Protein Alignment Mitf and TFE3

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 212/787 - (26%)
• Similarity: 302/787 - (38%)
• Gaps: 265/787 - (33%)

  Fly    64 MSH--NESRDLVNGPNICSSMDIEVGEEPPTTSFADNIDKACPLPVLRSSDCDCVPLCMTNIRVS 126
            |||  ..:||           .:|...|.|...|.       .|...|.:| ....|.:.::...
Human     1 MSHAAEPARD-----------GVEASAEGPRAVFV-------LLEERRPAD-SAQLLSLNSLLPE 46

  Fly   127 VGIDKDLEMILEMDP-SIVDLGD----------ISIDET-AEPRIVGLPPLSGG---PTFKTATP 176
            .||..|:|:...:|| |..:|..          ||:..| |.|..:.....:||   |...:::
Human    47 SGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSS- 110

  Fly   177 TSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLE 241
            :||..|:.||.|.|.|:...:::....|..|            ..|....|.:.|..|.
Human   111 SSRVLLRQQLMRAQAQEQERRERREQAAAAP------------FPSPAPASPAISVVGV------ 157

  Fly   242 QMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSES 306
                         |:.|..|..|..:   .||.:||:|.|.||||||||:.|.::.||:||||.:
Human   158 -------------SAGGHTLSRPPPA---QVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTT 206

  Fly   307 FKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPIS 371
            ..|          |||:.:                                            ::
Human   207 LGP----------KLASQA--------------------------------------------LT 217

  Fly   372 PFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSL-------SSTRSSSGIV 429
            |            |..|...:|    ...||.||.|...| |..||.:       ||.:....::
Human   218 P------------PPGPASAQP----LPAPEAAHTTGPTG-SAPNSPMALLTIGSSSEKEIDDVI 265

  Fly   430 NSIRISSTSS----------------SLQSTSAPISPSVSSVATS--VSEPDDIFDDILQNDSFN 476
            :.| ||..||                .|.|| .|:|.::..|.:|  |:.|           :..
Human   266 DEI-ISLESSYNDEMLSYLPGGTTGLQLPST-LPVSGNLLDVYSSQGVATP-----------AIT 317

  Fly   477 FDKNFNSEL-SIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDA 540
            ...:..:|| :||:|   :::.|..||.|:||||||||:|||||||||||||||||||:||.||.
Human   318 VSNSCPAELPNIKRE---ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDP 379

  Fly   541 FYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHG 605
                  ::|.|||||||:|||||:.|:.|..|.:..|.|||.:|..||.|..||:|||:||:.||
Human   380 ------EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHG 438

  Fly   606 ILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMED 670
                      |..|..|.|.|.: :.:||.|.:     |.:..|:    .:|..|.
Human   439 ----------LPVPPTPGLLSLA-TTSASDSLK-----PEQLDIE----EEGRPGA--------- 474

  Fly   671 CKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCGINCS 735
            ..:.|.||....:.|..    |.:|.|..|....|...:..:..:....|...:..::..|:
Human   475 ATFHVGGGPAQNAPHQQ----PPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGV--- 532

  Fly   736 TSCYIQHQLTSREGHPNHSHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLS---------SSHRS 791
                                      :..||..|    .|.|....|||||         ||.||
Human   533 --------------------------VGGLSGGA----LSPLRAASDPLLSSVSPAVSKASSRRS 567

  Fly   792 LGTVDED 798
            ..:::|:
Human   568 SFSMEEE 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	22/38 (58%)
		bHLHzip_MITF_like	504..577	CDD:381403	48/72 (67%)
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	41/174 (24%)
		bHLHzip_TFE3	337..427	CDD:381498	59/95 (62%)
		DUF3371	432..573	CDD:463372	41/206 (20%)