DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ldbr and dbr1

DIOPT Version :9

Sequence 1:	NP_996022.1	Gene:	ldbr / 38900	FlyBaseID:	FBgn0035838	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_988947.1	Gene:	dbr1 / 394544	XenbaseID:	XB-GENE-5851881	Length:	534	Species:	Xenopus tropicalis

Alignment Length:	581	Identity:	254/581 - (43%)
Similarity:	332/581 - (57%)	Gaps:	97/581 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFY 65
            ||||||||.||||::||:||:.:||...||:||||||||||:.||..|::.||||:||..|.:||
Frog     1 MKIAVEGCCHGELDKIYETIQFLEKKENTKVDLLLCCGDFQAVRNEGDMKCMAVPQKYRQMQTFY 65

  Fly    66 KYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGH 130
            ||||||.:||:||||||||||||||||||||||||||||||:||||||...||||.|||||||.|
Frog    66 KYYSGEKLAPILTIFIGGNHEASNYLQELPYGGWVAPNIYYVGYAGVVKYRGVRIGGISGIFKSH 130

  Fly   131 DFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPF 195
            |:.:||.|.|||:..|.||.||||.:|||||||:...:|||:|||||..||.||||.|||:||.|
Frog   131 DYRKGHFERPPYSKDTVRSAYHVRNIEVFRLKQLKEPMDIFMSHDWPRSIYHYGNKKQLLKKKDF 195

  Fly   196 FAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDE 260
            |..::|:..|||....|||..:||:|||:||||.||||.:.|              .::.|.|
Frog   196 FRQEVENNTLGSPAASELLLHIQPSYWFSAHLHVKFAAFMQH--------------QTNVEGE-- 244

  Fly   261 EREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPR-LEYDAEWLAILHS 324
                :.||            |||||||||||.|.|||:|:|..||  |.|. ||||.||||:|.:
Frog   245 ----IPKA------------TKFLALDKCLPHREFLQIVDVEHDP--GKPDCLEYDLEWLAVLKA 291

  Fly   325 TNHLISVKENYYYLPGKKAGEFTERSNFTPTEE-ELEAVTAKFQKLQVPENFERTVPAFDPAEQS 388
            |..|:::....:.:|....  ...|.:|:.:|: :.|.:......:::|.||..|...:|| ...
Frog   292 TKDLLNITSKTWNMPENNG--LHSRWDFSASEKTKREILDDLGHDIKIPCNFCMTTACYDP-NNP 353

  Fly   389 DYK----HMFVDQPKVQLNPQSNTFCATLGIDDPLCLVL---------LANGLDLPAVGATE--- 437
            .||    |:        :|||:..|||.||:.|....:.         :....:..::|:.|
Frog   354 QYKRVATHI--------VNPQTTEFCARLGLVDLNAKIRQHEEEGDIDITEDNEADSIGSAEDPG 410

  Fly   438 --CKDRETKSSKLQ----AVEED-------VAEPLVTPTK-------------RKLNLSLPAPTT 476
              ..|....|:.:.    |:|:|       :||.|..|:.             |.|..|:...:.
Frog   411 EYSTDTSLLSTSINPDEIALEDDDDQEDEGMAEKLGEPSPDYTPDLSINFSNIRVLPDSMAVSSD 475

  Fly   477 AAADTTDENVIDLPEEEAEEAIIATETPHVEEPASVPASPNVK---KLKRRNQNIYQAQED 534
            .|.|:|::. :|..|....|.    |......|....::.|..   |:|||||.||||::|
Frog   476 DATDSTNDE-LDRSESSQTEG----EGKQSNRPLKRMSNENGSGGVKIKRRNQAIYQAKDD 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ldbr	NP_996022.1	Metallophos	1..229	CDD:278574	155/227 (68%)
		MPP_Dbr1_N	3..296	CDD:277322	175/292 (60%)
		DBR1	281..416	CDD:282819	54/140 (39%)
dbr1	NP_988947.1	MPP_Dbr1_N	3..264	CDD:277322	175/292 (60%)
		DBR1	246..379	CDD:368239	56/157 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..457		11/68 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..534		20/67 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1079
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9428
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1755
OMA	1	1.010	-	-		QHG48623
OrthoDB	1	1.010	-	-		D1047278at2759
OrthoFinder	1	1.000	-	-		FOG0004461
OrthoInspector	1	1.000	-	-		otm48894
Panther	1	1.100	-	-	LDO	PTHR12849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R294
SonicParanoid	1	1.000	-	-		X3163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110