DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7457 and SLF1

DIOPT Version :9

Sequence 1:	NP_001303376.1	Gene:	CG7457 / 38865	FlyBaseID:	FBgn0035812	Length:	1405	Species:	Drosophila melanogaster
Sequence 2:	NP_115666.2	Gene:	SLF1 / 84250	HGNCID:	25408	Length:	1058	Species:	Homo sapiens

Alignment Length:	944	Identity:	195/944 - (20%)
Similarity:	341/944 - (36%)	Gaps:	305/944 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEKRYLKRKEK--ARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAK 64
            |.::.:|:|::  .||...|.:            .::||.::. ::.|:..:|.:::.:.:....
Human   292 ENQKEIKKKDEDIQRSYTLRRK------------RKKGKESNC-KKGVEHEKIKSTLRRHIYNRD 343

  Fly    65 AKRMVGEMYTLLCDYDAAKDHINDYLKIAK--RLKNQVEEQRAYATLGRVHLLHGQSL------A 121
            .|.|...::.             :|.|.:|  .:|..|:......|| |.|:...|::      .
Human   344 QKEMKNSIFA-------------EYAKESKAMAIKTDVDVVEIKNTL-RKHIYRAQAVRYNCIRI 394

  Fly   122 DSSASGSMEQLKLAE-----KNFLRSLL---LIKDLSGQISKLEQLDMQARCYLNI---GVVKEH 175
            |.....::| :|.||     .|.:.||:   ..|:...::|.|:...:...|.|:.   .|::::
Human   395 DKQPVYNVE-VKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDN 458

  Fly   176 MEAFQESIEYIDKAI----------KISKTH-EL----------WDLTHLCYISMSLLYICKKND 219
            ::.|.....:|..|:          .:|:.: ||          |.|..:      |:..|..|:
Human   459 IDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEV------LIRSCLFNE 517

  Fly   220 ATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGDFASAKQILTKAYKKNTPDENDRVN 284
            :     ||:   ::::...:||..:  ||:.....||:    :..:.:..|.|     |.:|..|
Human   518 S-----FCH---QISENIGSKVLHL--TLLKFFFNLIE----SEVQHLSQKLY-----DWSDSQN 563

  Fly   285 IE---KQLRIVVKVCQTLDELVLTSSVDYAKLKGLYE-----KLGDGCCHLMNY------EKALT 335
            ::   |.:.:.:....:....:||..|:......:|.     |..|...|.:.|      ..|:.
Human   564 LKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAID 628

  Fly   336 YY----QKMLENA--ELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFEL----NQDAPS 390
            |:    .||..|.  .::.:.|.     ||||           ...::..:|.|:    ...:..
Human   629 YWIFLGLKMGRNVMRHMSDDLGS-----YVSL-----------SCDDFSSQELEIFICSFSSSWL 677

  Fly   391 EAFTTLCTIAEICEQ-----QSHPFWTVHDVYQ--KALRQADKAGS----CSDKLVKIAMVRLRR 444
            :.|.......::|.|     .|.|......||.  .||.:....||    .|.|:.:......:|
Human   678 QMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQR 742

  Fly   445 --LMLKHNMQVLVENLEADATAKGIDLDQ---EESVGDDEEESDGGGTAVQQNTPDWDDDFDLAT 504
              |||....|..||.|     .:.:||:.   ..|:...:::|:|..:..::|.|.
Human   743 TLLMLNGTKQKQVEGL-----PELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPS--------- 793

  Fly   505 LTDSDASDLDETEKPRPQRTTRGNRTLVIKKNN------KGETQLHQACISGNLE-LVRRLIDQG 562
                                       |:||.|      ||||.||:|||:..:| |:..|...|
Human   794 ---------------------------VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPG 831

  Fly   563 HTVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAE 627
            ..:||:|:|||.|||||||:|....|:.:|.:.....:.    |..||:|||.||.|||.:::.:
Human   832 IDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLL----TQVDGVTPLHDALSNGHVEIGK 892

  Fly   628 LLLDRGADATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPL 692
            |||..|                      |..|:....|                     |...||
Human   893 LLLQHG----------------------GPVLLQQRNA---------------------KGELPL 914

  Fly   693 TNFNAKRISREERGSMSEEEDEEEALHESNRRSLSHNRSGSEYGAKK------------SKSSTQ 745
            ....:.:| :||..::::.||..|..|....:...:.:  .|:|:..            ..||..
Human   915 DYVVSPQI-KEELFAITKIEDTVENFHAQAEKHFHYQQ--LEFGSFLLSRMLLNFCSIFDLSSEF 976

  Fly   746 PSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKRKRINS 810
            ..|||.    :.||   |.|      ......||....:..|      ||:|          :.:
Human   977 ILASKG----LTHL---NEL------LMACKSHKETTSVHTD------WLLD----------LYA 1012

  Fly   811 GDLSRRTSKENFQDTALSLPANWEDDLLQATPEN 844
            |::.          |...||     .:|:..|||
Human  1013 GNIK----------TLQKLP-----HILKELPEN 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_001303376.1	TPR_12	21..95	CDD:290160	9/75 (12%)
		TPR	68..387	CDD:223533	70/382 (18%)
		TPR repeat	163..191	CDD:276809	6/40 (15%)
		TPR repeat	196..233	CDD:276809	9/47 (19%)
		TPR repeat	238..273	CDD:276809	7/34 (21%)
		TPR repeat	316..342	CDD:276809	9/40 (23%)
		TPR repeat	347..384	CDD:276809	6/36 (17%)
		TPR repeat	389..422	CDD:276809	8/39 (21%)
		ANK	535..647	CDD:238125	46/118 (39%)
		ANK repeat	539..569	CDD:293786	14/30 (47%)
		Ank_2	543..639	CDD:289560	40/96 (42%)
		ANK repeat	571..604	CDD:293786	13/32 (41%)
		ANK repeat	609..639	CDD:293786	14/29 (48%)
		LRR_RI	1063..1360	CDD:238064
		leucine-rich repeat	1088..1115	CDD:275381
		leucine-rich repeat	1116..1170	CDD:275381
		leucine-rich repeat	1199..1225	CDD:275381
		leucine-rich repeat	1226..1261	CDD:275381
		leucine-rich repeat	1262..1289	CDD:275381
		leucine-rich repeat	1290..1315	CDD:275381
SLF1	NP_115666.2	BRCT	<12..88	CDD:320726
		ANK	803..918	CDD:238125	50/161 (31%)
		ANK 1	806..836		13/29 (45%)
		ANK repeat	807..838	CDD:293786	14/30 (47%)
		ANK repeat	840..871	CDD:293786	13/34 (38%)
		ANK 2	840..869		13/28 (46%)
		ANK repeat	874..904	CDD:293786	16/51 (31%)
		ANK 3	874..903		15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030