Protein Alignment Octbeta3R and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: XP_003436280.1
• Gene: Octbeta2R / 1273081
• VectorBaseID: AGAMI1_002356
• Length: 526
• Species: Anopheles gambiae
• Alignment Length: 1249
• Identity: 269/1249 - (21%)
• Similarity: 332/1249 - (26%)
• Gaps: 817/1249 - (65%)

  Fly    26 TSQAAATSATNASHLQPA--------------TLTGHI--------STTAAAKTTTTPTSSLPIT 68
            |:....:|::::||||.|              .|..|.        :..||:..:...|..|
Mosquito     9 TTNYMVSSSSSSSHLQSAAALLASTFGLADGTVLYNHSVRDRGDAGALAAASAASVAGTGGL--- 70

  Fly    69 SQFVDASLTSLSLTATSSDASYSS----PFSSYLSSDSTFELLSTVGPN-------ITANGSDIA 122
                 .|.|:...|.:..|||.||    .|||......|.|   |||.|       |.|.|.:
Mosquito    71 -----ESATAGGDTLSVFDASGSSIMLQGFSSTAPIGGTIE---TVGANESIVDGGIDAGGGE-- 125

  Fly   123 VDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADML 187
                      |:|:.||:||..|...||:||:.||.||||||:|:||||||||||||||||||::
Mosquito   126 ----------WIDVVLLVLKASIMMFIIVAAIFGNLLVIISVKRHRKLRVITNYFVVSLAMADIM 180

  Fly   188 VALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNM 252
            ||:.|||||.||::: |.|.||.|||:|:|||||||||||||||||||||||||||:||:||::|
Mosquito   181 VAMMAMTFNFSVQIT-GSWKFGSFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISM 244

  Fly   253 THKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIP 317
            |.:.|..||.|.||.|||:||.|||.||||||:|.:|:..:||.|.|:|||.||:||||:||:||
Mosquito   245 TKRVVAIMLLNTWISPALLSFVPIFAGWYTTEKHKQEVLDNPDSCLFIVNKPYAVISSSISFFIP 309

  Fly   318 GIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETH 382
            ..:|:..|::||:||.||.|
Mosquito   310 CTIMVFTYFQIFREANRQEK--------------------------------------------- 329

  Fly   383 SALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMA 447
                                                                             
Mosquito   330 ----------------------------------------------------------------- 329

  Fly   448 LQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTA 512
                                                          ||:|..|:.
Mosquito   330 ----------------------------------------------QLALRQGTA---------- 338

  Fly   513 YRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGPGGGKYAALSET 577
                                                  .|..:..|||    |.|||
Mosquito   339 --------------------------------------MLMHQHNTGG----GVGGG-------- 353

  Fly   578 DFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKTKRSSTECFTL 642
                                                                             
Mosquito   354 ----------------------------------------------------------------- 353

  Fly   643 EKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTPNKPDILLDINVLS 707
                                        |.|||
Mosquito   354 ----------------------------GSGGG-------------------------------- 358

  Fly   708 EQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEP 772
                                                                             
Mosquito   359 ----------------------------------------------------------------- 358

  Fly   773 SGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMD 837
                                                                      .||.|:.
Mosquito   359 ----------------------------------------------------------TNGEALS 365

  Fly   838 SSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISP 902
            .|.||                            .|::|
Mosquito   366 GSGSS----------------------------KTLTL--------------------------- 375

  Fly   903 KPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVGGVGGRQGRCSILAG 967
                                                                             
Mosquito   376 ----------------------------------------------------------------- 375

  Fly   968 YDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFV 1032
                                                          ||
Mosquito   376 ----------------------------------------------HE----------------- 377

  Fly  1033 DEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKRS 1097
                                                                 :|.
Mosquito   378 -----------------------------------------------------VDA--------- 380

  Fly  1098 IHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKA 1162
              ||||                             :|:| ...|                  .|.
Mosquito   381 --EQTP-----------------------------TKDR-HLIK------------------MKR 395

  Fly  1163 EHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGYFNSTLNPLIYAYFN 1227
            |||||||||||||.|:||||||||||:||||| ..||.||::|.::|||||||||||||||||||
Mosquito   396 EHKAARTLGIIMGTFILCWLPFFLWYIITSLC-DRCPNPDIVVALVFWIGYFNSTLNPLIYAYFN 459

  Fly  1228 RDFREAFRNTLECV 1241
            |||||||||||:|:
Mosquito   460 RDFREAFRNTLDCM 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	130/195 (67%)
		TM helix 1	142..167	CDD:320194	14/24 (58%)
		TM helix 2	174..200	CDD:320194	20/25 (80%)
		TM helix 3	213..243	CDD:320194	27/29 (93%)
		TM helix 4	255..278	CDD:320194	13/22 (59%)
		TM helix 5	302..331	CDD:320194	16/28 (57%)
		7tm_GPCRs	<1161..1234	CDD:475119	59/72 (82%)
		TM helix 6	1167..1189	CDD:410628	19/21 (90%)
		TM helix 7	1202..1227	CDD:410628	19/24 (79%)
Octbeta2R	XP_003436280.1	7tmA_DmOct-betaAR-like	134..466	CDD:320194	225/1092 (21%)
		TM helix 1	134..160	CDD:320194	15/25 (60%)
		TM helix 2	167..193	CDD:320194	20/25 (80%)
		TM helix 3	205..235	CDD:320194	27/29 (93%)
		TM helix 4	247..270	CDD:320194	13/22 (59%)
		TM helix 5	294..323	CDD:320194	16/28 (57%)
		TM helix 6	394..424	CDD:320194	25/29 (86%)
		TM helix 7	434..459	CDD:320194	19/24 (79%)