Protein Alignment smid and SAP1

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_010966.1
• Gene: SAP1 / 856771
• SGDID: S000000849
• Length: 897
• Species: Saccharomyces cerevisiae
• Alignment Length: 991
• Identity: 219/991 - (22%)
• Similarity: 373/991 - (37%)
• Gaps: 239/991 - (24%)

  Fly    30 LDVKQMTRELMQKYPEYSRRKFGPFRQLVHQAFSIISESYNLDKVSSSEEDCVSEDSEPPPTNSV 94
            |:.|:..:|.:|.:...:....  |:|.:.:.....::||..|:||
Yeast    44 LEEKKRYKEALQGWKALTTDVL--FKQTLIEHNYPNTQSYTKDEVS------------------- 87

  Fly    95 MNNMMNSLYSQPRKPLAPKPISEPIDISSGDENE-DDSNTKTTNGDGVAAAAAPPPPTPAVQGSA 158
            :.|.:..||.:....|  |.:.:.:.......|: ..|.|.|.:......:..|||....|.|
Yeast    88 LQNGIRELYHKSVMHL--KRVKKLVREEPAPRNDMPSSKTYTNHSSSFTRSTEPPPVFQMVPG-- 148

  Fly   159 LKRLMEEVPEIAVAAKKVA--KPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRNVPGL 221
              |:|:.:........|.|  .|:.....:|.:|::     |..|:|:..:.||.
Yeast   149 --RMMKTLRNRNACGYKTAYSNPSLSSYGNSTSIKR-----GEDAENIRVNFVPS---------- 196

  Fly   222 YQQLHQNQSRDRLRKFKRDLEVQHP-----TESFRDIGGMDSTLKELCE-MLIHIKSPEFYFQLG 280
             :.|..|.|    |:.|..:|...|     ||.:.|        |.:.| :||.:.:.|....:|
Yeast   197 -KPLSNNAS----RQHKNPIEHNDPPLKKETELYSD--------KYISEPILIDLTNDEDDHDVG 248

  Fly   281 LLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPC 345
            :|....:.                                      :.||.....||.:..|
Yeast   249 ILKGHNVF--------------------------------------DEEESDGFEFDVSDYY--- 272

  Fly   346 VLFIDEIDAIGGNRQWASKDMERRI-----VSQLISSLDNLKANEFGQSV-------------VV 392
                |....:....:...|:..|||     :.|.:|.|....:....:||             :.
Yeast   273 ----DNFSEVDVEEEEEEKEERRRIKTLEAIQQQMSDLSVTSSTSSNKSVSSSENVPGSCIQSLP 333

  Fly   393 IAATTRPDVLDPGLRRIGRFDHEIA-----IHIPSRKERREILRIQCEGLSVDPKLNYDKIAELT 452
            ..|...|.:..|.|..:.|.....|     :...:..:..:|...|...|..:..:.|.|..:.|
Yeast   334 TTAPALPSLPPPPLLNVDRASSTGALKPHSLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKST 398

  Fly   453 PGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEE 517
            |..:.......::|:.|      :.|...:.:|:|..:..|                ||:|..::
Yeast   399 PTLITKSTPTFITRSKS------NTKPIIKSNASSPTSSLT----------------VPNSVIQK 441

  Fly   518 TAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKA--TNGNSSIKSPQKTPKKSAEKPTDAAMD 580
            ....|.|.::|...|:.::       :|.:.|.||:  ...:.:.|.|..:.||::..|   :..
Yeast   442 PKTAAMAAKRVLNSKKVAS-------NPALNTTKKSHPILKSKTAKVPNSSSKKTSSHP---SRP 496

  Fly   581 VDNVAP--------EEPKK-------------AVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEE 624
            |.|..|        ::|.|             ..::::.|....|...|......|:..:...|.
Yeast   497 VSNSKPYSHGASQNKKPSKNQTTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEP 561

  Fly   625 FADPNFCLTLI--DFVDAIKVMQPSAKREGFITV----PDTTWDDIGALEKIREELKLAVLAPVK 683
            ..|......::  :.:|:::.:...|.::.|..:    .:..||||..||..:..||.||:.|..
Yeast   562 EIDKKVLREILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFL 626

  Fly   684 YPEMLERLGLTAP-SGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRAC 747
            .|::..  ||..| .|:||.||||.|||:||:|:|.|:...|.|:....|.:.|:||||:.|||.
Yeast   627 RPDLFR--GLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRAL 689

  Fly   748 FQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLL--------------------TEM 792
            |..|:..:|.:||.||.||:...|::..: |.|..||.|:.|                    ::.
Yeast   690 FAIAKKLSPSIIFVDEIDSIMGSRNNENE-NESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDT 753

  Fly   793 DGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDV 857
            :|.|:...|.:|||||.|..||.|..|  |.....|:..||...|....|....:.|..:  .:.
Yeast   754 NGDEDDTRVLVLAATNLPWSIDEAARR--RFVRRQYIPLPEDQTRHVQFKKLLSHQKHTL--TES 814

  Fly   858 DLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQH----------FQEALQ 912
            |.||:...||||:|:|:..|.|.|:|..||        :|.|..:.::.          |:.:|.
Yeast   815 DFDELVKITEGYSGSDITSLAKDAAMGPLR--------DLGDKLLETEREMIRPIGLVDFKNSLV 871

  Fly   913 QLRPSVNEQDRKIYDK 928
            .::|||::.....|:|
Yeast   872 YIKPSVSQDGLVKYEK 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	8/40 (20%)
		CDC48	<242..933	CDD:273521	177/776 (23%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904	37/221 (17%)
		McrB	<539..>659	CDD:441011	36/121 (30%)
		RecA-like_VPS4-like	607..788	CDD:410917	68/185 (37%)
		AAA_lid_3	815..850	CDD:465537	17/42 (40%)
		Vps4_C	<847..893	CDD:462762	8/41 (20%)