DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7457 and SLF1

DIOPT Version :9

Sequence 1:NP_648150.1 Gene:CG7457 / 38865 FlyBaseID:FBgn0035812 Length:1405 Species:Drosophila melanogaster
Sequence 2:NP_115666.2 Gene:SLF1 / 84250 HGNCID:25408 Length:1058 Species:Homo sapiens


Alignment Length:944 Identity:195/944 - (20%)
Similarity:341/944 - (36%) Gaps:305/944 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EEKRYLKRKEK--ARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAK 64
            |.::.:|:|::  .||...|.:            .::||.::. ::.|:..:|.:::.:.:....
Human   292 ENQKEIKKKDEDIQRSYTLRRK------------RKKGKESNC-KKGVEHEKIKSTLRRHIYNRD 343

  Fly    65 AKRMVGEMYTLLCDYDAAKDHINDYLKIAK--RLKNQVEEQRAYATLGRVHLLHGQSL------A 121
            .|.|...::.             :|.|.:|  .:|..|:......|| |.|:...|::      .
Human   344 QKEMKNSIFA-------------EYAKESKAMAIKTDVDVVEIKNTL-RKHIYRAQAVRYNCIRI 394

  Fly   122 DSSASGSMEQLKLAE-----KNFLRSLL---LIKDLSGQISKLEQLDMQARCYLNI---GVVKEH 175
            |.....::| :|.||     .|.:.||:   ..|:...::|.|:...:...|.|:.   .|::::
Human   395 DKQPVYNVE-VKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDN 458

  Fly   176 MEAFQESIEYIDKAI----------KISKTH-EL----------WDLTHLCYISMSLLYICKKND 219
            ::.|.....:|..|:          .:|:.: ||          |.|..:      |:..|..|:
Human   459 IDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEV------LIRSCLFNE 517

  Fly   220 ATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGDFASAKQILTKAYKKNTPDENDRVN 284
            :     ||:   ::::...:||..:  ||:.....||:    :..:.:..|.|     |.:|..|
Human   518 S-----FCH---QISENIGSKVLHL--TLLKFFFNLIE----SEVQHLSQKLY-----DWSDSQN 563

  Fly   285 IE---KQLRIVVKVCQTLDELVLTSSVDYAKLKGLYE-----KLGDGCCHLMNY------EKALT 335
            ::   |.:.:.:....:....:||..|:......:|.     |..|...|.:.|      ..|:.
Human   564 LKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAID 628

  Fly   336 YY----QKMLENA--ELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFEL----NQDAPS 390
            |:    .||..|.  .::.:.|.     ||||           ...::..:|.|:    ...:..
Human   629 YWIFLGLKMGRNVMRHMSDDLGS-----YVSL-----------SCDDFSSQELEIFICSFSSSWL 677

  Fly   391 EAFTTLCTIAEICEQ-----QSHPFWTVHDVYQ--KALRQADKAGS----CSDKLVKIAMVRLRR 444
            :.|.......::|.|     .|.|......||.  .||.:....||    .|.|:.:......:|
Human   678 QMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQR 742

  Fly   445 --LMLKHNMQVLVENLEADATAKGIDLDQ---EESVGDDEEESDGGGTAVQQNTPDWDDDFDLAT 504
              |||....|..||.|     .:.:||:.   ..|:...:::|:|..:..::|.|.         
Human   743 TLLMLNGTKQKQVEGL-----PELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPS--------- 793

  Fly   505 LTDSDASDLDETEKPRPQRTTRGNRTLVIKKNN------KGETQLHQACISGNLE-LVRRLIDQG 562
                                       |:||.|      ||||.||:|||:..:| |:..|...|
Human   794 ---------------------------VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPG 831

  Fly   563 HTVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAE 627
            ..:||:|:|||.|||||||:|....|:.:|.:.....:.    |..||:|||.||.|||.:::.:
Human   832 IDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLL----TQVDGVTPLHDALSNGHVEIGK 892

  Fly   628 LLLDRGADATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPL 692
            |||..|                      |..|:....|                     |...||
Human   893 LLLQHG----------------------GPVLLQQRNA---------------------KGELPL 914

  Fly   693 TNFNAKRISREERGSMSEEEDEEEALHESNRRSLSHNRSGSEYGAKK------------SKSSTQ 745
            ....:.:| :||..::::.||..|..|....:...:.:  .|:|:..            ..||..
Human   915 DYVVSPQI-KEELFAITKIEDTVENFHAQAEKHFHYQQ--LEFGSFLLSRMLLNFCSIFDLSSEF 976

  Fly   746 PSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKRKRINS 810
            ..|||.    :.||   |.|      ......||....:..|      ||:|          :.:
Human   977 ILASKG----LTHL---NEL------LMACKSHKETTSVHTD------WLLD----------LYA 1012

  Fly   811 GDLSRRTSKENFQDTALSLPANWEDDLLQATPEN 844
            |::.          |...||     .:|:..|||
Human  1013 GNIK----------TLQKLP-----HILKELPEN 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7457NP_648150.1 LapB 28..385 CDD:442196 75/420 (18%)
TPR repeat 163..191 CDD:276809 6/40 (15%)
TPR repeat 196..233 CDD:276809 9/47 (19%)
TPR repeat 238..273 CDD:276809 7/34 (21%)
TPR repeat 316..342 CDD:276809 9/40 (23%)
TPR repeat 347..384 CDD:276809 6/36 (17%)
TPR repeat 389..422 CDD:276809 8/39 (21%)
ANKYR <532..>645 CDD:440430 48/119 (40%)
ANK repeat 539..569 CDD:293786 14/30 (47%)
ANK repeat 571..604 CDD:293786 13/32 (41%)
ANK repeat 609..639 CDD:293786 14/29 (48%)
RNA1 <1038..1233 CDD:444072
leucine-rich repeat 1088..1115 CDD:275381
leucine-rich repeat 1116..1170 CDD:275381
leucine-rich repeat 1199..1225 CDD:275381
leucine-rich repeat 1226..1261 CDD:275381
leucine-rich repeat 1262..1289 CDD:275381
leucine-rich repeat 1290..1315 CDD:275381
SLF1NP_115666.2 BRCT_SLF1 5..85 CDD:349381
BRCT 127..198 CDD:469589
NSE5-like domain, mediates interaction with SLF2. /evidence=ECO:0000269|PubMed:36373674 410..1058 168/798 (21%)
ANKYR <796..>916 CDD:440430 53/166 (32%)
ANK repeat 807..838 CDD:293786 14/30 (47%)
ANK repeat 840..871 CDD:293786 13/34 (38%)
ANK repeat 874..904 CDD:293786 16/51 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.