Protein Alignment Sarm and Sarm1

DIOPT Version :10

• Sequence 1: NP_001246662.1
• Gene: Sarm / 38895
• FlyBaseID: FBgn0262579
• Length: 1730
• Species: Drosophila melanogaster
• Sequence 2: NP_001099287.1
• Gene: Sarm1 / 287545
• RGDID: 1310078
• Length: 724
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 300/682 - (43%)
• Similarity: 428/682 - (62%)
• Gaps: 18/682 - (2%)

  Fly   671 GSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWAVPTHG 735
            |.|.:|:...:.  :.:..::..||.|.::..|.:............|.::.:::..||.:|..|
  Rat    47 GRGSREVSPGVG--TEVQGALERSLPELQQALSELKQASAAQAVGAGLAEVFQLVEEAWLLPAVG 109

  Fly   736 HELGYSLCNSLRQSGGLDLLMKNCVKPDLQ--FSSAQLLEQCLTTENRKHVVDNGLDKVVNVACV 798
            .|:...||:::|..||||||::....|:|:  ..:|:||||.|..|||..|...||..::|::
  Rat   110 REVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLS-- 172

  Fly   799 CTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLY 863
             .:...:|.:|...|||||:|||||.||..::..|||||||:.||.:|...|||||.||||.:|:
  Rat   173 -KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALH 236

  Fly   864 GGAENQEEMILRKVPMWLFPLAFHNDDN-IKYYACLAIAVLVANKEIEAEVLKSGCLDLVEPFVT 927
            ||...|..|:.::...|||||||..:|. ::.:||||:|||..|||:|.||..||.|.||||.|.
  Rat   237 GGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVA 301

  Fly   928 SHDPSAFAR-----SNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQGNTDI 987
            |.||..|||     |:.:...|...  |:.||.:|.|:|.||:.:.||:.|.||.||..||.|.:
  Rat   302 SLDPGRFARCLVDASDTSQGRGPDD--LQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKV 364

  Fly   988 FREINAIEALKNVAS-CPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQIGFNDY 1051
            |.:|.||::||.:.| ..|...|..|.:||||:||.||.::...|..|...:||.|::||||:.|
  Rat   365 FSDIGAIQSLKRLVSYSTNGTTSTLAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQY 429

  Fly  1052 IDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQFLSEI 1116
            .:.|.:.||||||||:|..:.|:.|:|:.:.|..|||.|||..||..|.|::.|.:.:..:|..:
  Rat   430 CENFRDQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSL 494

  Fly  1117 GTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKN-LENSLPSSSEENMA 1180
            ...:..|||.:::.|:|:..|..|:|..|:.:|||...:||.|||:|.:. |.:.||.:..:...
  Rat   495 DPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKPSG 559

  Fly  1181 KTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPD 1245
            .|.|||:||||::||||||||||||||.|||||||||:||||||::.|:.|:..|:||||||:..
  Rat   560 DTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMAARNFVLVLSAG 624

  Fly  1246 ALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQ 1310
            ||.:|:.|.:||||||:|||.||:.:.||:|||| .|:|||.:.|||||::|..|||:.|.|:||
  Rat   625 ALDKCMQDHECKDWVHKEIVTALSCSKNIVPIID-GFEWPEPQALPEDMQAVLTFNGIKWSHEYQ 688

  Fly  1311 DACIDKLERFLRGEKNIDRIAAMVPGTPGSVS 1342
            :|.|:|:.|||:|..:.|..|.......|:.|
  Rat   689 EATIEKIIRFLQGRPSQDSSAGSDTSLEGATS 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sarm	NP_001246662.1	SARM1_N	716..1021	CDD:467946	137/313 (44%)
		SAM_SARM1-like_repeat1	1031..1099	CDD:188900	32/67 (48%)
		SAM_SARM1-like_repeat2	1100..1169	CDD:188901	22/69 (32%)
		TIR	1184..1321	CDD:214587	87/136 (64%)
Sarm1	NP_001099287.1	SAM_SARM1-like_repeat2	479..547	CDD:188901	21/67 (31%)
		TIR	561..702	CDD:214587	90/141 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	703..724		4/18 (22%)
		ARM 1. /evidence=ECO:0000255	60..100		5/39 (13%)
		SARM1_N	88..399	CDD:467946	137/315 (43%)
		ARM 2. /evidence=ECO:0000255	114..153		16/38 (42%)
		ARM 3. /evidence=ECO:0000255	155..193		14/40 (35%)
		ARM 4. /evidence=ECO:0000255	196..235		22/38 (58%)
		ARM 5. /evidence=ECO:0000255	237..280		19/42 (45%)
		ARM 6. /evidence=ECO:0000255	281..314		19/32 (59%)
		ARM 7. /evidence=ECO:0000255	315..354		14/40 (35%)
		ARM 8. /evidence=ECO:0000255	359..402		19/42 (45%)
		SAM_SARM1-like_repeat1	409..477	CDD:188900	32/67 (48%)