Protein Alignment Mitf and Tfe3

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_766060.2
• Gene: Tfe3 / 209446
• MGIID: 98511
• Length: 572
• Species: Mus musculus
• Alignment Length: 733
• Identity: 198/733 - (27%)
• Similarity: 281/733 - (38%)
• Gaps: 251/733 - (34%)

  Fly   118 LCMTNIRVSVGIDKDLEMILEMDP-SIVDLGD----------ISIDET-AEPRIVGLPPLSGGP- 169
            |.:.::....||..|:|:...:|| |..:|..          ||:..| ..|..:.....:||.
Mouse    38 LSLNSLLPESGIVADIELENILDPDSFYELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSR 102

  Fly   170 TFKTATPTSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACG 234
            |...::.:||..|:.||.|.|.|:...:::....|..|            ..|....|.:.|..|
Mouse   103 TPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAP------------FPSPAPASPAISVIG 155

  Fly   235 SGSSSLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQV 299
            .                   |:.|..|..|..:   .||.:||:|.|.||||||||:.|.::.||
Mouse   156 V-------------------SAGGHTLSRPPPA---QVPREVLKVQTHLENPTRYHLQQARRQQV 198

  Fly   300 RQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPS 364
            :||||.:..|          |||:.:
Mouse   199 KQYLSTTLGP----------KLASQA--------------------------------------- 214

  Fly   365 DDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSL-------SST 422
                 ::|            |..|:..:|    ...||.||.|...| |..||.:       ||.
Mouse   215 -----LTP------------PPGPSSAQP----LPAPETAHATGPTG-SAPNSPMALLTIGSSSE 257

  Fly   423 RSSSGIVNSIRISSTSS----------------SLQSTSAPISPSVSSVATS--VSEPDDIFDDI 469
            :....:::.| ||..||                .|.|| .|:|.::..|.:|  |:.|
Mouse   258 KEIDDVIDEI-ISLESSYNDEMLSYLPGGTAGLQLPST-LPVSGNLLDVYSSQGVATP------- 313

  Fly   470 LQNDSFNFDKNFNSEL-SIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTL 533
                :.....:..:|| :||:|   :::.|..||.|:||||||||:|||||||||||||||||||
Mouse   314 ----AITVSNSCPAELPNIKRE---ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTL 371

  Fly   534 LPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELE 598
            :||.:|.      ::|.|||||||:|||||:.|:.|..|.:..|.|||.:|..||.|..||:|||
Mouse   372 IPKSNDP------EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELE 430

  Fly   599 MQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQ 663
            :||:.||          |..|..|.|    ||.|.|....||  :|.:..|:
Mouse   431 LQAQIHG----------LPVPPNPGL----LSLTTSSVSDSL--KPEQLDIE------------- 466

  Fly   664 VDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDD 728
             :|......:.|.||.   :.::..|..|..||...|:
Mouse   467 -EEGRPSTTFHVSGGP---AQNAPPQQPPAPPSDALLD--------------------------- 500

  Fly   729 CCGINCSTSCYIQHQLTSREGHPNHSHHTGIREI----HSLSDSAQNSEFSRLEHCDDPLLS--- 786
                        .|..:...|......|.|:.:|    ..:.........|.|....|||||
Mouse   501 ------------LHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVS 553

  Fly   787 ------SSHRSLGTVDED 798
                  ||.||..:::|:
Mouse   554 PAVSKASSRRSSFSMEEE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	22/38 (58%)
		bHLHzip_MITF_like	504..577	CDD:381403	47/72 (65%)
Tfe3	NP_766060.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..152		16/76 (21%)
		MITF_TFEB_C_3_N	112..265	CDD:464952	57/257 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..248		15/98 (15%)
		Strong transcription activation domain. /evidence=ECO:0000255	259..270		2/11 (18%)
		bHLHzip_TFE3	336..426	CDD:381498	58/95 (61%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P19532	355..358		2/2 (100%)
		Leucine-zipper	408..429		10/20 (50%)
		DUF3371	431..570	CDD:463372	41/210 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..495		17/78 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..572		12/42 (29%)