Protein Alignment Mitf and MITF

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 181/621 - (29%)
• Similarity: 254/621 - (40%)
• Gaps: 219/621 - (35%)

  Fly   164 PLSGGPTFKTATPTSRTQLKLQLQRE--QQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFID 226
            |.:..|...:::.|||..|:.||.||  |:|:...|||.|
Human    41 PGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKL------------------------- 80

  Fly   227 SGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVP--LQSIGVDVPPQVLQVSTVLENPTRY 289
                           |.:|.:|....:..:....:.||  |.| ...||.:||:|.|.|||||:|
Human    81 ---------------QAAQFMQQRVPVSQTPAINVSVPTTLPS-ATQVPMEVLKVQTHLENPTKY 129

  Fly   290 HVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDS 354
            |:.|.|:.||:||||.:              |||..|:    |..||.              |.:
Human   130 HIQQAQRQQVKQYLSTT--------------LANKHAN----QVLSLP--------------CPN 162

  Fly   355 AVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEP-TVLRPNSHGAGEPENAHRTAQLGLSKANSS 418
                   .|.|..||  |..||..      |..| .:|..||:  .|.|..::..:...:::...
Human   163 -------QPGDHVMP--PVPGSSA------PNSPMAMLTLNSN--CEKEGFYKFEEQNRAESECP 210

  Fly   419 LSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNS 483
            ..:|.|.:                               |..:.||:.|||:     :.:.::|.
Human   211 GMNTHSRA-------------------------------SCMQMDDVIDDII-----SLESSYNE 239

  Fly   484 E----------------------------------LSIKQE-PQNL-------------TDAEMN 500
            |                                  |:|... |.||             |::|..
Human   240 EILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEAR 304

  Fly   501 ALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKC 565
            ||||:||||||||:|||||||||||||||||||:||.:|.      |:|.|||||||:|||||:.
Human   305 ALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDP------DMRWNKGTILKASVDYIRK 363

  Fly   566 LKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLSAP--------TQP 622
            |:.|..|.::.|.||:::|..||.|:.||:||||||::||:.|..:  |.|.:|        .:|
Human   364 LQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPS--TGLCSPDLVNRIIKQEP 426

  Fly   623 YLKSFS---------LSPTASRSRRSLFDQPVEKKIQVIDGADGN--------MGMNQVDEFMED 670
            .|::.|         |:.|.:   ..|.|..:.....:..|.:.|        ||....|..|:|
Human   427 VLENCSQDLLQHHADLTCTTT---LDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDD 488

  Fly   671 CKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFE 706
            ....|...||:|||    .|...|.:|...:|.|.|
Human   489 TLSPVGVTDPLLSS----VSPGASKTSSRRSSMSME 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	21/38 (55%)
		bHLHzip_MITF_like	504..577	CDD:381403	48/72 (67%)
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		2/12 (17%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	61/227 (27%)
		Transactivation	224..295		12/75 (16%)
		bHLHzip_MITF	300..403	CDD:381496	67/108 (62%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		9/20 (45%)
		DUF3371	397..516	CDD:463372	32/127 (25%)
		DNA-binding regulation	401..431		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		11/29 (38%)