Protein Alignment ltl and cDIP

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_650951.1
• Gene: cDIP / 42512
• FlyBaseID: FBgn0038865
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 100/405 - (24%)
• Similarity: 160/405 - (39%)
• Gaps: 101/405 - (24%)

  Fly   138 LDIGRCKIRAVQQEDFR-GIQRVTNLILVSNII----TRLDRGSFPKSLLILHLGRNQLESLNGS 197
            ||:..|.||.:..|:|. |..::..|:|..|.|    |:..||:
  Fly   121 LDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGA--------------------- 164

  Fly   198 LHDLHNLESLFINANNITSLD----DELPDGGQLRLLMAHNNRLERLPANM-AGMHSLETVHIHC 257
                .|||.:|:|.|.:..|.    |.|.   :|:.|....||||.|.|:: ||:.||..|.:..
  Fly   165 ----GNLEFIFLNRNKLGKLQAGAFDNLL---KLQYLDLTENRLEALAADVFAGLKSLRHVGLAG 222

  Fly   258 NQLRSFDR-VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLK 321
            |||.:.:. :..:..:|..|...||.|..:.:..|.|..:...:|    ::...|:..|.:| |.
  Fly   223 NQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQ----YVDLSNNPELVVL-LL 282

  Fly   322 NANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRL-LPDPRGVQELMLVNLDLDNNRIDSLNGA 385
            |.|.:.......|:..::...|:..:.||.||::.| .|....::.|:     |.||.:..| .:
  Fly   283 NINATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALEHLV-----LRNNSLVQL-AS 341

  Fly   386 LAGLGNLRILNLAGN----------RLEHLQV------GDFD-------GMIRLDILDLTGNQLA 427
            |:.:..||.|::|.|          |..||::      |..:       ||..|..||::||.|.
  Fly   342 LSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLT 406

  Fly   428 ELKPLEMTLLPSLKILKVAYNN----------------------ITKLEQDFKG---LPVLCQAN 467
            |:.|.....|..|....:..||                      :...:.||.|   ..:.|...
  Fly   407 EIDPSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIACMYR 471

  Fly   468 LTNNQ--ISTISSEL 480
            |...:  .|:.|||:
  Fly   472 LPEKEGVDSSSSSEI 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	97/399 (24%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380	8/20 (40%)
		leucine-rich repeat	159..180	CDD:275380	7/24 (29%)
		leucine-rich repeat	181..203	CDD:275380	0/21 (0%)
		leucine-rich repeat	204..226	CDD:275380	8/25 (32%)
		leucine-rich repeat	227..249	CDD:275380	10/22 (45%)
		leucine-rich repeat	250..272	CDD:275380	5/22 (23%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..315	CDD:275380	2/17 (12%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	6/22 (27%)
		leucine-rich repeat	367..391	CDD:275380	6/23 (26%)
		leucine-rich repeat	392..415	CDD:275380	11/45 (24%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..462	CDD:275380	6/46 (13%)
		leucine-rich repeat	463..483	CDD:275380	6/20 (30%)
cDIP	NP_650951.1	LRR	107..>410	CDD:443914	86/327 (26%)
		leucine-rich repeat	118..142	CDD:275380	8/20 (40%)
		leucine-rich repeat	143..166	CDD:275380	7/47 (15%)
		leucine-rich repeat	167..190	CDD:275380	8/25 (32%)
		leucine-rich repeat	191..214	CDD:275380	10/22 (45%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		leucine-rich repeat	239..265	CDD:275380	7/25 (28%)
		leucine-rich repeat	266..325	CDD:275380	15/63 (24%)
		leucine-rich repeat	326..347	CDD:275380	6/26 (23%)
		leucine-rich repeat	348..394	CDD:275380	11/45 (24%)
		leucine-rich repeat	395..418	CDD:275380	9/22 (41%)