Protein Alignment Mitf and tfeb

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_031752001.1
• Gene: tfeb / 780105
• XenbaseID: XB-GENE-982675
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 632
• Identity: 175/632 - (27%)
• Similarity: 260/632 - (41%)
• Gaps: 199/632 - (31%)

  Fly   112 DCDCV---PLCMTNIRVSVGIDKDLEMILEMDPSIVDLGDISIDETAEPRIVGLPPLSGGPTFKT 173
            ||.|.   |.|....::.         ::::..|:|                 |||:.
 Frog    12 DCGCELQHPCCFAAAQLP---------LVDVVSSLV-----------------LPPIM------- 43

  Fly   174 ATPTSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSS 238
               .||..|::||.|||.||   ::|........:.|.|
 Frog    44 ---ASRIGLRMQLMREQAQQ---EEQRERVQQQHQQHFL-------------------------- 76

  Fly   239 SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYL 303
               |...:|.:......|:.|..:.|     ..||.:||:|.|.|||||.||:.|.:..:||.||
 Frog    77 ---QQHHIVPVTASPAISTPASFQAP-----PPVPVEVLEVQTHLENPTIYHLQQSRDKKVRDYL 133

  Fly   304 SESFKPSMWGSHTSEIKL---------------ANNSASTGN-LQNSSLQK-GICDPLERTNRFG 351
            |::: .:.:.:|.:.::|               |..|:|.|| ..||.:.: .:|..:|
 Frog   134 SDTY-GNKFAAHLNPLRLSPKPPPAPASPAHRAARLSSSAGNSAPNSPMARMNLCSNVE------ 191

  Fly   352 CDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKAN 416
            .|..:.  .||..||.     ||..          ||.:..||:              |..|.::
 Frog   192 MDDVID--NIMSLDDM-----FGYP----------EPAISMPNT--------------LPFSSSH 225

  Fly   417 SSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNF 481
            ..|.|        ::.|:|.|...:.|.|.|
 Frog   226 LGLYS--------DNPRLSDTVVGVTSNSCP---------------------------------- 248

  Fly   482 NSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVR 546
             ::|:||:|   |||||..||.::|||||.||||||||||||||||||||||:||.::     :.
 Frog   249 -ADLAIKRE---LTDAENRALVRERQKKDTHNMIERRRRFNINDRIKELGTLIPKTNE-----LS 304

  Fly   547 DIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSEN 611
            |.|.||||||::||||||.::.|..:.|:.|...||:||.|::|:.||:|||.||:.||:..|..
 Frog   305 DTRWNKGTILRASVDYIKHMQKEQQKSRELETHSRQLELANKQLLLRIQELERQAQMHGLPASSP 369

  Fly   612 HLTSLSAPTQPYLKSFSL----SPTASRSRRSL-FDQPVEKKIQ---VIDGADGNMGMNQVD-EF 667
            |  .||.......:|.|:    ....:.|:.|. .|.|.....|   .:|.:..::...::| ..
 Frog   370 H--GLSPADHMKQESNSIPSIQQQLVATSQASFQMDYPAPLGYQSNTSVDTSFPSLSRTELDLML 432

  Fly   668 MEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEAD 714
            |||   .:...||:::....|.:.....|..:....||   :..|.|
 Frog   433 MED---TMLTSDPLMACDPVMSTLSPDTSKASSRRSSF---SIDEVD 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	19/38 (50%)
		bHLHzip_MITF_like	504..577	CDD:381403	45/72 (63%)
tfeb	XP_031752001.1	MITF_TFEB_C_3_N	46..197	CDD:464952	48/194 (25%)
		bHLHzip_TFEB	261..352	CDD:381497	55/95 (58%)
		DUF3371	357..471	CDD:463372	26/121 (21%)