Protein Alignment Octbeta3R and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 1301
• Identity: 280/1301 - (21%)
• Similarity: 430/1301 - (33%)
• Gaps: 503/1301 - (38%)

  Fly     1 MSGVNVADLLATTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAAAKTTTTPTSSL 65
            :||.....|...|:.:.:...||..              ::|...||::|.......|..|..:
Mosquito    37 LSGTATVTLAGATVGVGVRGLAGGL--------------VRPPAYTGYVSYMKQFNFTGNPIDN- 86

  Fly    66 PITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPN-ITA-----NGSDIAVD 124
                             .|.::|.                    :||: |.|     :||.:|:.
Mosquito    87 -----------------RTGAEAG--------------------LGPDRIDADDDEDDGSSLALH 114

  Fly   125 NQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVA 189
            |.      |..|:::|:.|         ...||.||.:::...|:|:.:||||::|||:.|::||
Mosquito   115 NY------WALLAIILVFG---------TAAGNILVCLAIVWERRLQNVTNYFLMSLAITDLMVA 164

  Fly   190 LCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTH 254
            |..|.... :.|..|.:......|.|:..|||.|.||||:|||.||||||.::..|:::..|.|.
Mosquito   165 LSVMPLGI-LTLVKGHFPLDSEYCLVWICLDVLFCTASIMHLCTISVDRYLSLRYPMKFGRNKTR 228

  Fly   255 KTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGI 319
            :.|...::.||:|...:|. |:.|.:  ::.|   .|:..|....:.:..|.|:.|.|.|:||..
Mosquito   229 RRVVLKISFVWLLSIAMSL-PLSLMY--SKNH---ASVLVDGTCQIPDPVYKLVGSIVCFYIPLC 287

  Fly   320 VMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPT-----------SLSYLHPSDCDLN 373
            |||:.|....:...:|.:.|....|....:|..:|  |.|.           .||.  |:..:.:
Mosquito   288 VMLITYTLTVRLLAQQSENLGGVGSGGGWSSGWLG--QAPAFDRRNTWKRIIKLSL--PAAQNPH 348

  Fly   374 ATSAREETHSALSNLEDMLQPATDEDDDRDECD----ELRVPSPPPRRLSRSSIDLRDLEQERYE 434
            |.|| ..|.:.||.|              |..|    |..:|.|       |||
Mosquito   349 AHSA-ASTDTELSTL--------------DNHDLWLLESSIPEP-------SSI----------- 380

  Fly   435 KVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTS 499
                     :|.|:|:              |..::.   |:....|...:||..|..|      :
Mosquito   381 ---------TMTAMQR--------------FGEEML---KLSQGLESVAQHSDRNSGQ------N 413

  Fly   500 GSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIIS 564
            ||..| |||            |.|.|.                           |:::
Mosquito   414 GSSRS-PEP------------SREKES---------------------------FRKK------- 431

  Fly   565 GPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLL 629
             |...|:|....|                        :.|:       ..|||
Mosquito   432 -PANAKHAPTPVT------------------------MVTV-------RSPVP------------ 452

  Fly   630 SKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTP 694
            ||.:||||..:.   .|..:.:.......|.|.:.|.|:.                      ..|
Mosquito   453 SKKRRSSTSTWI---ARRNSGTPPPVRLVRKRFKSLPHAL----------------------PPP 492

  Fly   695 NKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPAT 759
            ...||.:|             :||...|    ..||:...:|          ....|.|.:
Mosquito   493 ASDDIEVD-------------EQFMQDV----LYELRDREDR----------GSVHGSSAR---- 526

  Fly   760 PPPSLSPPELPEPSGL--LIASSSELAEIFRSLSFPLGRPAGA----PQRLSTLSDQVCANYLMS 818
                      |..:||  :.|::|......|.     ||.||:    |::         |:.|.:
Mosquito   527 ----------PGAAGLDGVPAAASRATSDRRE-----GRDAGSNPAGPRQ---------AHPLAA 567

  Fly   819 PPNTPA----PPAISVPNGGAMDSSASSNAQSASINVYFLS----PPPHAAAPGYTPSDT---ST 872
            |..|.|    ||....|..|..........:.|.|.:...|    |...||:.|    |:   ||
Mosquito   568 PSQTAATLKLPPPCKCPFFGEGAPGRQQYLRPAEIKIVKTSTDFGPMGGAASNG----DSLVYST 628

  Fly   873 VSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAG 937
            :|:                   :|.||::.:|...:.|:||.:....     :.||  .||.||
Mosquito   629 ISI-------------------SSGSNVTTQPTRSISSSLSTLPASA-----LASP--SRKGSA- 666

  Fly   938 DADVSV------------SGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTY--DVNV 988
            ...:||            |..|||           |.|:|.      |..|...|.|:.  .:|:
Mosquito   667 PKGISVVTWDQRRHQRRGSSFGGA-----------RTSLLL------TPTKASPSSVSLRRSINL 714

  Fly   989 INFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRR-----GGICIFVDEEEAEIIEQRPRGIT 1048
            .:.:.|..........|......|..:.|:...|::.     ||
Mosquito   715 RHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQTGGGGG--------------------- 758

  Fly  1049 FAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSS 1113
                          |..:....||.....|.|.|.||:.|..||                    :
Mosquito   759 --------------GGAVGGGNGTAVAMMAVAAASSTVPTLATT--------------------T 789

  Fly  1114 SSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFL 1178
            .:.|..|.|.:::.     |:|..|.           |..:|      .|.||.:.||::...|:
Mosquito   790 MAVRSHHSRNSSMI-----SRNSSRH-----------GRIIR------LEQKATKVLGVVFFTFV 832

  Fly  1179 LCWLPFFLWYVITSLCGPACPCPDVLVVVLF----WIGYFNSTLNPLIYAYFNRDFREAFRNTLE 1239
            :.|.|||:..::.|:|.   .|.|.:...:|    |:||.:|.:||:.|..||:.||:|||..|.
Mosquito   833 ILWAPFFVLNLLPSVCK---HCEDNIDQWVFEFVTWLGYASSLVNPIFYTIFNKAFRDAFRKVLL 894

  Fly  1240 C 1240
            |
Mosquito   895 C 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	65/195 (33%)
		TM helix 1	142..167	CDD:320194	5/24 (21%)
		TM helix 2	174..200	CDD:320194	12/25 (48%)
		TM helix 3	213..243	CDD:320194	19/29 (66%)
		TM helix 4	255..278	CDD:320194	6/22 (27%)
		TM helix 5	302..331	CDD:320194	11/28 (39%)
		7tm_GPCRs	<1161..1234	CDD:475119	26/76 (34%)
		TM helix 6	1167..1189	CDD:410628	7/21 (33%)
		TM helix 7	1202..1227	CDD:410628	9/28 (32%)
5-HT2B	XP_061501050.1	None