Protein Alignment Mitf and tfe3a

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_571923.2
• Gene: tfe3a / 114834
• ZFINID: ZDB-GENE-010919-2
• Length: 539
• Species: Danio rerio
• Alignment Length: 674
• Identity: 193/674 - (28%)
• Similarity: 278/674 - (41%)
• Gaps: 214/674 - (31%)

  Fly    87 GEEPPTTSF-----ADNIDKACPLPVLRSSDCDCVPLCMTNIRVSVGIDKDLEMILEMDPSIVDL 146
            |.|.|.|.:     |::::.....|:|..|                ||..|:|:     .|:
Zfish    23 GHERPQTVYVILDSAESVNLISVEPLLPES----------------GIVADIEV-----ESV--- 63

  Fly   147 GDISIDETAEPRIVGLPPLSGGPTFKTATP--------TSRTQLKLQLQREQ---QQQMMIQQQT 200
              .|.|..|...:.|.|....| :..:|.|        |||..::.:|.|:|   |::...|:|
Zfish    64 --FSADSDAFYELKGQPITPSG-SLTSADPVTPTGSVMTSRVLMRQELMRQQAQDQERREAQKQ- 124

  Fly   201 LDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPL 265
                                                :||.:|        .|.||:....:...|
Zfish   125 ------------------------------------ASSAQQ--------RLTDSTPAISVASNL 145

  Fly   266 QSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGN 330
            .:....||.:||:|.|.|||||:||:.|.|:.||:|||          |||...|:|:.:.:|..
Zfish   146 PAKPTQVPVEVLKVQTHLENPTKYHIQQAQRQQVKQYL----------SHTLGNKIASQTLATSP 200

  Fly   331 LQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISP-----FGGSFVRCDDINPIEPTV 390
            ....|                     ||..:.|:..:.|.||     .|.:....:|:  |:..:
Zfish   201 PPQPS---------------------SAPELAPAASSTPSSPLAVLSLGSNKEEIEDV--IDDII 242

  Fly   391 LRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSV 455
                     ..|::.....:.|..:...|.||...||  |.:.:.|:    |..:||      ::
Zfish   243 ---------SLESSLNDEFMTLIDSGLQLPSTLPVSG--NLLDVYSS----QGMAAP------TI 286

  Fly   456 ATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRR 520
            ..|.|.|.|     |||              :|:|   ::|||..|:.|:||||||||:||||||
Zfish   287 TVSNSCPAD-----LQN--------------VKRE---MSDAEAKAIMKERQKKDNHNLIERRRR 329

  Fly   521 FNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVEL 585
            ||.||||||||.|:||.||.      ::|.|||||||:|||||:.|:.|..|.::.|.||:::|.
Zfish   330 FNTNDRIKELGALIPKSSDP------ELRWNKGTILKASVDYIRKLQKEQQRSKEMETRQKKLEH 388

  Fly   586 QNRKLMSRIKELEMQAKSHG---------------ILLSENHLTSLS----APTQPYLKSFSLSP 631
            .||.||.||:||||||:.||               :.|..|..|.||    :.||....||...|
Zfish   389 ANRSLMLRIQELEMQARLHGLSSSQLSDSLTQTQTLTLEHNPNTDLSKTLLSITQTTPSSFLSPP 453

  Fly   632 TASRSRRSLFDQPVEKKIQVIDGAD------------GNMGMNQVDEFMED--CKYAVQGGDPML 682
            :::.|.......|:|.........|            .:||:.  |..|:|  ....|.|.||:|
Zfish   454 SSTSSVGGTVTSPLELGTLSFGELDDHTASVFSPALMADMGLG--DILMDDSGALSPVGGADPLL 516

  Fly   683 SSHSHMQSAPQSPSSKTLNSGSFE 706
            |:    .|...|.:|...:|.|.|
Zfish   517 SA----VSPGASKTSSRRSSFSME 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	20/38 (53%)
		bHLHzip_MITF_like	504..577	CDD:381403	46/72 (64%)
tfe3a	NP_571923.2	MITF_TFEB_C_3_N	101..239	CDD:464952	49/215 (23%)
		bHLHzip_MITF	305..408	CDD:381496	66/108 (61%)
		DUF3371	402..538	CDD:463372	36/141 (26%)