Protein Alignment CG7546 and BAG6

DIOPT Version :10

• Sequence 1: NP_001137904.1
• Gene: CG7546 / 38844
• FlyBaseID: FBgn0035793
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001374941.1
• Gene: BAG6 / 7917
• HGNCID: 13919
• Length: 1171
• Species: Homo sapiens
• Alignment Length: 1474
• Identity: 329/1474 - (22%)
• Similarity: 508/1474 - (34%)
• Gaps: 468/1474 - (31%)

  Fly     3 INLKVKTLDARIHEFSIDNELTIRQFKDQIAEKTNIAAENQRIIYQGRVLVDDKQVKEYDVDGKV 67
            :.:.|||||::...|.:..::.:::||:.||...:|.:|.||:|||||||.|||:::||:|.|||
Human    17 LEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKV 81

  Fly    68 LHVAERPPFSQRGANARNNDEPMRTFRNVARPPPPGMRTSPYFRALDGMLVGTMAIPVNNGPVAG 132
            :|:.||.|                                |......|...||.:....:|   |
Human    82 IHLVERAP--------------------------------PQTHLPSGASSGTGSASATHG---G 111

  Fly   133 TRPPPNRYPNSSSFCINRITVALHMIDCADNIAAYLENPAVGLNNQSLDILQRGRWSMESTVVEV 197
            ..||..|.|.:|          :|    ..|..:|:   .||..|...|          .:.|:|
Human   112 GSPPGTRGPGAS----------VH----DRNANSYV---MVGTFNLPSD----------GSAVDV 149

  Fly   198 GVSSTDLPRNNN-------IIDMVQDAVTAALSHTGARNYTVVQ------LPTVYTNENGETSQQ 249
            .::....|..:.       ...|::| :...||....|.....|      .|...|.|....|.|
Human   150 HINMEQAPIQSEPRVRLVMAQHMIRD-IQTLLSRMECRGGPQPQHSQPPPQPPAVTPEPVALSSQ 213

  Fly   250 RTAEAITSEGAASGAASNASGETTAATVIIEDVIETDD-EVADGASDRSVTPTPEPEAEGAVGGQ 313
             |:|.:.||...                  .:.:|.:: |....|.:..:||.|.|
Human   214 -TSEPVESEAPP------------------REPMEAEEVEERAPAQNPELTPGPAP--------- 250

  Fly   314 QVTAAETPTSSVGSANDAAAEGGNNSGPRRRTRPQVLAQVIQHYRGVQARLAPFVDRYYEILQND 378
               |..||.....:.|..:              |....:|:|..:.:::||.||:.||||:|...
Human   251 ---AGPTPAPETNAPNHPS--------------PAEYVEVLQELQRLESRLQPFLQRYYEVLGAA 298

  Fly   379 PTFE-ESDTDGRENAQRIFDRVSEAFHYLSHAQHAISDLMLDLSQPGPRVL-TCRPILVEQSGYI 441
            .|.: .::.:|||..||:.:.|.|:...|.:...|:|||..:|:...||.| ..||:
Human   299 ATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACTPPRHLHVVRPM-------- 355

  Fly   442 RSNNIFTPNFLAPPSGIINEPFRNRAPGSASAAGTQTATTAGTQTPTSAGTPTAVAPSQAANLQA 506
              ::..||..|...:          .|...:...|.|.|..||:.|.   ||.|.||.....
Human   356 --SHYTTPMVLQQAA----------IPIQINVGTTVTMTGNGTRPPP---TPNAEAPPPGPG--- 402

  Fly   507 ATDASRSAAAMAEIASRAAGAAAEMAAGAASAAAGAANAAAAAARDLSSDQVEDPIDEPMVGPNA 571
              .||..|.:...:.|.|.||.      ....|...|.:.....| :|...||..:   |:..|.
Human   403 --QASSVAPSSTNVESSAEGAP------PPGPAPPPATSHPRVIR-ISHQSVEPVV---MMHMNI 455

  Fly   572 AGAETLAQEQQRLEMDHDHDQAQSETPERETRP--VP-----------------RLRVYVPVTLP 617
            .|..:|                 |..|:..|:|  ||                 ...:.:| :||
Human   456 QGPLSL-----------------SPCPDSGTQPGGVPSAPTGPLGPPGHGQTLGSTLIQLP-SLP 502

  Fly   618 PP---------NPQLEMARIIQAMVNGQRPNDIHVEF-NAPNVMSINLPV-------H-----VM 660
            |.         ..|..:|.:..|....|.|.     | .||..:.|..|.       |     |.
Human   503 PEFMHAVAHQITHQAMVAAVASAAAGQQVPG-----FPTAPTRVVIARPTPPQARPSHPGGPPVS 562

  Fly   661 TTVRQAPAAGSNETADQSAS-------------ESSSPESAPASGNGESPNAASTSSGTRSGDQR 712
            .|: |....|:|.:..|..|             ...:|..||.    .:|..||.|:||.:....
Human   563 GTL-QGAGLGTNASLAQMVSGLVGQLLMQPVLVAQGTPGMAPP----PAPATASASAGTTNTATT 622

