Protein Alignment smid and RIX7

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_013066.1
• Gene: RIX7 / 850625
• SGDID: S000003957
• Length: 837
• Species: Saccharomyces cerevisiae
• Alignment Length: 969
• Identity: 334/969 - (34%)
• Similarity: 491/969 - (50%)
• Gaps: 251/969 - (25%)

  Fly     4 AKPLLHDHLITI---------RVKK-YLEEHIGETYLDVKQMTRELMQKYPEYSRRKFGPFRQLV 58
            ||.|....:.|.         |||| .|::.|.....||.:...|....||.|:..:
Yeast    65 AKDLTAGEIFTFCLTKDLSLQRVKKVVLQKTIDRMLKDVIESELEEFGSYPGYNNEE-------- 121

  Fly    59 HQAFSIISESYNLDKVSSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISS 123
                   .|..:|::..:.:...:..|     ||. ||..:.|.:|:                 |
Yeast   122 -------EEKPSLEEELAKKNMMIERD-----TNE-MNKRITSTWSK-----------------S 156

  Fly   124 GDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSE 188
            |..:|  |.|:|.:           |.|            |||.:    :||.:|..|..|
Yeast   157 GSVSE--SITETDD-----------PKT------------EEVKK----SKKRSKEGTCKV---- 188

  Fly   189 AIQKLHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDI 253
                       :.:.:.||..|                                   |..|.:.:
Yeast   189 -----------KRQKIKEDRSP-----------------------------------PNSSLKSL 207

  Fly   254 GGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPA 317
            ||||..:.:|.|:: :.|..||.:...|:.|.||:|||||||||||.:|.|::|:|::|.:.|.|
Yeast   208 GGMDDVVAQLMELIGLPILHPEIFLSTGVEPPRGVLLHGPPGCGKTSIANALAGELQVPFISISA 272

  Fly   318 TELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQ-WASKDMERRIVSQLISSLDNL 381
            ..::.|:|||||::||::||:|...:||::|.||||||...|. .|.::||||||:||::|:|.|
Yeast   273 PSVVSGMSGESEKKIRDLFDEARSLAPCLVFFDEIDAITPKRDGGAQREMERRIVAQLLTSMDEL 337

  Fly   382 ---KANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKL 443
               |.|  |:.|::|.||.|||.||..|||.||||.||.:::|:...|..||:...:.|.:|..:
Yeast   338 TMEKTN--GKPVIIIGATNRPDSLDAALRRAGRFDREICLNVPNEVSRLHILKKMSDNLKIDGAI 400

  Fly   444 NYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGET 508
            ::.|:|:||||:|||||.|||:.|.:.|:||     ..:.:|..:...||.|    :.|||
Yeast   401 DFAKLAKLTPGFVGADLKALVTAAGTCAIKR-----IFQTYANIKSTPTTAT----DSSED---- 452

  Fly   509 PVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEK 573
                                                 |:|..:.|....||:|
Yeast   453 -------------------------------------NMEIDETANGDESSLK------------ 468

  Fly   574 PTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLI--- 635
                  :..|:....|...|:|                     |:.|.||..:.....|..|
Yeast   469 ------NTANMIDPLPLSVVQQ---------------------FIRNYPEPLSGEQLSLLSIKYE 506

  Fly   636 DFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVL 700
            ||:.|:..:||:||||||.||||.||.::|||:::|.||.:|::.|:|.||:.|::|::||.|||
Yeast   507 DFLKALPTIQPTAKREGFATVPDVTWANVGALQRVRLELNMAIVQPIKRPELYEKVGISAPGGVL 571

  Fly   701 LCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFD 765
            |.|||||||||||||:|||:..||||:|||||:|.|||||||::|..|.|||.|.||||||||.|
Yeast   572 LWGPPGCGKTLLAKAVANESRANFISIKGPELLNKYVGESERSIRQVFTRARASVPCVIFFDELD 636

  Fly   766 SLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVG 830
            :|.|:|..  ..:.|.:|:||.||||:||:.:|:|::::.||||||:||||:|||||||..|::.
Yeast   637 ALVPRRDT--SLSESSSRVVNTLLTELDGLNDRRGIFVIGATNRPDMIDPAMLRPGRLDKSLFIE 699

  Fly   831 FPEQSERTEILKATTKNGKRPVLADDVDLDEIA--AQTEGYTGADLAGLVKQASMFSLRQSL--- 890
            .|...|:.:|:|..||:...| |:.|||.:||.  .:...::|||||.||:::|:.:|::..
Yeast   700 LPNTEEKLDIIKTLTKSHGTP-LSSDVDFEEIIRNEKCNNFSGADLAALVRESSVLALKRKFFQS 763

  Fly   891 --------NNGDTNLDDL---------CVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
                    |:.|...:||         .|....|:.||::::|||:::||..||:|..|
Yeast   764 EEIQSVLDNDLDKEFEDLSVGVSGEEIIVTMSDFRSALRKIKPSVSDKDRLKYDRLNKK 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	17/76 (22%)
		CDC48	<242..933	CDD:273521	290/721 (40%)
RIX7	NP_013066.1	CDC48	<192..824	CDD:273521	293/760 (39%)