Protein Alignment CG8560 and CPA2

DIOPT Version :10

• Sequence 1: NP_648120.3
• Gene: CG8560 / 38830
• FlyBaseID: FBgn0035781
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001860.2
• Gene: CPA2 / 1358
• HGNCID: 2297
• Length: 419
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 158/428 - (36%)
• Similarity: 232/428 - (54%)
• Gaps: 30/428 - (7%)

  Fly     6 AVVLLLASVAL-----AVENYDGYKIYDINARNAFEKQLLLRLSGNE--AYDFFDLPRSLDASSR 63
            |:.|:|...||     .:|.:.|.::.:|...|..:.:.||:|...|  ..||:..|.:...::.
Human     2 AMRLILFFGALFGHIYCLETFVGDQVLEIVPSNEEQIKNLLQLEAQEHLQLDFWKSPTTPGETAH 66

  Fly    64 VMVKPEDQEGFEHLLEKYGVNYSVINENFGESLRQERDENQNQRLMNLRSAERS--VSFKAFHRH 126
            |.|...:.:..:..||..|:.||::.|:....|.:|.:|    .|.| |..|||  .:|.|:|..
Human    67 VRVPFVNVQAVKVFLESQGIAYSIMIEDVQVLLDKENEE----MLFN-RRRERSGNFNFGAYHTL 126

  Fly   127 AEINAYLDELAAAYPSRVSVQVAGKSYENRDIKTITI-TNGDGKTGKNVVFLDAGIHAREWIAHA 190
            .||:..:|.|.|.:|..||....|.|:|||.:..:.. |.||    |..::||||||||||:..|
Human   127 EEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGD----KPAIWLDAGIHAREWVTQA 187

  Fly   191 GALYVIHQLVENFAAN---SELLKDFDWVILPVVNPDGYEYSHTTTRMWRKTRKPIS-SACYGTD 251
            .||:..:::|.::..:   :.:|...|..:|||.|||||.:|.|..|||||||..:| |.|.|.|
Human   188 TALWTANKIVSDYGKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMWRKTRSKVSGSLCVGVD 252

  Fly   252 ANRNFDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLSLTGRGKFYLTLHSYGNYLLYPW 316
            .|||:|..:|..||||..|||::.|.:|.||.|.:.|.|.:.| .|:.|.::|||||...|::|:
Human   253 PNRNWDAGFGGPGASSNPCSDSYHGPSANSEVEVKSIVDFIKS-HGKVKAFITLHSYSQLLMFPY 316

  Fly   317 GWTSALPSSWRDNDEVAQGGADAIKSATGTKYTVGSSTNVLYAAAGGSDD--YAFGVANFPVSIT 379
            |:.......:.:..||||..|.:::|..||||.||...:|:|.|:|||.|  |.:|:   ..|..
Human   317 GYKCTKLDDFDELSEVAQKAAQSLRSLHGTKYKVGPICSVIYQASGGSIDWSYDYGI---KYSFA 378

  Fly   380 MEL-PAGGTGFNPSTSQIEGFVSETWVGIKAMAQKVAD 416
            .|| ..|..||.....||.....|||:|:||:.:.|.|
Human   379 FELRDTGRYGFLLPARQILPTAEETWLGLKAIMEHVRD 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_648120.3	Propep_M14	27..99	CDD:460505	18/73 (25%)
		M14_CP_A-B_like	123..414	CDD:349433	121/298 (41%)
CPA2	NP_001860.2	Propep_M14	28..102	CDD:460505	18/73 (25%)
		M14_CPA	118..417	CDD:349442	125/307 (41%)