Protein Alignment Octbeta3R and LOC1273080

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: XP_061498027.1
• Gene: LOC1273080 / 1273080
• VectorBaseID: AGAMI1_014239
• Length: 1236
• Species: Anopheles gambiae
• Alignment Length: 1462
• Identity: 505/1462 - (34%)
• Similarity: 661/1462 - (45%)
• Gaps: 445/1462 - (30%)

  Fly    12 TTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAAAKTTTTPTSSLPITSQFVDASL 76
            |:.::|.||.........|||        ||.||.|.::|.|:|..:..            .|:|
Mosquito     3 TSRSVPPTAQPEVNALLGAAT--------QPITLPGALATVASALASAG------------SATL 47

  Fly    77 TSLSLTATSSDASYSSPFSSYL-SSDSTFELL---STVGPNITANGSDIAVDNQAELEE---SWL 134
            |||::..||...........:. :.|:|....   ..|||.  .|..::.|...:.:.|   ..:
Mosquito    48 TSLAMAPTSGGPEVDGAAGGWNGTGDATSGAAGDHQPVGPG--TNAVNLTVPTASTIVEPADRLV 110

  Fly   135 DLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASV 199
            :|::|.||..||.|||:.||||||||||||.:|||||||||||||||||||||||||||||||||
Mosquito   111 ELTVLCLKSLIFGSIIIGAVLGNALVIISVHKNRKLRVITNYFVVSLAMADMLVALCAMTFNASV 175

  Fly   200 ELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANV 264
            ||| |:|:||.|||:|:|||||||||||||||||||||||:||||||||||.||.:||.||||||
Mosquito   176 ELS-GRWLFGSFMCDVWNSLDVYFSTASILHLCCISVDRYFAIVRPLEYPLYMTQRTVFFMLANV 239

  Fly   265 WILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIF 329
            |:|||||||||||||||||.|||..:.::||.|.|||||:||:||||:|||||||||:.||:||:
Mosquito   240 WVLPALISFTPIFLGWYTTAEHLAALKINPDLCIFVVNKSYAIISSSISFWIPGIVMVTMYYRIY 304

  Fly   330 KEAIRQRKALSRTSSNILLNSV---------HMGHTQQPTSLSYLH-------PSDCDL--NATS 376
            |||:||||||||||||||||||         |..|........:||       .|||||  :...
Mosquito   305 KEAVRQRKALSRTSSNILLNSVQINNASNTLHANHHHHNHHHQHLHHRNHHLRASDCDLGIDIKD 369

  Fly   377 AREETHSALSNLEDMLQ----PATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVT 437
            .:.:|||.||:|:  ||    |....:.|    |:..|||.||||||||||||||||.:...|:.
Mosquito   370 IQHDTHSELSDLD--LQVPIVPTVVANTD----DDFLVPSSPPRRLSRSSIDLRDLEYKGEGKIK 428

  Fly   438 HTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKEL---DKEHSHPNGPQQQLSLTS 499
            .:||..|:..|..:    |.|:          ::..:.|..||.   .::...||..||:.:...
Mosquito   429 ASDSVSSIFPLHYE----NNLR----------YSGSEPIHIKEAQQQQQQQQQPNDQQQRRASRK 479

  Fly   500 GSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIIS 564
            .|              |..:|..:           |....|..||       .|.|...||   :
Mosquito   480 DS--------------FRQINFFQ-----------PFFSRNSLLK-------TYIKGGAGG---A 509

  Fly   565 GPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKG------- 622
            |.|||.....|.|      .||......|.|.:.      ::.:|::.........:.
Mosquito   510 GGGGGGGGGGSGT------VGAVTGSASAIAGNQ------LNNNRSVERNNKNNDNRSNNNILDL 562

  Fly   623 FNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFF-----RRSRNRKLSHSYNGCGGGKERK--- 679
            .|:.|.|:|...|..|..|  .||||..:..|.|.     :|.:..|.::|...|  .|:.|
Mosquito   563 INVASSLNKGGDSEKEMNT--HKRHQIAASESDFLTMIEKQRQKLGKNTNSLKNC--NKDEKELM 623

  Fly   680 -----------LERRQRQHSDTDSTPNK--------PDILLDINVL--------SEQSGAS-VIQ 716
                       |:::|:|.........|        .|.:..| ||        ||..||| ...
Mosquito   624 YALSDSDFSVGLQKQQQQDEGVARRCFKNLVGSEVARDGIFKI-VLNGEGNGGASETGGASPAAV 687

