DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mitf and Mitf

DIOPT Version :10

Sequence 1:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_001106669.1 Gene:Mitf / 17342 MGIID:104554 Length:526 Species:Mus musculus


Alignment Length:624 Identity:179/624 - (28%)
Similarity:250/624 - (40%) Gaps:225/624 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 TAEPRIVGLPPLSGGPTFKTATPTSRTQLKLQLQRE--QQQQMMIQQQTLDTAMDPKMHLLFGSG 216
            :||......||||      ::|.|||..|:.||.||  |:|:...|||.|               
Mouse    37 SAEHSGASKPPLS------SSTMTSRILLRQQLMREQMQEQERREQQQKL--------------- 80

  Fly   217 QGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVP--LQSIGVDVPPQVLQV 279
                                     |.:|.:|....:..:....:.||  |.| ...||.:||:|
Mouse    81 -------------------------QAAQFMQQRVAVSQTPAINVSVPTTLPS-ATQVPMEVLKV 119

  Fly   280 STVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPL 344
            .|.|||||:||:.|.|::||:||||.:              |||..||          :.:..| 
Mouse   120 QTHLENPTKYHIQQAQRHQVKQYLSTT--------------LANKHAS----------QVLSSP- 159

  Fly   345 ERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQ 409
                   |.:       .|.|.|||..|                                     
Mouse   160 -------CPN-------QPGDHAMPPVP------------------------------------- 173

  Fly   410 LGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVA-TSVSEPDDIFDDILQND 473
             |.|..||.::....:|   |..:.:......||.:....|.:::.: .|..:.||:.|||:   
Mouse   174 -GSSAPNSPMAMLTLNS---NCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDII--- 231

  Fly   474 SFNFDKNFNSE----------------------------------LSIKQE-PQNL--------- 494
              :.:.::|.|                                  |:|... |.||         
Mouse   232 --SLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTA 294

  Fly   495 ----TDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTI 555
                |::|..||||:||||||||:|||||||||||||||||||:||.:|.      |:|.|||||
Mouse   295 CIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDP------DMRWNKGTI 353

  Fly   556 LKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLSAP- 619
            ||:|||||:.|:.|..|.:..|.||:::|..||.|:.|::||||||::||:.|..:  |.|.:| 
Mouse   354 LKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPS--TGLCSPD 416

  Fly   620 -------TQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGA-------------------DGN 658
                   .:|.|::.|......::     |......:.:.||.                   ...
Mouse   417 LVNRIIKQEPVLENCSQELVQHQA-----DLTCTTTLDLTDGTITFTNNLGTMPESSPAYSIPRK 476

  Fly   659 MGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSS 697
            ||.|..|..|:|....|...||:|||.|...|...|..|
Mouse   477 MGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRS 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:464952 21/38 (55%)
bHLHzip_MITF_like 504..577 CDD:381403 48/72 (67%)
MitfNP_001106669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..54 6/16 (38%)
MITF_TFEB_C_3_N 56..194 CDD:464952 43/141 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..179 14/23 (61%)
Transactivation. /evidence=ECO:0000250 224..291 8/66 (12%)
bHLHzip_MITF 300..403 CDD:381496 37/151 (25%)
Leucine-zipper. /evidence=ECO:0000305|PubMed:23207919 374..395 14/33 (42%)
DUF3371 397..522 CDD:463372 62/132 (47%)
DNA-binding regulation. /evidence=ECO:0000250 401..431 19/29 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..526 6/37 (16%)

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