Protein Alignment CG7457 and SLF1

DIOPT Version :10

• Sequence 1: NP_648150.1
• Gene: CG7457 / 38865
• FlyBaseID: FBgn0035812
• Length: 1405
• Species: Drosophila melanogaster
• Sequence 2: NP_115666.2
• Gene: SLF1 / 84250
• HGNCID: 25408
• Length: 1058
• Species: Homo sapiens
• Alignment Length: 944
• Identity: 195/944 - (20%)
• Similarity: 341/944 - (36%)
• Gaps: 305/944 - (32%)

  Fly     2 EEKRYLKRKEK--ARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAK 64
            |.::.:|:|::  .||...|.:            .::||.::. ::.|:..:|.:::.:.:....
Human   292 ENQKEIKKKDEDIQRSYTLRRK------------RKKGKESNC-KKGVEHEKIKSTLRRHIYNRD 343

  Fly    65 AKRMVGEMYTLLCDYDAAKDHINDYLKIAK--RLKNQVEEQRAYATLGRVHLLHGQSL------A 121
            .|.|...::.             :|.|.:|  .:|..|:......|| |.|:...|::      .
Human   344 QKEMKNSIFA-------------EYAKESKAMAIKTDVDVVEIKNTL-RKHIYRAQAVRYNCIRI 394

  Fly   122 DSSASGSMEQLKLAE-----KNFLRSLL---LIKDLSGQISKLEQLDMQARCYLNI---GVVKEH 175
            |.....::| :|.||     .|.:.||:   ..|:...::|.|:...:...|.|:.   .|::::
Human   395 DKQPVYNVE-VKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDN 458

  Fly   176 MEAFQESIEYIDKAI----------KISKTH-EL----------WDLTHLCYISMSLLYICKKND 219
            ::.|.....:|..|:          .:|:.: ||          |.|..:      |:..|..|:
Human   459 IDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEV------LIRSCLFNE 517

  Fly   220 ATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGDFASAKQILTKAYKKNTPDENDRVN 284
            :     ||:   ::::...:||..:  ||:.....||:    :..:.:..|.|     |.:|..|
Human   518 S-----FCH---QISENIGSKVLHL--TLLKFFFNLIE----SEVQHLSQKLY-----DWSDSQN 563

  Fly   285 IE---KQLRIVVKVCQTLDELVLTSSVDYAKLKGLYE-----KLGDGCCHLMNY------EKALT 335
            ::   |.:.:.:....:....:||..|:......:|.     |..|...|.:.|      ..|:.
Human   564 LKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAID 628

  Fly   336 YY----QKMLENA--ELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFEL----NQDAPS 390
            |:    .||..|.  .::.:.|.     ||||           ...::..:|.|:    ...:..
Human   629 YWIFLGLKMGRNVMRHMSDDLGS-----YVSL-----------SCDDFSSQELEIFICSFSSSWL 677

  Fly   391 EAFTTLCTIAEICEQ-----QSHPFWTVHDVYQ--KALRQADKAGS----CSDKLVKIAMVRLRR 444
            :.|.......::|.|     .|.|......||.  .||.:....||    .|.|:.:......:|
Human   678 QMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQR 742

  Fly   445 --LMLKHNMQVLVENLEADATAKGIDLDQ---EESVGDDEEESDGGGTAVQQNTPDWDDDFDLAT 504
              |||....|..||.|     .:.:||:.   ..|:...:::|:|..:..::|.|.
Human   743 TLLMLNGTKQKQVEGL-----PELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPS--------- 793

  Fly   505 LTDSDASDLDETEKPRPQRTTRGNRTLVIKKNN------KGETQLHQACISGNLE-LVRRLIDQG 562
                                       |:||.|      ||||.||:|||:..:| |:..|...|
Human   794 ---------------------------VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPG 831

  Fly   563 HTVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAE 627
            ..:||:|:|||.|||||||:|....|:.:|.:.....:.    |..||:|||.||.|||.:::.:
Human   832 IDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLL----TQVDGVTPLHDALSNGHVEIGK 892

  Fly   628 LLLDRGADATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPL 692
            |||..|                      |..|:....|                     |...||
Human   893 LLLQHG----------------------GPVLLQQRNA---------------------KGELPL 914

  Fly   693 TNFNAKRISREERGSMSEEEDEEEALHESNRRSLSHNRSGSEYGAKK------------SKSSTQ 745
            ....:.:| :||..::::.||..|..|....:...:.:  .|:|:..            ..||..
Human   915 DYVVSPQI-KEELFAITKIEDTVENFHAQAEKHFHYQQ--LEFGSFLLSRMLLNFCSIFDLSSEF 976

  Fly   746 PSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKRKRINS 810
            ..|||.    :.||   |.|      ......||....:..|      ||:|          :.:
Human   977 ILASKG----LTHL---NEL------LMACKSHKETTSVHTD------WLLD----------LYA 1012

  Fly   811 GDLSRRTSKENFQDTALSLPANWEDDLLQATPEN 844
            |::.          |...||     .:|:..|||
Human  1013 GNIK----------TLQKLP-----HILKELPEN 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_648150.1	LapB	28..385	CDD:442196	75/420 (18%)
		TPR repeat	163..191	CDD:276809	6/40 (15%)
		TPR repeat	196..233	CDD:276809	9/47 (19%)
		TPR repeat	238..273	CDD:276809	7/34 (21%)
		TPR repeat	316..342	CDD:276809	9/40 (23%)
		TPR repeat	347..384	CDD:276809	6/36 (17%)
		TPR repeat	389..422	CDD:276809	8/39 (21%)
		ANKYR	<532..>645	CDD:440430	48/119 (40%)
		ANK repeat	539..569	CDD:293786	14/30 (47%)
		ANK repeat	571..604	CDD:293786	13/32 (41%)
		ANK repeat	609..639	CDD:293786	14/29 (48%)
		RNA1	<1038..1233	CDD:444072
		leucine-rich repeat	1088..1115	CDD:275381
		leucine-rich repeat	1116..1170	CDD:275381
		leucine-rich repeat	1199..1225	CDD:275381
		leucine-rich repeat	1226..1261	CDD:275381
		leucine-rich repeat	1262..1289	CDD:275381
		leucine-rich repeat	1290..1315	CDD:275381
SLF1	NP_115666.2	BRCT_SLF1	5..85	CDD:349381
		BRCT	127..198	CDD:469589
		NSE5-like domain, mediates interaction with SLF2. /evidence=ECO:0000269|PubMed:36373674	410..1058		168/798 (21%)
		ANKYR	<796..>916	CDD:440430	53/166 (32%)
		ANK repeat	807..838	CDD:293786	14/30 (47%)
		ANK repeat	840..871	CDD:293786	13/34 (38%)
		ANK repeat	874..904	CDD:293786	16/51 (31%)