  Fly   717 QFSDGV-----QLIDFSELKTPPERIRSDDELAQLADCF--GESPQQPATPPPSLSPPELPEPSG 774
            ..:.||     .:|....:.||.          .|..||  |.:..:||...|::.  ||....|
Mosquito   688 GLAGGVDGGTESVIGSGTMGTPD----------ILIGCFDHGFTGSRPALNSPTVK--ELVADEG 740

  Fly   775 LLIASSS------------------ELAEIFRSLSFPLGR--------PAGAPQRLSTLSDQVCA 813
            .||.:||                  ::.::..:::.|.|.        |||...:|||
Mosquito   741 ALIKASSLKVTDRGDGTSEPTAEGAKVIDLISTINGPAGEDGVRSVKPPAGPDNQLST------- 798

  Fly   814 NYLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVV 878
                         |::|          |.||:.:.:|:..              |:.||:|||:|
Mosquito   799 -------------ALNV----------SLNARCSPVNIQL--------------SEASTISLDLV 826

  Fly   879 TSLP---MPVPVPQPNPQMASQSNISPK--------PEIILD-----STLSPVEGCGDEHR--DV 925
            .:.|   :| .||...|...:..:|:.:        |:|::|     :|:||........|  .:
Mosquito   827 ATSPKEKLP-KVPTSAPATVTTIDIASEMMMMLADNPDIVIDNSHTGATVSPTSRTVTPSRAPSI 890

  Fly   926 TSPLFKRKDSAGDADVSVSGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVIN 990
            .:|..:.....|                                     ||||:|.|||::||||
Mosquito   891 MTPSPQHHPRLG-------------------------------------RKRQSSTVTYNINVIN 918

  Fly   991 F-SQENSDSRSYIPM-------GRVSTSSAKHEFSNKSSL--IRRGGICIFVDEEEAEIIEQRPR 1045
            | :.:|.|..:...:       |..:|:..:...|..||.  .|||.|||.::.:..
Mosquito   919 FQAGDNPDDDASFQLNNRNGNGGGTATAGGRSNSSTSSSQKHQRRGAICIVINNDNV-------- 975

  Fly  1046 GITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKR---------SIHEQ 1101
                                      ..||.|.|   |...|....|::::         ..|:|
Mosquito   976 --------------------------VHANDTDT---DLEEDGCCATAAQQHRNYQHQHDHQHQQ 1011

  Fly  1102 TPDLGQRP---------------------ASSSSSTRFWHKRTAAVTACWQQSKNRKRR------ 1139
            ......:|                     .|.::|.|  |.:...:...|...|....|
Mosquito  1012 QQQQQHQPQQRYANQPGCCYGGGGRHQDDGSGAASCR--HHKFRKIKCLWNHLKRYGLRRSGPSV 1074

  Fly  1140 -----------------------------------FKTGCSH-------CGATGGSVRPAKGWKA 1162
                                               ...||.|       ||..|.|.||:|||:|
Mosquito  1075 QVSSCGGACDFGPPSPTVSTGAGGAGGNRLAVPSPVPPGCRHSRCSSVGCGEGGTSTRPSKGWRA 1139

  Fly  1163 EHKAARTLGIIMGVFLLCWLPFFLWYVITSLCG-PACPCPDVLVVVLFWIGYFNSTLNPLIYAYF 1226
            |||||||||||||||||||||||||||||:||| .|||||||::.||||||||||||||||||||
Mosquito  1140 EHKAARTLGIIMGVFLLCWLPFFLWYVITTLCGEEACPCPDVVITVLFWIGYFNSTLNPLIYAYF 1204

  Fly  1227 NRDFREAFRNTLECVLPCLEKRNPY--NAYYV 1256
            ||||||||||||:.:|||..:|:||  :.|||
Mosquito  1205 NRDFREAFRNTLQSLLPCFVRRSPYGHSVYYV 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	159/195 (82%)
		TM helix 1	142..167	CDD:320194	18/24 (75%)
		TM helix 2	174..200	CDD:320194	25/25 (100%)
		TM helix 3	213..243	CDD:320194	26/29 (90%)
		TM helix 4	255..278	CDD:320194	19/22 (86%)
		TM helix 5	302..331	CDD:320194	21/28 (75%)
		7tm_GPCRs	<1161..1234	CDD:475119	66/73 (90%)
		TM helix 6	1167..1189	CDD:410628	21/21 (100%)
		TM helix 7	1202..1227	CDD:410628	21/24 (88%)
LOC1273080	XP_061498027.1	None