Protein Alignment Octbeta3R and GPR101

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_473362.1
• Gene: GPR101 / 83550
• HGNCID: 14963
• Length: 508
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 84/334 - (25%)
• Similarity: 135/334 - (40%)
• Gaps: 67/334 - (20%)

  Fly   136 LSLLLLKGFIFSSIIL----AAVLGNALVIISVQRNRKLRVITNYFVVSLAMADML-VALCA-MT 194
            :.:.|..|.|.|::::    |:.:||.::.:.:||..:|..:||.|:.:|.:.|:| ::|.| ..
Human    24 MPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWV 88

  Fly   195 FNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCF 259
            ...||.|.   |......|....||...|:.||:..:..:|||||.:|:.||.||..||.:....
Human    89 VATSVPLF---WPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYL 150

  Fly   260 MLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFV--VNKAYALISSSVSFWIPGIVML 322
            :|...||: |::..||...||.......|..     .||.:  .:.:|.::|......||.|||:
Human   151 LLYGTWIV-AILQSTPPLYGWGQAAFDERNA-----LCSMIWGASPSYTILSVVSFIVIPLIVMI 209

  Fly   323 VMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDC----DLNATSAREETHS 383
            ..|..:|..|.||...|    .|:..:|:.            :...||    |......:||..
Human   210 ACYSVVFCAARRQHALL----YNVKRHSLE------------VRVKDCVENEDEEGAEKKEEFQ- 257

  Fly   384 ALSNLEDMLQPATDEDDDRDECDELRVPSPPPRR---------------LSRSSIDLRDLEQERY 433
                         ||.:.|.: .|..|.:...|.               .|.||::.|..|:.|.
Human   258 -------------DESEFRRQ-HEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEARGSEEVRE 308

  Fly   434 EKVTHTDSA 442
            .....:|.:
Human   309 SSTVASDGS 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	62/203 (31%)
		TM helix 1	142..167	CDD:320194	7/28 (25%)
		TM helix 2	174..200	CDD:320194	9/27 (33%)
		TM helix 3	213..243	CDD:320194	11/29 (38%)
		TM helix 4	255..278	CDD:320194	6/22 (27%)
		TM helix 5	302..331	CDD:320194	9/28 (32%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
GPR101	NP_473362.1	7tmA_GPR101	33..465	CDD:320343	82/325 (25%)
		TM helix 1	33..59	CDD:320343	6/25 (24%)
		TM helix 2	66..91	CDD:320343	8/24 (33%)
		TM helix 3	104..134	CDD:320343	11/29 (38%)
		TM helix 4	146..168	CDD:320343	6/22 (27%)
		TM helix 5	189..218	CDD:320343	9/28 (32%)
		2A1904	<243..>357	CDD:273344	16/90 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..338		16/89 (18%)
		TM helix 6	392..422	CDD:320343
		TM helix 7	433..458	CDD:320343
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..508