Protein Alignment Mitf and TFEB

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 180/664 - (27%)
• Similarity: 251/664 - (37%)
• Gaps: 214/664 - (32%)

  Fly   166 SGGPTFKTATPTSRTQLKLQLQREQQQQ----MMIQQQTLDTAMDPKMHLLFGSGQGLMESEFID 226
            ||......||..||..|::||.|||.||    ..:|||.:       ||.:
Human     5 SGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAV-------MHYM-------------- 48

  Fly   227 SGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGA-KLKVPLQSIGVDVPPQVLQVSTVLENPTRYH 290
                           |..|..|...|....:.| ...|..|| ...||.:||:|.:.|||||.||
Human    49 ---------------QQQQQQQQQQLGGPPTPAINTPVHFQS-PPPVPGEVLKVQSYLENPTSYH 97

  Fly   291 VIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSA 355
            :.|.|..:||:||||::                                       .|:|
Human    98 LQQSQHQKVREYLSETY---------------------------------------GNKF----- 118

  Fly   356 VSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNS-----HGAGEPENAHRTAQLGLSKA 415
              |..|.|:..:....|.....||...:.........|||     |....||.........:.:.
Human   119 --AAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRL 181

  Fly   416 NSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKN 480
            :..|........:.|::.:||:..::.|:...::.|:..| ||.|.|.|
Human   182 DDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGV-TSSSCPAD---------------- 229

  Fly   481 FNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVV 545
                |:.|:|   |||||..||||:||||||||:|||||||||||||||||.|:||.:|.
Human   230 ----LTQKRE---LTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDL----- 282

  Fly   546 RDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSE 610
             |:|.|||||||:|||||:.::.::.:.|:.|...|::|:.|::|..||:||||||:.||:
Human   283 -DVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGL---- 342

  Fly   611 NHLTSLSAPTQPYLKSFSLSPTASRS---RRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCK 672
                                ||.|.|   ...|..|.|::::...:|..            |...
Human   343 --------------------PTTSPSGMNMAELAQQVVKQELPSEEGPG------------EALM 375

  Fly   673 YAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCGINCSTS 737
            ...:..||        :..|..|....|...:..|..|...|.|
Human   376 LGAEVPDP--------EPLPALPPQAPLPLPTQPPSPFHHLDFS--------------------- 411

  Fly   738 CYIQHQLT----SREGHPNH------SHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLS------ 786
                |.|:    ..||.|.:      .|.:....:..........:.|.|....|||||
Human   412 ----HSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEA 472

  Fly   787 ---SSHRSLGTVDE 797
               ||.||..:::|
Human   473 SKASSRRSSFSMEE 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	20/38 (53%)
		bHLHzip_MITF_like	504..577	CDD:381403	45/72 (63%)
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..176	CDD:464952	56/240 (23%)
		bHLHzip_TFEB	240..330	CDD:381497	54/95 (57%)
		DUF3371	335..487	CDD:463372	41/221 (19%)