  Fly   713 ANTLPTTATQTRSTSRPQI------QIGGN--------NNWGGRIAPTHTAFDRFLPCNSHHIRE 763
            |...|....|...|.:|.:      |:.||        ....|..:||.|.   .:|.....::.
Human   623 AGPAPGGPAQPPPTPQPSMADLQFSQLLGNLLGPAGPGAGGSGVASPTITV---AMPGVPAFLQG 684

  Fly   764 PEQLLQNNSTSRSTSTAPAGGATVVPPTSAAVTRPVTTGRIQRGSNTIRPMWSSRRQRPASEQLS 828
            ....||      :|.|||       ||.......|                       ||.||.:
Human   685 MTDFLQ------ATQTAP-------PPPPPPPPPP-----------------------PAPEQQT 713

  Fly   829 NLGPAAWAQAQTQTTHIPSAHVGAGSTNGAGVGAGRVRPVGGSTINRDRLATRTAHVG------- 886
            ...|.:           ||.  ||||..|.|:.:  :.|...:::.:..|::....:|
Human   714 MPPPGS-----------PSG--GAGSPGGLGLES--LSPEFFTSVVQGVLSSLLGSLGARAGSSE 763

  Fly   887 ---------GGSTNGGLP--SGRRGRLQAATSRLSRHLPTQLANFLINNMRNNAPTASVGSAVAA 940
                     .||:|...|  .|..|...|..|.|.:       ||                   :
Human   764 SIAAFIQRLSGSSNIFEPGADGALGFFGALLSLLCQ-------NF-------------------S 802

  Fly   941 VGDTAASPSGEAAPIASTTPAAPLQTVLPTSTPTPRGDSNNLRSQLRTFLNDSLFVGVPINEQTI 1005
            :.|......|...|:                        ..|:.|||:|.:.....|    ::..
Human   803 MVDVVMLLHGHFQPL------------------------QRLQPQLRSFFHQHYLGG----QEPT 839

  Fly  1006 PGAIGRALDWFGESLVYLPQYERPEYN--SRDSVCNILRVSLRLIIELCNGAPAGV----DSAQF 1064
            |..|..|....   :..|.:|.|..::  ......:|:|.:|..:.|..|...|.|    ||. |
Human   840 PSNIRMATHTL---ITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHVLHCTDSG-F 900

  Fly  1065 EQSLKQICDQFRKRLYSVLFL---CLGSANAELYWRQLMRLLCAPMRSNFRNEALQFLCIYIDPT 1126
            ...|.::|:|   .|:..|.|   |||....|         |.|.:....|.     :...::|:
Human   901 GARLLELCNQ---GLFECLALNLHCLGGQQME---------LAAVINGRIRR-----MSRGVNPS 948

  Fly  1127 IPAQTDTVDAQQFLVLRSIQAAPPTAADEPF-----VAPPPFAFNPQQQQLQEQTLDTD-VEMSE 1185
            :.:...|:   ..|.|:.:....|...|...     |..||       |.|.|:.::.. .|.:.
Human   949 LVSWLTTM---MGLRLQVVLEHMPVGPDAILRYVRRVGDPP-------QPLPEEPMEVQGAERAS 1003

  Fly  1186 VTASGSNSSPA----------------------DELPAVIVGSEPWHMSFPNDWLPVITRDLQTQ 1228
            ......|:|||                      ||.......:|||..:.|.:|:|:|.:|:|:|
Human  1004 PEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASAETEPWAAAVPPEWVPIIQQDIQSQ 1068

  Fly  1229 AEQSNRPQPPFSDAYISGMSAKRRKIIQSEKPTASVECLIANGVQRAIQSVGLGGSNGGSALNAS 1293
              :..:||||.||||:|||.|||||.:|.|.|    :.|::..|.||.::.|........:|:..
Human  1069 --RKVKPQPPLSDAYLSGMPAKRRKTMQGEGP----QLLLSEAVSRAAKAAGARPLTSPESLSRD 1127

  Fly  1294 ISMDTVIGSIAHDSTIQAAYTDAVRNSLKERTERDVDFKTSKYP 1337
            :....|          |.:|...:|:.:::|.:.|.::...::|
Human  1128 LEAPEV----------QESYRQQLRSDIQKRLQEDPNYSPQRFP 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7546	NP_001137904.1	Ubl_BAG6	3..73	CDD:340507	31/69 (45%)
		BAG6	350..457	CDD:463449	33/108 (31%)
BAG6	NP_001374941.1	Ubl_BAG6	17..87	CDD:340507	31/69 (45%)
		BAG6	270..386	CDD:463449	37/135 (27%)
		PHA03247	<374..577	CDD:223021	54/244 (22%)
		PRK07764	<944..1135	CDD:236090	55/216 (25%)