Protein Alignment Sarm and tir-1

DIOPT Version :10

• Sequence 1: NP_001246662.1
• Gene: Sarm / 38895
• FlyBaseID: FBgn0262579
• Length: 1730
• Species: Drosophila melanogaster
• Sequence 2: NP_001299866.1
• Gene: tir-1 / 175502
• WormBaseID: WBGene00006575
• Length: 984
• Species: Caenorhabditis elegans
• Alignment Length: 909
• Identity: 325/909 - (35%)
• Similarity: 505/909 - (55%)
• Gaps: 78/909 - (8%)

  Fly   512 SEQATSNSAEMKRLQAGDIDYQESKGASAMRNRLEVDGVKTEENAAVIKEALSLRTGDITQQASN 576
            ||.|..:......|.. |.|::|.:....|..:.|.||..|..:.|..:      ..|....:|.
 Worm    43 SEDAKDDDLITPELST-DFDFREIQHRYLMALQNEQDGETTSTDDAFFE------LDDDDDLSSP 100

  Fly   577 NVAASSITVQSENFSADKKA----------ISQSQQSQTMTSNGI-ISQEKHVSSASQANYSMSH 630
            :|..|.:...|.:.....|:          ::......|:.|||. |...:...:.|..:.|:.|
 Worm   101 SVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIH 165

  Fly   631 KGVSSTGSSMITSSSQMSAMNGQMLKLADLKLDDLKSLTAGSGQQEIEQT-------INKYSNML 688
            :.......|...:.|:....|||:.|.::.:....:..|||:.....|:|       :::.|...
 Worm   166 EARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSG 230

  Fly   689 T--------SIVSSLQEDERGGSAITVHDVGGKKSQY---LEK-------------------INE 723
            |        |:|:...:.........:|.:..|.|:|   ::|                   :.:
 Worm   231 TARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRK 295

  Fly   724 VIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPD------LQFSSAQLLEQCLTTENRK 782
            ::|:.|..|....:|..:||:.||.....|.|:|..:.|:      ::....::||:|.::.|.:
 Worm   296 LMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLE 360

  Fly   783 HVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLF------E 841
            ::|:....|.:.:..: ..|...:..|:...::.:|||||......:|....:|.::.      |
 Worm   361 YIVNKSYTKKIMIVAM-KLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPE 424

  Fly   842 CRTSDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVAN 906
            |.    :.|||.|.||||:.||...|.::::|.:|:|.|||.||...||..:||||:|:..:|:.
 Worm   425 CP----DILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSV 485

  Fly   907 KEIEAEVLKSGCLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLS-SNREEARNLAAF 970
            ||.|..|.||..:.|||||:..|||:.|||....:|.|.:|.||:||:|:|. |.|.|||::|||
 Worm   486 KEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAF 550

  Fly   971 HFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQALRLIGETVPHKLSQQVPLWS 1035
            ||.:||.||:||...|:|:||.||:|||.|||.|:.:|:|||::||.:|||.||:||:||||.|:
 Worm   551 HFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWT 615

  Fly  1036 VEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMAD 1100
            ..|||.|||:|||.:|::||.:..|||||||:|.:::|:.|:|:.:|:..|||.||||.||..||
 Worm   616 CADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAAD 680

  Fly  1101 YSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVK 1165
            |||.|.:.:..||..:..:...|||.||..|:::..|..:.::|:...|||.|.||||::..|.:
 Worm   681 YSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFE 745

  Fly  1166 NLENSLPSSSEENM-AKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLL 1229
            ..::  |...|..| :|.:|||:|||||.|:|||||:||.|||||:.|||||::|.|||||:.||
 Worm   746 TAKH--PDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLL 808

  Fly  1230 NSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVE-RLPED 1293
            .:|:.||:|:|||||::|.|.:||::|:||||:|:..|.....|||||.|..|::|..| ::|.|
 Worm   809 KNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPND 873

  Fly  1294 MRSVAHFNGVNWIHDYQDACIDKLERFLRGEKN-IDRIAAMVPGTPGSVSYQRMHSNDSDYQSG 1356
            :|.:..:|||.|:|||||||:.|:.||:.||.| .......:|......:.||..:.::..::|
 Worm   874 IRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTG 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sarm	NP_001246662.1	SARM1_N	716..1021	CDD:467946	120/339 (35%)
		SAM_SARM1-like_repeat1	1031..1099	CDD:188900	36/67 (54%)
		SAM_SARM1-like_repeat2	1100..1169	CDD:188901	24/68 (35%)
		TIR	1184..1321	CDD:214587	79/137 (58%)
tir-1	NP_001299866.1	SARM1_N	286..601	CDD:467946	118/319 (37%)
		SAM_SARM1-like_repeat1	611..679	CDD:188900	36/67 (54%)
		SAM_SARM1-like_repeat2	680..749	CDD:188901	24/68 (35%)
		TIR	761..904	CDD:214587	80/142 (56%)