLLNFNGAKGVADANCVSSNLRRMIVFTFDYINTLRPIADLHPSEKLVI---ARSIISPF 291

  Fly   325 -----GF----IDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKE---- 376
                 |:    |:.|.:|.:.|            .:...||.: :|.|..|....:::..|
 Worm   292 CILFCGYQSVAIEAPEHDSIYL------------PSGHKLPAS-QLLFTKDSDQKKYILLENKAD 343

  Fly   377 ---CGYTEFYYHCVQIAQRMERISPRREEYYLLKALL----------LANCDILLDDQSSLRAFR 428
               ...||      .|.|::.|::..:.|...|||::          ..:|::|:       ..|
 Worm   344 NVRRNMTE------MIIQQLRRLNVTKTEMVALKAIMALDHNVKGLSAESCELLV-------VAR 395

  Fly   429 DTILNSL-NDVVYLLRHSSAVSHQQQLLLLLPSLRQADDILRRFWRGIARD-----EVITMKKLF 487
            :::.|:| :.::.....:.|.|....||||:.|..:....|..|:: ::||     :.:..:.||
 Worm   396 ESVQNALFSHLIATFGTAEATSRFAHLLLLIASATRVAYSLSSFFQ-LSRDVNYEIDYVLEELLF 459

  Fly   488 LEML 491
            |:.:
 Worm   460 LDRI 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	46/113 (41%)
		NR_LBD	237..493	CDD:472173	54/295 (18%)
nhr-3	NP_510423.1	NR_DBD_HNF4A	53..128	CDD:143518	36/74 (49%)
		NR_LBD	249..432	CDD:132726	41/211 (19%)