Protein Alignment CG7546 and BAG6

DIOPT Version :9

• Sequence 1: NP_001137904.1
• Gene: CG7546 / 38844
• FlyBaseID: FBgn0035793
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_016866764.1
• Gene: BAG6 / 7917
• HGNCID: 13919
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 1486
• Identity: 331/1486 - (22%)
• Similarity: 509/1486 - (34%)
• Gaps: 481/1486 - (32%)

  Fly     3 INLKVKTLDARIHEFSIDNELTIRQFKDQIAEKTNIAAENQRIIYQGRVLVDDKQVKEYDVDGKV 67
            :.:.|||||::...|.:..::.:::||:.||...:|.:|.||:|||||||.|||:::||:|.|||
Human    17 LEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKV 81

  Fly    68 LHVAERPPFSQRGANARNNDEPMRTFRNVARPPPPGMRTSPYFRALDGMLVGTMAIPVNNGPVAG 132
            :|:.||.|                                |......|...||.:....:|   |
Human    82 IHLVERAP--------------------------------PQTHLPSGASSGTGSASATHG---G 111

  Fly   133 TRPPPNRYPNSSSFCINRITVALHMIDCADNIAAYLENPAVGLNNQSLDILQRGRWSMESTVVEV 197
            ..||..|.|.:|          :|    ..|..:|:   .||..|...|          .:.|:|
Human   112 GSPPGTRGPGAS----------VH----DRNANSYV---MVGTFNLPSD----------GSAVDV 149

  Fly   198 GVSSTDLPRNNN-------IIDMVQDAVTAALSHTGARNYTVVQ------LPTVYTNENGETSQQ 249
            .::....|..:.       ...|::| :...||....|.....|      .|...|.|....|.|
Human   150 HINMEQAPIQSEPRVRLVMAQHMIRD-IQTLLSRMECRGGPQPQHSQPPPQPPAVTPEPVALSSQ 213

  Fly   250 RTAEAITSEGAASGAASNASGETTAATVIIEDVIETDD-EVADGASDRSVTPTPEPEAEGAVGGQ 313
             |:|.:.||...                  .:.:|.:: |....|.:..:||.|.|
Human   214 -TSEPVESEAPP------------------REPMEAEEVEERAPAQNPELTPGPAP--------- 250

  Fly   314 QVTAAETPTSSVGSANDAAAEGGNNSGPRRRTRPQVLAQVIQHYRGVQARLAPFVDRYYEILQND 378
               |..||.....:.|..:              |....:|:|..:.:::||.||:.||||:|...
Human   251 ---AGPTPAPETNAPNHPS--------------PAEYVEVLQELQRLESRLQPFLQRYYEVLGAA 298

  Fly   379 PTFE-ESDTDGRENAQRIFDRVSEAFHYLSHAQHAISDLMLDLSQPGPRVL-TCRPILVEQSGYI 441
            .|.: .::.:|||..||:.:.|.|:...|.:...|:|||..:|:...||.| ..||:
Human   299 ATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACTPPRHLHVVRPM-------- 355

  Fly   442 RSNNIFTPNFLAPPSGIINEPFRNRAPGSASAAGTQTATTAGTQTPTSAGTPTAVAPSQAANLQA 506
              ::..||..|...:          .|...:...|.|.|..||:.|.   ||.|.||.....
Human   356 --SHYTTPMVLQQAA----------IPIQINVGTTVTMTGNGTRPPP---TPNAEAPPPGPG--- 402

  Fly   507 ATDASRSAAAMAEIASRAAGAAAEMAAGAASAAAGAANAAAAAARDLSSDQVEDPIDEPMVGPNA 571
              .||..|.:...:.|.|.||.      ....|...|.:.....| :|...||..:   |:..|.
Human   403 --QASSVAPSSTNVESSAEGAP------PPGPAPPPATSHPRVIR-ISHQSVEPVV---MMHMNI 455

  Fly   572 AGAETLAQEQQRLEMDHDHDQAQSETPERETRP--VPRLRVYVP-----------------VTLP 617
            .|..:|                 |..|:..|:|  ||.    .|                 :.||
Human   456 QGPLSL-----------------SPCPDSGTQPGGVPS----APTGPLGPPGHGQTLGSTLIQLP 499

  Fly   618 --PPNPQLEMARII--QAMV------------------NGQR-------PNDIHVEFNAPNVMSI 653
              ||.....:|..|  ||||                  .||:       |..:.:....|....
Human   500 SLPPEFMHAVAHQITHQAMVAAVASAAAALFGLSLLPPTGQQVPGFPTAPTRVVIARPTPPQAR- 563

  Fly   654 NLPVH-----VMTTVRQAPAAGSNETADQSAS-------------ESSSPESAPASGNGESPNAA 700
              |.|     |..|: |....|:|.:..|..|             ...:|..||.    .:|..|
Human   564 --PSHPGGPPVSGTL-QGAGLGTNASLAQMVSGLVGQLLMQPVLVAQGTPGMAPP----PAPATA 621

  Fly   701 STSSGTRSGDQRANTLPTTATQTRSTSRPQI------QIGGN--------NNWGGRIAPTHTAFD 751
            |.|:||.:....|...|....|...|.:|.:      |:.||        ....|..:||.|.
Human   622 SASAGTTNTATTAGPAPGGPAQPPPTPQPSMADLQFSQLLGNLLGPAGPGAGGSGVASPTITV-- 684

  Fly   752 RFLPCNSHHIREPEQLLQNNSTSRSTSTAPAGGATVVPPTSAAVTRPVTTGRIQRGSNTIRPMWS 816
             .:|.....::.....||      :|.|||       ||.......|
Human   685 -AMPGVPAFLQGMTDFLQ------ATQTAP-------PPPPPPPPPP------------------ 717

  Fly   817 SRRQRPASEQLSNLGPAAWAQAQTQTTHIPSAHVGAGSTNGAGVGAGRVRPVGGSTINRDRLATR 881
                 ||.||.:...|.:           ||.  ||||..|.|:.:  :.|...:::.:..|::.
Human   718 -----PAPEQQTMPPPGS-----------PSG--GAGSPGGLGLES--LSPEFFTSVVQGVLSSL 762

  Fly   882 TAHVG----------------GGSTNGGLP--SGRRGRLQAATSRLSRHLPTQLANFLINNMRNN 928
            ...:|                .||:|...|  .|..|...|..|.|.:       ||
Human   763 LGSLGARAGSSESIAAFIQRLSGSSNIFEPGADGALGFFGALLSLLCQ-------NF-------- 812

  Fly   929 APTASVGSAVAAVGDTAASPSGEAAPIASTTPAAPLQTVLPTSTPTPRGDSNNLRSQLRTFLNDS 993
                       ::.|......|...|:                        ..|:.|||:|.:..
Human   813 -----------SMVDVVMLLHGHFQPL------------------------QRLQPQLRSFFHQH 842

  Fly   994 LFVGVPINEQTIPGAIGRALDWFGESLVYLPQYERPEYN--SRDSVCNILRVSLRLIIELCNGAP 1056
            ...|    ::..|..|..|....   :..|.:|.|..::  ......:|:|.:|..:.|..|...
Human   843 YLGG----QEPTPSNIRMATHTL---ITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIA 900

  Fly  1057 AGV----DSAQFEQSLKQICDQFRKRLYSVLFL---CLGSANAELYWRQLMRLLCAPMRSNFRNE 1114
            |.|    ||. |...|.::|:|   .|:..|.|   |||....|         |.|.:....|.
Human   901 AHVLHCTDSG-FGARLLELCNQ---GLFECLALNLHCLGGQQME---------LAAVINGRIRR- 951

  Fly  1115 ALQFLCIYIDPTIPAQTDTVDAQQFLVLRSIQAAPPTAADEPF-----VAPPPFAFNPQQQQLQE 1174
                :...::|::.:...|:   ..|.|:.:....|...|...     |..||       |.|.|
Human   952 ----MSRGVNPSLVSWLTTM---MGLRLQVVLEHMPVGPDAILRYVRRVGDPP-------QPLPE 1002

  Fly  1175 QTLDTD-VEMSEVTASGSNSSPA----------------------DELPAVIVGSEPWHMSFPND 1216
            :.::.. .|.:.......|:|||                      ||.......:|||..:.|.:
Human  1003 EPMEVQGAERASPEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASAETEPWAAAVPPE 1067

  Fly  1217 WLPVITRDLQTQAEQSNRPQPPFSDAYISGMSAKRRKIIQSEKPTASVECLIANGVQRAIQSVGL 1281
            |:|:|.:|:|:|  :..:||||.||||:|||.|||||.:|.|.|    :.|::..|.||.::.|.
Human  1068 WVPIIQQDIQSQ--RKVKPQPPLSDAYLSGMPAKRRKTMQGEGP----QLLLSEAVSRAAKAAGA 1126

  Fly  1282 GGSNGGSALNASISMDTVIGSIAHDSTIQAAYTDAVRNSLKERTERDVDFKTSKYP 1337
            .......:|:..:....|          |.:|...:|:.:::|.:.|.::...::|
Human  1127 RPLTSPESLSRDLEAPEV----------QESYRQQLRSDIQKRLQEDPNYSPQRFP 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7546	NP_001137904.1	UBQ	3..73	CDD:214563	31/69 (45%)
		Scythe_N	3..73	CDD:176404	31/69 (45%)
		DUF3538	350..466	CDD:288877	33/117 (28%)
BAG6	XP_016866764.1	Scythe_N	17..87	CDD:176404	31/69 (45%)
		DUF3538	270..386	CDD:314866	37/135 (27%)
		DNA_pol3_gamma3	<955..1146	CDD:331207	55/216 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157547
Domainoid	1	1.000	76	1.000	Domainoid score	I9006
eggNOG	1	0.900	-	-		E1_KOG4248
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50086
OrthoDB	1	1.010	-	-		D1233552at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto89948
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15204
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4967
SonicParanoid	1	1.000	-	-		X4047
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.990